Results 171 to 180 of about 11,135 (204)

Interplay between efferocytosis and atherosclerosis

Archives of Cardiovascular Diseases, 2023
In an adult human, billions of cells die and turn over daily. During this process, many apoptotic cells are produced and subsequently cleared by phagocytes - a process termed efferocytosis, which plays a critical role in tissue homeostasis. Efferocytosis is an important mechanism in the control of inflammatory processes.
Luc, Rochette, Geoffrey, Dogon, Eve, Rigal, Marianne, Zeller, Yves, Cottin, Catherine, Vergely   +5 more
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Modulation of Macrophage Efferocytosis in Inflammation [PDF]

Frontiers in Immunology, 2011
A critical function of macrophages within the inflammatory milieu is the removal of dying cells by a specialized phagocytic process called efferocytosis ("to carry to the grave"). Through specific receptor engagement and induction of downstream signaling, efferocytosing macrophages promote resolution of inflammation by (i) efficiently engulfing dying ...
Peter Henson, Donna L Bratton, Bratton Donna L   +2 more
exaly   +4 more sources

Efferocytosis in atherosclerosis

Nature Reviews Cardiology
Cardiovascular disease is the leading cause of death worldwide, and it commonly results from atherosclerotic plaque progression. One of the increasingly recognized drivers of atherosclerosis is dysfunctional efferocytosis, a homeostatic mechanism responsible for the clearance of dead cells and the resolution of inflammation.
Shaunak S. Adkar, Nicholas J. Leeper
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Efferocytosis and Bone Dynamics

Current Osteoporosis Reports
This review summarizes the recently published scientific evidence regarding the role of efferocytosis in bone dynamics and skeletal health.Several types of efferocytes have been identified within the skeleton, with macrophages being the most extensively studied. Efferocytosis is not merely a 'clean-up' process vital for maintaining skeletal homeostasis;
Batoon, Lena, Hawse, John R., McCauley, Laurie K., Weivoda, Megan M., Roca, Hernan   +4 more
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Effect of diabetes on efferocytosis process

Molecular Biology Reports, 2022
Diabetes is a complex of genetic, metabolic, and autoimmune disorders that are characterized by hyperglycemia. Elevated apoptotic cell count following defective clearance of dead cells that can cause chronic inflammation is a hallmark of the diabetic wound. Effective dead cell clearance is a prerequisite for rapid inflammation resolution and successful
Ali Mahmoudi, Ali Ahmadizad firouzjaei, Fatemeh darijani, Jamshid Gholizadeh Navashenaq, Eskandar Taghizadeh, Majid Darroudi, Seyed Mohammad Gheibihayat   +6 more
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Methods for Quantitative Efferocytosis Assays

2023
Efferocytosis, the phagocytic removal of apoptotic cells, is a dynamic process requiring recruitment of numerous regulatory proteins to mediate the uptake, engulfment, and degradation of apoptotic cells. Herein, we describe microscopy-based methods for the enumeration of efferocytic events and characterization of the spatiotemporal dynamics of ...
Nima, Taefehshokr, Bryan, Heit
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Macrophage efferocytosis in health and disease

Cell Biochemistry and Function, 2023
AbstractCreating cellular homeostasis within a defined tissue typically relates to the processes of apoptosis and efferocytosis. A great example here is cell debris that must be removed to prevent unwanted inflammatory responses and then reduce autoimmunity.
Shokufeh Razi, Javad Yaghmoorian Khojini, Fateme Kargarijam, Susan Panahi, Zahra Tahershamsi, Amir Tajbakhsh, Seyed Mohammad Gheibihayat   +6 more
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Quantitative Efferocytosis Assays

2016
Efferocytosis, the phagocytic removal of apoptotic cells, is a dynamic process requiring recruitment of numerous regulatory proteins to forming efferosomes in a tightly regulated manner. Herein we describe microscopy-based methods for the enumeration of efferocytic events and characterization of the spatiotemporal dynamics of signaling molecule ...
Amanda L, Evans, Jack W D, Blackburn, Charles, Yin, Bryan, Heit   +3 more
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Efferocytosis in Homeostasis

Apoptotic cells are removed by professional and nonprofessional phagocytes via the process of "efferocytosis." Efferocytosis is highly efficient such that accumulation of dead cells is rarely seen in healthy tissues, even though our bodies remove 200-400 billion apoptotic cells daily.
Christian, Maueröder, Caitlin M, Gillis, Kodi S, Ravichandran   +2 more
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Mechanism of efferocytosis in atherosclerosis

Journal of Molecular Medicine
Atherosclerosis (AS) is a chronic inflammatory vascular disease that occurs in the intima of large and medium-sized arteries with the immune system's involvement. It is a common pathological basis for high morbidity and mortality of cardiovascular diseases.
Li-Xia Shu, Liu-li Cao, Xin Guo, Zong-Bao Wang, Shu-Zhi Wang   +4 more
openaire   +2 more sources