Results 201 to 210 of about 16,803 (230)

Macrophage efferocytosis in health and disease

Cell Biochemistry and Function, 2023
AbstractCreating cellular homeostasis within a defined tissue typically relates to the processes of apoptosis and efferocytosis. A great example here is cell debris that must be removed to prevent unwanted inflammatory responses and then reduce autoimmunity.
Shokufeh Razi, Javad Yaghmoorian Khojini, Fateme Kargarijam, Susan Panahi, Zahra Tahershamsi, Amir Tajbakhsh, Seyed Mohammad Gheibihayat   +6 more
openaire   +2 more sources

Pirate bacteria hijack efferocytosis

Nature Reviews Microbiology, 2014
exaly   +2 more sources

The Tim gene family in efferocytosis

Genes & Genomics, 2020
One of the key features of the plasma membrane is the asymmetrical distribution of phospholipids across it. Especially, phosphatidylserine (PS) exclusively locates on its inner leaflet. Thus, the exposure of PS on the surface of cells could function as a signal initiating various cellular processes such as phagocytosis of apoptotic cells called ...
Deokhwan Kim, Sang-Ah Lee, Hyunji Moon, Kwanhyeong Kim, Daeho Park   +4 more
openaire   +2 more sources

Mechanism of efferocytosis in atherosclerosis

Journal of Molecular Medicine
Atherosclerosis (AS) is a chronic inflammatory vascular disease that occurs in the intima of large and medium-sized arteries with the immune system's involvement. It is a common pathological basis for high morbidity and mortality of cardiovascular diseases.
Li-Xia Shu, Liu-li Cao, Xin Guo, Zong-Bao Wang, Shu-Zhi Wang   +4 more
openaire   +2 more sources

Efferocytosis: molecular mechanisms and pathophysiological perspectives

Immunology & Cell Biology, 2018
AbstractDuring the life of a human being, several tons of apoptotic cells and debris are produced. These apoptotic particles should be cleared quickly and accurately from the body, as they may lose their membrane integrity with the probability of leakage of cytotoxic materials and other intracellular antigens into the environment.
Seyed Mohammad, Gheibi Hayat, Vanessa, Bianconi, Matteo, Pirro, Amirhossein, Sahebkar   +3 more
openaire   +2 more sources

Efferocytosis in inflammatory bone disorders

Trends in Pharmacological Sciences
Efferocytosis, the clearance of apoptotic cells (ACs) by phagocytes, is crucial for bone homeostasis and immune balance. This tightly regulated process depends on molecular markers such as phosphatidylserine on ACs and MERTK on phagocytes. In the bone microenvironment, multiple cell types participate in efferocytosis, including osteal macrophages ...
Linlin, Wen, Rongrong, Ye, Wenhao, Zhai, Daowei, Li, Hongchen, Sun   +4 more
openaire   +2 more sources

Dual-Fluorescence In Vitro Efferocytosis Assay

2022
The clearance of dead cells by macrophages, termed "efferocytosis," drives the resolution of inflammation, restricts necrosis, and restores homeostasis. Defects in efferocytosis contribute to many diseases, particularly atherosclerosis. Multiple methods to test efferocytosis by macrophages in vitro exist, but each has distinct disadvantages.
openaire   +2 more sources

TAMing efferocytosis to fight tumors

Science Translational Medicine, 2020
Preventing clearance of dying tumor cells elicits an inflammatory response by macrophages, supporting development of antitumor immunity in mice.
openaire   +1 more source

Drugging the efferocytosis process: concepts and opportunities

Nature Reviews Drug Discovery, 2022
Kodi S Ravichandran
exaly  

Efferocytosis induces macrophage proliferation to help resolve tissue injury

Cell Metabolism, 2021
Brennan D Gerlach, Patrick Baah Ampomah, Arif Yurdagul   +2 more
exaly