Results 91 to 100 of about 5,135,675 (370)

Therapeutic Potential of Cinnamon Oil: Chemical Composition, Pharmacological Actions, and Applications

Pharmaceuticals
Cinnamon oil, an essential oil extracted from plants of the genus Cinnamomum, has been highly valued in ancient Chinese texts for its medicinal properties. This review summarizes the chemical composition, pharmacological actions, and various applications
Jiageng Guo, Xinya Jiang, Yu Tian, Shidu Yan, Jiaojiao Liu, Jinling Xie, Fan Zhang, Chun Yao, Erwei Hao   +8 more
doaj   +1 more source

Combination of Morroniside and Diosgenin Prevents High Glucose-Induced Cardiomyocytes Apoptosis

Molecules, 2017
Cornus officinalis and Dioscorea opposita are two traditional Chinese medicines widely used in China for treating diabetes mellitus and its complications, such as diabetic cardiomyopathy.
Wen-Xia Pi, Xiao-Peng Feng, Li-Hong Ye, Bao-Chang Cai   +3 more
doaj   +1 more source

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source

Beneficial Effects of Naringenin in Cigarette Smoke-Induced Damage to the Lung Based on Bioinformatic Prediction and In Vitro Analysis

Molecules, 2020
Naringenin is found mainly in citrus fruits, and is thought to be beneficial in the prevention and control of lung diseases. This study aims to investigate the mechanisms of naringenin against the damage in the lung caused by cigarette smoke.
Pan Chen, Ziting Xiao, Hao Wu, Yonggang Wang, Weiyang Fan, Weiwei Su, Peibo Li   +6 more
doaj   +1 more source

Dupilumab Efficacy and Safety in Moderate‐to‐Severe Uncontrolled Asthma

New England Journal of Medicine, 2018
BACKGROUND Dupilumab is a fully human anti–interleukin‐4 receptor α monoclonal antibody that blocks both interleukin‐4 and interleukin‐13 signaling. We assessed its efficacy and safety in patients with uncontrolled asthma.
M. Castro, J. Corren, I. Pavord, J. Maspero, S. Wenzel, K. Rabe, W. Busse, L. Ford, L. Sher, M. Fitzgerald, C. Katelaris, Y. Tohda, Bingzhi Zhang, H. Staudinger, G. Pirozzi, N. Amin, M. Ruddy, B. Akinlade, A. Khan, J. Chao, R. Martincova, N. Graham, J. Hamilton, B. Swanson, N. Stahl, G. Yancopoulos, A. Teper   +26 more
semanticscholar   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Protective Effects of Nintedanib against Polyhexamethylene Guanidine Phosphate-Induced Lung Fibrosis in Mice

Molecules, 2018
Nintedanib (NDN), a tyrosine kinase inhibitor, has been shown to have anti-tumor, anti-inflammatory, and anti-fibrotic effects in several reports. We investigated the protective effects of NDN against polyhexamethylene guanidine phosphate (PHMG)-induced ...
Hyeon-Young Kim, Min-Seok Kim, Sung-Hwan Kim, Doin Joen, Kyuhong Lee   +4 more
doaj   +1 more source

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy

Science, 2015
Gut microbes affect immunotherapy The unleashing of antitumor T cell responses has ushered in a new era of cancer treatment. Although these therapies can cause dramatic tumor regressions in some patients, many patients inexplicably see no benefit.
A. Sivan, L. Corrales, N. Hubert, Jason B. Williams, K. Aquino-Michaels, Z. Earley, Franco W. Benyamin, Yuk Man Lei, B. Jabri, M. Alegre, E. Chang, T. Gajewski   +11 more
semanticscholar   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

Research on the Mechanism and Material Basis of Corn (Zea mays L.) Waste Regulating Dyslipidemia

Pharmaceuticals
Corn (Zea mays L.) is an essential gramineous food crop. Traditionally, corn wastes have primarily been used in feed, harmless processing, and industrial applications. Except for corn silk, these wastes have had limited medicinal uses. However, in recent
Xiaodong Wang, Lewei Cao, Jiajun Tang, Jiagang Deng, Erwei Hao, Gang Bai, Pei Ling Tang, Jieyi Yang, Huaying Li, Lihao Yao, Cuiwei He, Xiaotao Hou   +11 more
doaj   +1 more source