Results 91 to 100 of about 8,924,877 (409)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Evaluation of Student Perceived Self-Efficacy With the Implementation of a Problem-Based Learning Module [PDF]

, 2007
To facilitate the graduation of competent registered nurses, healthcare educators must create learning environments that foster content expertise, problem solving, collaboration, and refined learning skills.
Romero, Joel David
core   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Collective efficacy belief, within-group agreement, and performance quality among instrumental chamber ensembles [PDF]

, 2018
We examined collective efficacy beliefs, including levels of within - group agreement and correlation with performance quality, of instrumental chamber ensembles (70 musicians, representing 18 ensembles).
Hendricks, Karin, Ray, James
core  

Control efficacy of complex networks [PDF]

, 2016
Acknowledgements W.-X.W. was supported by CNNSF under Grant No. 61573064, and No. 61074116 the Fundamental Research Funds for the Central Universities and Beijing Nova Programme, China. Y.-C.L.
Gao, Xin-Dong, Lai, Ying-Cheng, Wang, Wen-Xu   +2 more
core   +1 more source

Dupilumab Efficacy and Safety in Moderate‐to‐Severe Uncontrolled Asthma

New England Journal of Medicine, 2018
BACKGROUND Dupilumab is a fully human anti–interleukin‐4 receptor α monoclonal antibody that blocks both interleukin‐4 and interleukin‐13 signaling. We assessed its efficacy and safety in patients with uncontrolled asthma.
M. Castro, J. Corren, I. Pavord, J. Maspero, S. Wenzel, K. Rabe, W. Busse, L. Ford, L. Sher, M. Fitzgerald, C. Katelaris, Y. Tohda, Bingzhi Zhang, H. Staudinger, G. Pirozzi, N. Amin, M. Ruddy, B. Akinlade, A. Khan, J. Chao, R. Martincova, N. Graham, J. Hamilton, B. Swanson, N. Stahl, G. Yancopoulos, A. Teper   +26 more
semanticscholar   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Exploring the Therapeutic Potential of Bupleurum in Medical Treatment: A Comprehensive Overview

Pharmaceuticals
Bupleurum is a Chinese medicinal material widely used in clinical practice. Its medicinal component is the dried roots of either the Umbrella plant Bupleurum chinense DC or Bupleurum scorzonerifolium Willd.
Yu Tian, Jiageng Guo, Xinya Jiang, Hongyu Lu, Jinling Xie, Fan Zhang, Zhengcai Du, Erwei Hao   +7 more
doaj   +1 more source

Comparison of asthma phenotypes in OVA-induced mice challenged via inhaled and intranasal routes

BMC Pulmonary Medicine, 2019
Background The respiratory system is exposed to various allergens via inhaled and intranasal routes. Murine models of allergic lung disease have been developed to clarify the mechanisms underlying inflammatory responses and evaluate the efficacy of novel
Dong Im Kim, Mi-Kyung Song, Kyuhong Lee
doaj   +1 more source

Social threat appeals in commercial advertising: the moderating impact of perceived level of self-efficacy and self-esteem on advertising effectiveness [PDF]

, 2015
This study investigates the impact of the level of fear evoked by an advertisement (for deodorant) framing a threatening social situation. Where the effectiveness of threat appeals has been investigated extensively in health communication, this study ...
Cauberghe, Veroline, Faseur, Tine, Hudders, Liselot   +2 more
core   +1 more source