Results 21 to 30 of about 5,135,675 (370)

miR-1258 Attenuates Tumorigenesis Through Targeting E2F1 to Inhibit PCNA and MMP2 Transcription in Glioblastoma

Frontiers in Oncology, 2021
MicroRNAs are a group of endogenous small non-coding RNAs commonly dysregulated in tumorigenesis, including glioblastoma (GBM), the most malignant brain tumor with rapid proliferation, diffuse invasion, and therapeutic resistance.
Hongkun Qin, Yanping Gui, Rong Ma, Heng Zhang, Yabing Guo, Yuting Ye, Jia Li, Li Zhao, Yajing Wang   +8 more
doaj   +1 more source

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

Science, 2018
Good bacteria help fight cancer Resident gut bacteria can affect patient responses to cancer immunotherapy (see the Perspective by Jobin). Routy et al. show that antibiotic consumption is associated with poor response to immunotherapeutic PD-1 blockade ...
B. Routy, E. Le Chatelier, L. Derosa, Connie P. M. Duong, M. Alou, Romain Daillère, A. Fluckiger, M. Messaoudene, C. Rauber, M. Roberti, Marine Fidelle, C. Flament, V. poirier-colame, P. Opolon, C. Klein, Kristina Iribarren, L. Mondragón, N. Jacquelot, B. Qu, Gladys Ferrere, C. Clémenson, L. Mezquita, J. R. Masip, C. Naltet, S. Brosseau, C. Kaderbhai, C. Richard, H. Rizvi, F. Levenez, N. Galleron, Benoît Quinquis, N. Pons, B. Ryffel, V. Minard-Colin, P. Gonin, J. Soria, E. Deutsch, Y. Loriot, F. Ghiringhelli, G. Zalcman, F. Goldwasser, B. Escudier, M. Hellmann, A. Eggermont, D. Raoult, L. Albiges, G. Kroemer, L. Zitvogel   +47 more
semanticscholar   +1 more source

Bone marrow mesenchymal stem cell-derived exosomal microRNA regulates microglial polarization [PDF]

PeerJ, 2023
Objective This study aimed to explore the effects of bone marrow mesenchymal stem cell (BMSC)-derived exosomal miR-146a-5p on microglial polarization and the potential underlying mechanisms in oxygen-glucose deprivation (OGD)-exposed microglial cells ...
Xianwei Huang, Xiong Liu, Jiaqi Zeng, Penghui Du, Xiaodong Huang, Jiyan Lin   +5 more
doaj   +2 more sources

Efficacy of Topiramate [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1998
ABSTRACT:In controlled clinical trials, topiramate (TopamaxR) has demonstrated efficacy in refractory patients with complex partial seizures and secondarily generalized tonic-clonic seizures. Approximately 45 percent of 534 patients had a ≥ 50 percent reduction in seizure frequency.
openaire   +3 more sources

Correlates of Programmer Efficacy and Their Link to Experience: A Combined EEG and Eye-Tracking Study [PDF]

, 2023
Background: Despite similar education and background, programmers can exhibit vast differences in efficacy. While research has identified some potential factors, such as programming experience and domain knowledge, the effect of these factors on programmers' efficacy is not well understood. Aims: We aim at unraveling the relationship between efficacy
arxiv   +1 more source

Biodistribution and pharmacokinetic evaluation of Korean Red Ginseng components using radioisotopes in a rat model

Journal of Ginseng Research, 2023
Background: Although many studies have evaluated the efficacy and pharmacokinetics of Korean Red Ginseng (KRG) components (Rg1, Rb1, Rg3, Rd, etc.), few have examined the in vivo pharmacokinetics of the radiolabeled components.
Sung-Won Kim, Byung-Cheol Han, Seung-Ho So, Chang-Kyun Han, Gyo In, Chae-Kyu Park, Sun Hee Hyun   +6 more
doaj  

Anti-Osteoporotic Effect of Viscozyme-Assisted Polysaccharide Extracts from Portulaca oleracea L. on H₂O₂-Treated MC3T3-E1 Cells and Zebrafish

Separations, 2022
This study aims to screen and characterize the protective effect of polysaccharides from Portulaca oleracea L. (POP) against H2O2-stimulated osteoblast apoptosis in vivo and in vitro.
Yunhua Fu, Xuan Hu, Dongyue Zhou, Xue Li, Xingyu Tao, Di Yang, Fei Zheng, Yulin Dai, Hao Yue   +8 more
doaj   +1 more source

Self-efficacy: toward a unifying theory of behavioral change.

Psychology Review, 1977
The present article presents an integrative theoretical framework to explain and to predict psychological changes achieved by different modes of treatment.
A. Bandura
semanticscholar   +1 more source

Declining responsiveness of childhood Plasmodium falciparum infections to artemisinin-based combination treatments ten years following deployment as first-line antimalarials in Nigeria

Infectious Diseases of Poverty, 2019
Background The development and spread of artemisinin-resistant Plasmodium falciparum malaria in Greater Mekong Subregion has created impetus for continuing global monitoring of efficacy of artemisinin-based combination therapies (ACTs).
Akintunde Sowunmi, Godwin Ntadom, Kazeem Akano, Folasade O. Ibironke, Adejumoke I. Ayede, Chimere Agomo, Onikepe A. Folarin, Grace O. Gbotosho, Christian Happi, Stephen Oguche, Henrietta U. Okafor, Martin Meremikwu, Philip Agomo, William Ogala, Ismaila Watila, Olugbenga Mokuolu, Finomo Finomo, Joy C. Ebenebe, Nma Jiya, Jose Ambe, Robinson Wammanda, George Emechebe, Wellington Oyibo, Francis Useh, Temitope Aderoyeje, Titilope M. Dokunmu, Omobolaji T. Alebiosu, Sikiru Amoo, Oluwabunmi K. Basorun, Olubunmi A. Wewe, Chukwuebuka Okafor, Odafe Akpoborie, Bayo Fatunmbi, Elsie O. Adewoye, Nnenna M. Ezeigwe, Ayoade Oduola   +35 more
doaj   +1 more source

Characterization of Limosilactobacillus reuteri KGC1901 Newly Isolated from Panax ginseng Root as a Probiotic and Its Safety Assessment

Fermentation, 2023
In this study, we determined the probiotic properties and safety of Limosilactobacillus reuteri KGC1901 isolated from Korean Panax ginseng root. This strain was identified based on its 16s rRNA sequence, and the absence of genes related to antibiotic ...
Hye-Young Yu, Mijin Kwon, Yun-Seok Lee, Seung-Ho Lee, Sang-Kyu Kim   +4 more
doaj   +1 more source