Results 71 to 80 of about 8,614,944 (389)

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Moments of clarity : a study of higher education teachers' professional learning experiences and the transformational process of change in self-efficacy development : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Education at Massey University, Manawatū, New Zealand [PDF]

, 2017
This qualitative longitudinal study sought to understand ‘aha’ moments experienced by a group of early career higher education teachers in Aotearoa New Zealand and the role those moments played in the transformational process of change in teacher self ...
Percy, Bridget Marie
core  

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Therapeutic effects of a combination of Chinese quince and Saururus chinensis extract on allergic airway inflammation in an ovalbumin-induced asthma mouse model

Frontiers in Nutrition
BackgroundAllergic asthma involves chronic inflammation, airway remodeling, and hyperresponsiveness. Inhaled corticosteroids combined with long-acting β2 agonists are effective; however, some patients experience side effects, highlighting the need for ...
Hye Jin Lee, Ki Cheon Kim, Woo Jin Lee, Hyo Jung Nam, Su Jin Ryu, Seon Hyeok Kim, Won Jun Kim, Jae Won Yoon, Tae-Hee Lee, Pan-Young Jeong   +9 more
doaj   +1 more source

Effect of Self-Efficacy Enhancing Education Program on Family Caregivers\u27 Competencies in Caring for Patients with Mild Traumatic Brain Injury in YOGYAKARTA, Indonesia [PDF]

, 2014
Purpose: This study was conducted to examine the effect of a self-efficacy enhancing education program on family caregivers\u27 competencies regarding perceived confidence and performance in caring for patients with mild TBI in Yogyakarta, Indonesia ...
Firmawati, E. (Erfin), Kitrungrote, L. (Luppana), Songwathana, P. (Praneed)   +2 more
core  

Efficacy of Tocilizumab in Patients Hospitalized with Covid-19

New England Journal of Medicine, 2020
Background The efficacy of interleukin-6 receptor blockade in hospitalized patients with coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is unclear.
J. Stone, M. Frigault, Naomi Serling-Boyd, Ana D. Fernandes, Liam Harvey, A. Foulkes, Nora K. Horick, B. Healy, R. Shah, A. Bensaci, A. Woolley, S. Nikiforow, N. Lin, M. Sagar, H. Schrager, D. Huckins, M. Axelrod, M. Pincus, J. Fleisher, C. Sacks, M. Dougan, C. North, Y. Halvorsen, Tara K Thurber, Z. Dagher, Allison K. Scherer, Rachel S Wallwork, A. Kim, S. Schoenfeld, Pritha Sen, T. Neilan, C. Perugino, S. Unizony, Deborah S Collier, M. Matza, Janeth M Yinh, Kathryn A Bowman, Eric A. Meyerowitz, A. Zafar, Z. Drobni, M. Bolster, M. Kohler, K. D’Silva, J. Dau, M. M. Lockwood, Caroline Cubbinson, B. Weber, M. Mansour   +47 more
semanticscholar   +1 more source

Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine

New England Journal of Medicine, 2021
Background The safety and efficacy of the AZD1222 (ChAdOx1 nCoV-19) vaccine in a large, diverse population at increased risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the United States, Chile, and Peru has not been ...
A. Falsey, M. Sobieszczyk, I. Hirsch, Stephanie Sproule, M. Robb, L. Corey, K. Neuzil, William W Hahn, Julie Hunt, M. Mulligan, C. Mcevoy, E. Dejesus, Michael Hassman, S. Little, B. Pahud, A. Durbin, P. Pickrell, E. Daar, L. Bush, Joel Solis, Quito Osuna Carr, Temitope Oyedele, S. Buchbinder, J. Cowden, Sergio L Vargas, Alfredo Guerreros Benavides, R. Call, M. Keefer, B. Kirkpatrick, J. Pullman, T. Tong, Margaret Brewinski Isaacs, David C. Benkeser, H. Janes, M. Nason, Justin A. Green, E. Kelly, Jill Maaske, N. Mueller, Kathryn Shoemaker, Therese Takas, Richard P. Marshall, M. Pangalos, T. Villafana, Antonio Gonzalez-Lopez   +44 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

A Study of the Wellbeing of Siblings of Children with Autism Spectrum Disorders: Sibling Efficacy, Positive and Negative Affect, and Coping Strategies [PDF]

, 2018
Autism spectrum disorders (ASD) include pervasive developmental disorders characterised by communication deficits, difficulty with social understanding, and repetitive behaviors.
Habelrih, Emily Anne, Hicks, Richard E., Vanstone, Daisy   +2 more
core   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source