Results 61 to 70 of about 773,336 (309)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

The Impact of Organizational Change on Firm Performance—Analysis Based on SCM Modeling

SAGE Open
Based on structural equation modeling, the impact of changes in organizational framework on firm performance and the intervention function of operational efficiency are scrutinized.
Lai Zhihuang, Zhang yuchen
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Organizational tension between static and dynamic efficiency, The [PDF]

Efficiency has been defined in at least two different ways: in terms of the refinement of existing products, processes or capabilities (static efficiency) or the development of new ones (dynamic efficiency).
Ghemawat, Pankaj, Ricart, Joan E.
core  

Customization Or Conformity? An Institutional And Network Perspective On The Content And Consequences Of TQM Adoption [PDF]

, 1997
This study develops a theoretical framework that integrates institutional and network perspectives on the form and consequences of administrative innovations.
Gulati, R., Shortell, S. M., Westphal, J. D.   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Impact of Leadership, Organizational Culture, And Organizational Structure on the Performance of the Finance Department at Aruna Senggigi Hotel

Indonesian Interdisciplinary Journal of Sharia Economics
Tourism is a vital economic sector, especially in destinations like Lombok, Known for its halal and sustainable tourism. Aruna Senggigi Hotel, one of the hotels implementing this concept, faces challenges in maintaining financial management efficiency ...
Lalu Imam Hardiansyah, Lalu Takdir Jumaidi   +1 more
doaj   +1 more source

Some determinants of organizational success [PDF]

Organizational efficiency and productivity determined by variables associated with economics, psychology, and ...
Becker, S. W., Stafford, F.
core   +1 more source

Towards Data Protection Compliance [PDF]

, 2010
Privacy and data protection are fundamental issues nowadays for every organization. This paper calls for the development of methods, techniques and infrastructure to allow the deployment of privacy-aware IT systems, in which humans are integral part of ...
Etalle, Sandro, Petkovic, Milan, Zannone, Nicola   +2 more
core   +2 more sources