Results 81 to 90 of about 294,257 (261)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Efficient algorithms for common transversals
Information Processing Letters, 1987 Abstract Suppose we are given a set S of n (possibly intersecting) simple objects in the plane such that, for every pair of objects in S, the intersection of the boundaries of these two objects has O(1) connected components. We consider the problem of determining whether there exists a straight line that goes through every object in S. We give an O(n
Atallah, Mikhail J., Bajaj, Chanderjit
openaire +3 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Efficient algorithms for the discovery of gapped factors
Algorithms for Molecular Biology, 2011 Background The discovery of surprisingly frequent patterns is of paramount interest in bioinformatics and computational biology. Among the patterns considered, those consisting of pairs of solid words that co-occur within a prescribed maximum distance ...
Pizzi Cinzia +2 more
doaj +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Efficient 3D Model Simplification Algorithms Based on OpenMP
MathematicsEfficient simplification of 3D models is essential for mobile and other resource-constrained application scenarios. Industrial 3D assemblies, typically composed of numerous components and dense triangular meshes, often pose significant challenges in ...
Han Chang +5 more
doaj +1 more source
Communication Efficient Algorithms for Bounding and Approximating the Empirical Entropy in Distributed Systems. [PDF]
Entropy (Basel), 2022 Shahar A, Alfassi Y, Keren D.
europepmc +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Efficient Algorithms Unlock Understanding of Clonal Evolution in Cancer. [PDF]
Blood Cancer Discov, 2022 Miller CA.
europepmc +1 more source