Results 101 to 110 of about 2,813,925 (355)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

LEESOLA: A Locally Made Energy Efficient Solar Tracking System for Home Use

Techne
A solar tracking system is used to orient solar reflectors, photovoltaic panels, and other solar energy harvesting equipment toward the sun mainly to maximize energy output.
Benjamin Kommey, Elvis Tamakloe, Agbesi Jerry, Darkwa Wassem, Normenyo Gershon Elikem   +4 more
doaj   +1 more source

IMPROVING ENERGY EFFICIENCY IN BUILDINGS USING MICROGRIDS

Elektronički časopis građevinskog fakulteta Osijek, 2015
Modern society has a growing need for the electricity. To protect the environment, future energy demand must be met with more environmentally friendly technologies, such as renewable energy sources. Because of its vast availability, solar radiation has been used for decades to generate electricity through photovoltaic systems (PV) for residential ...
Primorac, Mario, Šipoš, Mario, Klaić, Zvonimir   +2 more
openaire   +2 more sources

Fermionic Vacuum Energy from a Nielsen-Olesen Vortex

, 2003
We calculate the vacuum energy of a spinor field in the background of a Nielsen-Olesen vortex. We use the method of representing the vacuum energy in terms of the Jost function on the imaginary momentum axis. Renormalization is carried out using the heat
Ana Achucarro, Bum-Hoon Lee, D.V. Vassilevich, Dmitri Diakonov, Dmitri Diakonov, Gerald V. Dunne, Holger Bech Nielsen, Holger Gies, Holger Gies, I. Drozdov, J.D. Lange, J.R. Schmidt, Kurt Langfeld, M. Bordag, M. Bordag, M. Bordag, M. Bordag, M. Bordag, M. Bordag, M. Bordag, M.P. Fry, Marco Scandurra, Martin Groves, Michael Bordag, N. Graham, Noah Graham, Pavlos Pasipoularides, Pavlos Pasipoularides, Y. Aharonov   +28 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

ENERGY EFFICIENCY IN THE FOOD RETAIL [PDF]

Business Excellence and Management, 2016
In this paper the emphasis is put on the specifics of energy efficiency impact on the profitability of the service sector, with special insight into food retail. The theoretical and methodological presentations are illustrated by applying the comparative
Radojko LUKIC
doaj  

Quantifying benefits of energy efficient house design through monitoring of specified air quality and household energy activity

Journal of Energy in Southern Africa, 2017
Energy efficient building design aims to use passive design principles such as orientation, insulation, materials and surrounding area layout to minimise the need for active space heating or cooling.
M Wentzel
doaj   +1 more source

Energy‐efficient Electrochemical Hydrogen Production Combined with Biomass Oxidation Using Polyoxometalate and Metal Salts [PDF]

, 2023
Weizhuo Xu, Bingjie Zhou, Qing Wang, Guohao Xu, Ning Li, Wei Liu, Z. Conrad Zhang   +6 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source