Results 141 to 150 of about 272,567 (316)

Bilirubin Decreases Macrophage Cholesterol Efflux and ATP‐Binding Cassette Transporter A1 Protein Expression

, 2017
Background Mild but chronically elevated circulating unconjugated bilirubin is associated with reduced total and low‐density lipoprotein cholesterol concentration, which is associated with reduced cardiovascular disease risk.
Atanasov, AG, Angela Ladurner, Wang, Dongdong, Heiß, Elke, Mölzer, C, Ladurner, A, Dirsch, Verena, Atanasov, Atanas G., Wang, D, Andrew Bulmer, Ladurner, Angela, Wagner, KH, Verena M. Dirsch, Bulmer, Andrew C., Anela Tosevska, Mölzer, Christine, Marlies Wallner, Karl‐Heinz Wagner, Tosevska, Anela, Wallner, Marlies, Christine Mölzer, Wagner, Karl-Heinz, Tosevska, A, Dirsch, VM, Wallner, M, Elke H. Heiß, Dongdong Wang, Heiß, EH, Atanas G. Atanasov, Bulmer, A   +29 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Cholesterol metabolism: physiological regulation and diseases

MedComm
Cholesterol homeostasis is crucial for cellular and systemic function. The disorder of cholesterol metabolism not only accelerates the onset of cardiovascular disease (CVD) but is also the fundamental cause of other ailments.
Jiarui Guo, Silong Chen, Ying Zhang, Jinxia Liu, Luyang Jiang, Lidan Hu, Ke Yao, Yibo Yu, Xiangjun Chen   +8 more
doaj   +1 more source

Measuring glymphatic function: Assessing the toolkit

Neural Regeneration Research
Glymphatic flow has been proposed to clear brain waste while we sleep. Cerebrospinal fluid moves from periarterial to perivenous spaces through the parenchyma, with subsequent cerebrospinal fluid drainage to dural lymphatics.
Koushikk Ayyappan, Lucas Unger, Philip Kitchen, Roslyn M. Bill, Mootaz M. Salman   +4 more
doaj   +1 more source

A creatine efflux transporter in oligodendrocytes

The FEBS Journal
Creatine is essential for ATP regeneration in energy‐demanding cells. Creatine deficiency results in severe neurodevelopmental impairments. In the brain, creatine is synthesized locally by oligodendrocytes to supply neighboring neurons. Neuronal uptake is mediated by SLC6A8.
Svenja Flögel, Miriam Strater, Dietmar Fischer, Dirk Gründemann   +3 more
openaire   +2 more sources

PIN proteins perform a rate-limiting function in cellular auxin efflux

, 2006
Intercellular flow of the phytohormone auxin underpins multiple developmental processes in plants. Plant-specific pin-formed ( PIN) proteins and several phosphoglycoprotein (PGP) transporters are crucial factors in auxin transport - related development ...
Mravec, Jozef, Seifertova, Daniela, Tadele, Zerihun, Fink, Gerald, Bouchard, Rodolphe, Wisniewska, Justyna, Kubes, Martin, Perry, Lucie, Covanova, Milada, Zazimalova, Eva, Luschnig, Christian, Abas, Melinda, Murphy, Angus S, Petrasek, Jan, Lee, Ok Ran, Skupa, Petr, Dhonukshe, Pankaj, Friml, Jiri, Murphy, Angus, Benkova, Eva, Geisler, Markus, Krecek, Pavel, Blakeslee, Joshua J, Blakeslee, Joshua, Fink, Gerald R   +24 more
core   +1 more source

Architected Inverse Nacre Hydrogels With High Strength and Crack‐Insensitive Toughness

Advanced Science, EarlyView.
Hydrogels hold promise for biomedical and engineering applications, yet their practical use is fundamentally limited by the strength‐toughness trade‐off and poor fatigue resistance. In this study, a bioinspired inverse nacre architecture constructed via a scalable thermo‐calendering process is introduced, which overcomes these classic limitations ...
Haidi Wu, Qin Su, Cheng Guan, Biwang Pan, Wenjie Hu, Jun Yan, Yifan Feng, Longcheng Tang, Xuewu Huang, Jiefeng Gao, Wancheng Gu   +10 more
wiley   +1 more source

Shared resistance and virulence of Klebsiella pneumoniae from human and meat sources: A one health perspective

Open Veterinary Journal
Background: Klebsiella pneumoniae is a Gram-negative bacterium that causes several infections, particularly in hospitals and food-borne settings. Aim: This study aimed to investigate the presence of K. pneumoniae in human clinical samples and raw meat
Qasim Zamil Bneed, Noor Adil Abood, Orooba Meteab Faja, Baneen Najm Alhasanawi, Zahraa Sameer, Maryam Ali Alzubaidy   +5 more
doaj   +1 more source

Plant Metabolites as Potential Agents That Potentiate or Block Resistance Mechanisms Involving β-Lactamases and Efflux Pumps

The dramatic increase in antimicrobial resistance (AMR) in recent decades has created an urgent need to develop new antimicrobial agents and compounds that can modify and/or block bacterial resistance mechanisms.
Muhammad Jawad Zai, Cock, Ian Edwin, Cheesman, Matthew James, Zai, Muhammad Jawad, Ian Edwin Cock, Matthew James Cheesman   +5 more
core   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source