Results 261 to 270 of about 427,575 (339)

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

p38 inhibition restores chemosensitivity of tumor cells by disrupting oligomerized breast cancer resistance protein membrane trafficking. [PDF]

iScience
Pan Y, Zhu Z, Zhu Y, Hu T, Zhang Z, Fan H, Yu S, Wei Z, Wang A, Lu Y, Chen W.   +10 more
europepmc   +1 more source

Reviewer #3 (Public Review): Astrocyte aquaporin mediates a tonic water efflux maintaining brain homeostasis

Cuong Pham, Yuji Komaki, Anna Deàs-Just, Benjamin Le Gac, Christine Mouffle, Clara Franco, Vincent Vialou, Tomokazu Tsurugizawa, Bruno Cauli, Dongdong Li   +9 more
openalex   +1 more source

DR5 Governs Compound Exocytosis in Colonic Goblet Cells via TATA‐Box Binding Protein‐Dependent Bestrophin‐2 Transcriptional Regulation

Advanced Science, EarlyView.
DR5 knockout exhibits a thinner colonic mucus layer, leading to mild dysbiosis, increased susceptibility to Citrobacter rodentium invasion, and exacerbated epithelial injury. Mechanistically, DR5 binds transcription factor TBP, which regulates the expression of gene Best2 via its promoter.
Ying Wang, Xinyun Li, Yong Wang, Chuhe Yang, Xiaopei Gao, Ke Zhu, Yihang Ren, Jingxin Li, Chuanyong Liu, Bing Xue   +9 more
wiley   +1 more source

New Insights into TFEB SUMOylation and Its Role in Lipid Metabolism and Cardiovascular Disease. [PDF]

Int J Mol Sci
Meng Q, Li CG, Chen X, Cao R, Zhang H, Wang P, Jin J.   +6 more
europepmc   +1 more source

Localization of an apolipoprotein A-I epitope critical for lipoprotein-mediated cholesterol efflux from monocytic cells.

, 1994
Carole L. Banka, Audrey S. Black, Linda K. Curtiss   +2 more
openalex   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Efflux pump knockout minimizes crosstalk and boosts response in transcription factor-based biosensors. [PDF]

J Biol Eng
Lee J, Yoo BH, Jeon E, Kong H, Rha E, Shin J, Lee H, Kim H, Lee DH, Kwon KK, Lee SG.   +10 more
europepmc   +1 more source

Transport Mechanism of Anthracycline Derivatives in Human Leukemia Cell Lines: Uptake and Efflux of Daunorubicin and Doxorubicin in HL60 and Its Resistant Cells and Comparison with Those of Pirarubicin.

, 1996
Kazuki Nagasawa, Toshiki Natazuka, Masako Nomiyama, Noriaki Ohnishi, Teruyoshi Yokoyama   +4 more
openalex   +2 more sources

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source