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Integrative pan-resistome and transcriptomic characterization reveals differential gene expression signatures in carbapenem-resistant Acinetobacter baumannii: Insights into efflux pump regulation and therapeutic targeting strategies. [PDF]

PLoS One
Gopikrishnan M, Doss C GP.
europepmc   +1 more source

Transient AdeABC-mediated eravacycline resistance in carbapenem-resistant Acinetobacter baumannii ST2: a mutation-independent efflux pump adaptation. [PDF]

Ann Clin Microbiol Antimicrob
Yang X, He N, Haque A, Mai Y, Wang J, Xiao S, Zhuo C.   +6 more
europepmc   +1 more source

Harness Behavioural Analysis for Unpacking the Bio-Interpretability of Pathology Foundation Models

Hu Y, Batchkala G, Gaitskell K, Domingo E, Li B, Zhang T, Li Z, Friedrich M, Woodcock D, Verrill C, Rittscher J.   +10 more
europepmc   +1 more source

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Transintestinal cholesterol efflux

Current Opinion in Lipidology, 2010
Regulation of cholesterol homeostasis is a complex interplay of a multitude of metabolic pathways situated in different organs. The liver plays a central role and has received most attention of the research community. In this review, we discuss recent progress in the understanding of the emerging role of the intestine in cholesterol transport.In recent
Astrid E, van der Velde, Gemma, Brufau, Albert K, Groen   +2 more
openaire   +5 more sources

Antibiotic efflux mechanisms

Current Opinion in Infectious Diseases, 1999
Bacterial genomes sequenced to date almost invariably contain genes apparently coding for multidrug efflux pumps, and the yeast genome contains more than 30 putative multidrug efflux genes. Thus it is not surprising that multidrug efflux is a major cause of intrinsic drug resistance in many microorganisms, and plays an even more prominent role in ...
H, Nikaido, H I, Zgurskaya
openaire   +2 more sources