Results 31 to 40 of about 426,896 (336)

Phylogenetic analysis reveals an ancient gene duplication as the origin of the MdtABC efflux pump. [PDF]

, 2020
The efflux pumps from the Resistance-Nodulation-Division family, RND, are main contributors to intrinsic antibiotic resistance in Gram-negative bacteria. Among this family, the MdtABC pump is unusual by having two inner membrane components.
Górecki, Kamil, McEvoy, Megan M
core   +2 more sources

Review of: "Inhibiting Efflux Pumps and Resistance Mechanisms: A Mini Review" [PDF]

, 2023
Claus‐Michael Lehr
openalex   +3 more sources

Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages[S]

Journal of Lipid Research, 2014
Hydrolysis of intracellular cholesteryl ester (CE) is the rate-limiting step in the efflux of cholesterol from macrophage foam cells. In mouse peritoneal macrophages (MPMs), this process is thought to involve several enzymes: hormone-sensitive lipase ...
Kent Sakai, Masaki Igarashi, Daisuke Yamamuro, Taichi Ohshiro, Shuichi Nagashima, Manabu Takahashi, Bolormaa Enkhtuvshin, Motohiro Sekiya, Hiroaki Okazaki, Jun-ichi Osuga, Shun Ishibashi   +10 more
doaj   +1 more source

Efflux, Signaling and Warfare in a Polymicrobial World

Antibiotics, 2023
The discovery void of antimicrobial development has occurred at a time when the world has seen a rapid emergence and spread of antimicrobial resistance, the ‘perfect storm’ as it has often been described.
Ay’sha Moore-Machacek, Antje Gloe, Niall O’Leary, F. Jerry Reen   +3 more
doaj   +1 more source

Using cellular fitness to map the structure and function of a major facilitator superfamily effluxer. [PDF]

, 2017
The major facilitator superfamily (MFS) effluxers are prominent mediators of antimicrobial resistance. The biochemical characterization of MFS proteins is hindered by their complex membrane environment that makes in vitro biochemical analysis challenging.
Bennett, Matthew R, Gomez, Marcella M, Kalvapalle, Prashant, O'Brien-Gilbert, Erin, Perez, Anisha M, Shamoo, Yousif   +5 more
core   +2 more sources

Smart pH- and Temperature-Sensitive Micelles Based on Chitosan Grafted with Fatty Acids to Increase the Efficiency and Selectivity of Doxorubicin and Its Adjuvant Regarding the Tumor Cells

Pharmaceutics, 2023
The main factors that determine the low effectiveness of chemotherapy are the low target bioavailability of antitumor drugs and the efflux process. In attempts to overcome this problem, several approaches are proposed here.
Igor D. Zlotnikov, Dmitriy A. Streltsov, Alexander A. Ezhov, Elena V. Kudryashova   +3 more
doaj   +1 more source

The Impact of Triclosan on the Spread of Antibiotic Resistance in the Environment [PDF]

, 2015
Triclosan (TCS) is a commonly used antimicrobial agent that enters wastewater treatment plants (WWTPs) and the environment. An estimated 1.1 × 105 to 4.2 × 105 kg of TCS are discharged from these WWTPs per year in the United States.
Carey, Daniel E., McNamara, Patrick J.
core   +3 more sources

Understanding adaptation to fluconazole: comparative insights into tolerance and resistance in Saccharomyces cerevisiae and Candida albicans

Frontiers in Cellular and Infection Microbiology
IntroductionAntifungal resistance and tolerance are distinct responses exhibited by fungi when exposed to drugs. While considerable research has focused on azole tolerance in the human pathogen Candida albicans, studies in other fungal species remain ...
Lijun Zheng, Yubo Dong, Jing Wang, Yonghui Jia, Weifang Wang, Yi Xu, Yi Xu, Liangsheng Guo   +7 more
doaj   +1 more source

A Major Facilitator Superfamily Transporter Regulated by the Stress-Responsive Transcription Factor Yap1 Is Required for Resistance to Fungicides, Xenobiotics, and Oxidants and Full Virulence in Alternaria alternata

Frontiers in Microbiology, 2018
Alternaria alternata relies on the ability to produce a host-selective toxin and to detoxify reactive oxygen species to successfully colonize the host. An A.
Hsien-Che Lin, Pei-Ling Yu, Li-Hung Chen, Hsieh-Chin Tsai, Kuang-Ren Chung   +4 more
doaj   +1 more source

Herb-Drug Pharmacokinetic Interactions: Transport and Metabolism of Indinavir in the Presence of Selected Herbal Products

Molecules, 2015
Patients receiving anti-retroviral drug treatment are sometimes simultaneously taking herbal remedies, which may result in pharmacokinetic herb-drug interactions.
Carlemi Calitz, Chrisna Gouws, Joe Viljoen, Jan Steenekamp, Lubbe Wiesner, Efrem Abay, Josias Hamman   +6 more
doaj   +1 more source