Results 61 to 70 of about 122,546 (256)

Function and Inhibitory Mechanisms of Multidrug Efflux Pumps

Frontiers in Microbiology, 2021
Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug
Kunihiko Nishino, Seiji Yamasaki, Ryosuke Nakashima, Martijn Zwama, Mitsuko Hayashi-Nishino   +4 more
doaj   +1 more source

Microbial Communities of the Providence River [PDF]

, 2015
The Providence River has been industrialized for over one-hundred years. Industries such as oil storage and metal recycling facilities have left high levels of pollutant metals, including lead (Pb), in the soil and water.
Kratch, Jacqueline
core   +1 more source

Biofilm Formation and the Role of Efflux Pumps in ESKAPE Pathogens

Microorganisms
Nosocomial infections caused by ESKAPE pathogens represent a significant burden to global health. These pathogens may exhibit multidrug resistance (MDR) mechanisms, of which mechanisms such as efflux pumps and biofilm formation are gaining significant ...
Trent R. Sorenson, Kira M. Zack, Suresh G. Joshi   +2 more
doaj   +1 more source

Comparative genomic analysis of Geobacter sulfurreducens KN400, a strain with enhanced capacity for extracellular electron transfer and electricity production [PDF]

, 2012
Peer ...
Aklujkar, Muktak, Butler, Jessica E, Lovley, Derek R, Young, Nelson D   +3 more
core   +4 more sources

Emergence of a multidrug resistance efflux pump with carbapenem resistance gene blaVIM-2 in a Pseudomonas putida megaplasmid of migratory bird origin [PDF]

, 2021
Ruichao Li, Kai Peng, Xia Xiao, Yuan Liu, Daxin Peng, Zhiqiang Wang   +5 more
openalex   +1 more source

Bacterial efflux pump inhibitors from natural sources [PDF]

Journal of Antimicrobial Chemotherapy, 2006
The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the discovery of new antibacterials and resistance-modifying agents. Since the initial discovery of bacterial efflux pumps in the 1980s, many have been characterized in community- and hospital-acquired Gram-positive and Gram-negative pathogens, such as Staphylococcus ...
Stavri, Michael, Piddock, Laura J. V., Gibbons, Simon   +2 more
openaire   +3 more sources

Enhanced Efficacy of Ciprofloxacin and Tobramycin against Staphylococcus aureus When Combined with Corydalis Tuber and Berberine through Efflux Pump Inhibition

Antibiotics
One way that bacteria develop antibiotic resistance is by reducing intracellular antibiotic concentrations through efflux pumps. Therefore, enhancing the efficacy of antibiotics using efflux pump inhibitors provides a way to overcome this type of ...
Yena Seo, Minjun Kim, Tae-Jong Kim
doaj   +1 more source

Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors [PDF]

, 2014
Efflux pumps of the resistance nodulation division (RND) superfamily, such as AcrB, make a major contribution to multidrug resistance in Gram-negative bacteria. The development of inhibitors of the RND pumps would improve the efficacy of current and next-
Nguyen, ST, Nikaido, H, Opperman, TJ, Ruggerone, P, Vargiu, AV   +4 more
core   +2 more sources

Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting. [PDF]

, 2019
The goal of the Sexually Transmitted Infection Clinical Trial Group's Antimicrobial Resistance (AMR) in Neisseria gonorrhoeae (NG) meeting was to assemble experts from academia, government, nonprofit and industry to discuss the current state of research,
Bristow, Claire C, Cristillo, Anthony D, Dillon, Jo-Anne, Dong, Huan, Grad, Yonatan H, Kirkcaldy, Robert D, Klausner, Jeffrey D, Lawrence, Kenneth, Morris, Sheldon R, Nicholas, Robert A, Oldach, David, Rice, Peter A, Shafer, William Maurice, Torrone, Elizabeth, Wi, Teodora E, Zhou, Pei   +15 more
core   +1 more source

Imipenem Induced Transcriptional Modulation of Multidrug Efflux Pumps and Porin Genes in Carbapenem Resistant Escherichia coli Isolates of Animal Origin [PDF]

, 2022
U. Jaiswal, A. Arun, Ashish Pratap Singh, Soumen Choudhury, Shyama N. Prabhu, Neeraj Kumar Gangwar   +5 more
openalex   +1 more source