Results 141 to 150 of about 997,958 (247)

A novel mechanism of action of ketoconazole: inhibition of the NorA efflux pump system and biofilm formation in multidrug-resistant Staphylococcus aureus

Infection and Drug Resistance, 2019
Rehab M Abd El-Baky,1,2 Tim Sandle,3 James John,4 Gamal El-Din AA Abuo-Rahma,5 Helal F Hetta6,71Department of Microbiology and Immunology, Faculty of Pharmacy, Minia University, Minia 61519, Egypt; 2Microbiology and Immunology Department, Faculty of ...
Abd El-Baky RM, Sandle T, John J, Abuo-Rahma GE, Hetta HF   +4 more
doaj  

Thioridazine Is an Efflux Pump Inhibitor in Mycobacterium avium Complex but of Limited Clinical Relevance. [PDF]

Antimicrob Agents Chemother, 2020
Ruth MM, Pennings LJ, Koeken VACM, Schildkraut JA, Hashemi A, Wertheim HFL, Hoefsloot W, van Ingen J.   +7 more
europepmc   +1 more source

Investigating & Improving the Drooping Curve of A Two-Stage Feed Pump [PDF]

, 2018
TutorialsA two-stage between-bearing pump of the upgraded material was supplied to replace the existing machine. The pump utilized a higher number of impeller blades to obtain higher efficiency at its design point, but exhibited a drooping head-flow ...
Tzuu Bin, Ng, Bin Ng, Tzuu
core  

Optimizing Cancer Vaccinations Using a Physiologically‐Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model

Advanced Science, EarlyView.
Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
Mohammad R. Nikmaneshi, Timothy P. Padera, Lance L. Munn   +2 more
wiley   +1 more source

Electronic‐State Programming of Ultrasmall CeO2 Switches H2O2 Activation From Radical to Bio‐Inspired Nonradical 1O2 Generation for Combating Antibiotic Resistance

Advanced Science, EarlyView.
A scalable synthesis of carbon‐supported ultrasmall CeO2 nanoparticles with precisely tunable Ce electron density is reported. Electron‐lean Ce sites activate H2O2 exclusively via a nonradical pathway, enabling efficient HOBr and 1O2 production analogous to bromoperoxidase for contaminant and antibiotic resistance removal.
Bo Yuan, Xinyu Wu, Yin‐Song Liao, Chao Zhao, Zhanping Xiao, Wanqing Dai, Jyh‐Pin Chou, Wenchao Peng, Jian Lin Chen, Pi‐Tai Chou, Yung‐Kang Peng   +10 more
wiley   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Complete Pathway Refactoring and Combinatorial Biosynthesis of Anthracyclines for Modulation of Histone Eviction and DNA Damage Bioactivities

Angewandte Chemie, EarlyView.
A synthetic biology platform was established for the complete refactoring of complex anthracycline biosynthetic pathways in Streptomyces coelicolor using standardized, chemically synthetic DNA parts. This modular construction enabled streamlined combinatorial biosynthesis, yielding novel analogs that decouple DNA damage from chromatin damage (histone ...
Rongbin Wang, Heli Tirkkonen, Sabina Y. van der Zanden, Larissa Ponomareva, Isaline Fagon, Leslie Fève, Kendall Paige, Courtney L. Brown, Nora Schwartz, Jacob Hecht, Jennifer Nguyen, Jon S. Thorson, Jacques Neefjes, S. Eric Nybo, Khaled A. Shaaban, Mikko Metsä‐Ketelä   +15 more
wiley   +2 more sources

A Compact Hollow Fiber Electrode Assembly Architecture for Continuous Electrochemical Marine Carbon Dioxide Removal

Advanced Energy Materials, EarlyView.
A coaxial, membrane‐integrated hollow fiber electrode assembly (HFEA) is developed for continuous marine carbon mineralization. By utilizing a sub‐millimeter inter‐electrode gap, the HFEA minimizes Ohmic losses, achieving 50% energy reduction and over 85% DIC removal.
Inhwan Park, Young Hun Lee, Jung Hun Lee, Seung‐Jeong Oh, T. Alan Hatton, Dong‐Yeun Koh   +5 more
wiley   +1 more source

Unveiling the Complete Biosynthetic Pathway of Azacitidine: A Rare 1,3,5‐Triazine Nucleoside Derived From GTP

Angewandte Chemie, EarlyView.
The azacitidine biosynthetic gene cluster (aza BGC) was identified by the resistance‐gene‐guided comparative genomics method in Streptomyces mobaraensis IPIO2. The complete biosynthetic pathway of azacitidine, which follows a “base‐first‐then‐glycosylation” logic, was elucidated through in vivo and in vitro experiments.
Dan Wang, Qingxu Meng, Lingqi Hua, Mengjun Sun, Qianjin Kang, Min‐Juan Xu, Linquan Bai   +6 more
wiley   +2 more sources

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source