Results 181 to 190 of about 59,758 (308)

Determination of imipenem efflux-mediated resistance in Acinetobacter spp., using an efflux pump inhibitor. [PDF]

Iran J Microbiol, 2019
Amiri G, Abbasi Shaye M, Bahreini M, Mafinezhad A, Ghazvini K, Sharifmoghadam MR.   +5 more
europepmc   +1 more source

Insights from meta‐analysis for efficient docosahexaenoic acid production in thraustochytrids through advanced cultivation and fermentation strategies

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract This systematic review examines strategies for docosahexaenoic acid (DHA) production by thraustochytrids, focusing on cultivation techniques, fermentation technologies, and carbon/nitrogen optimization to increase productivity. Among 169 eligible articles, the 100 most productive studies (0.7–10.3 g DHA L−1 per day) were analyzed. Quantitative
Jhiovana Cristielly Carrera Silva da Costa, Lucas Araújo Guimarães, Andre da Luz de Freitas, Luciana Porto de Souza Vandenberghe, Gilberto Vinícius de Melo Pereira, Carlos Ricardo Soccol, Hervé Louis Ghislain Rogez   +6 more
wiley   +1 more source

Synergistic effect of the hybrid compounds of cationic pillararene and an efflux pump inhibitor against Gram-negative bacteria. [PDF]

RSC Med Chem
Liu Y, Wu G, Zhu J, Jiang Y, Liu H.
europepmc   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

PANTAX: a phase Ib clinical trial of the efflux pump inhibitor SCO-101 in combination with gemcitabine and nab-paclitaxel in non-resectable or metastatic pancreatic cancer. [PDF]

Invest New Drugs
Shim S, Reinacher-Schick A, Kraeft AL, Per Pfeiffer, Tarpgaard LS, Ettrich TJ, Kestler A, Christensen S, Jandu H, Nawabi M, Roest NL, Damstrup L, Vestlev PM, Brünner N, Stenvang J, Ladekarl M.   +15 more
europepmc   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae. [PDF]

EMBO Mol Med
Vieira Da Cruz A, Jiménez-Castellanos JC, Börnsen C, Van Maele L, Compagne N, Pradel E, Müller RT, Meurillon V, Soulard D, Piveteau C, Biela A, Dumont J, Leroux F, Deprez B, Willand N, Pos KM, Frangakis AS, Hartkoorn RC, Flipo M.   +18 more
europepmc   +1 more source

Restoring colistin sensitivity in colistin-resistant E. coli: Combinatorial use of MarR inhibitor with efflux pump inhibitor. [PDF]

Sci Rep, 2019
Sundaramoorthy NS, Suresh P, Selva Ganesan S, GaneshPrasad A, Nagarajan S.   +4 more
europepmc   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Efflux pump inhibitor chlorpromazine effectively increases the susceptibility of <i>Escherichia coli</i> to antimicrobial peptide Brevinin-2CE. [PDF]

Future Microbiol
Bing C, Mengjuan A, Xinyu M, Chixin Z, Xinyao T, Yan S, Zhi L.   +6 more
europepmc   +1 more source