British Journal of Clinical Pharmacology, EarlyView.Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh +5 more
wiley +1 more source
Biomaterial design strategies for enhancing mitochondrial transplantation therapy
BMEMat, EarlyView.Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang +12 more
wiley +1 more source
BMEMat, EarlyView.A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie +12 more
wiley +1 more source
Zinc sulfate acts as an efflux pump inhibitor on Pseudomonas aeruginosa clinical isolates. [PDF]
World J Microbiol BiotechnolAbdelraheem WM +3 more
europepmc +1 more source
Determination of imipenem efflux-mediated resistance in Acinetobacter spp., using an efflux pump inhibitor. [PDF]
Iran J Microbiol, 2019 Amiri G +5 more
europepmc +1 more source
A Core Head, Neck, and Neuroanatomy Syllabus for Physical Therapy Student Education
Clinical Anatomy, EarlyView.ABSTRACT Head, neck, and neuroanatomy are essential components of physical therapy education due to their broad clinical applications. Detailed syllabi exist for medical students, yet none have been developed for physical therapy. This study aimed to produce an International Federation of Associations of Anatomists core head, neck, and neuroanatomy ...
Stephanie J. Woodley +4 more
wiley +1 more source
Synergistic effect of the hybrid compounds of cationic pillararene and an efflux pump inhibitor against Gram-negative bacteria. [PDF]
RSC Med ChemLiu Y, Wu G, Zhu J, Jiang Y, Liu H.
europepmc +1 more source
Coal‐Based Anthraquinone Synthesized by Cascade Catalytic Hydrogenation and Oxidation
Carbon and Hydrogen, EarlyView.A cascade catalytic process has been proposed for the conversion of AN into the valuable AQ, utilizing a Pt/6MoOx/Al2O3 catalyst for hydrogenation to DHA and a RuOx‐Ce0.7Zr0.3O2 catalyst for oxidation, thus presenting an efficient route from coal to high‐value chemicals.
Jiuqiang Ma +5 more
wiley +1 more source
PANTAX: a phase Ib clinical trial of the efflux pump inhibitor SCO-101 in combination with gemcitabine and nab-paclitaxel in non-resectable or metastatic pancreatic cancer. [PDF]
Invest New DrugsShim S +15 more
europepmc +1 more source
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Background Advanced heart failure (HF) remains a clinical challenge, and mitral transcatheter edge‐to‐edge repair (M‐TEER) has emerged as a potential bridging strategy. Aims To describe the clinical outcomes of M‐TEER in a single‐center cohort of patients with advanced HF and to identify anatomical and clinical features potentially associated ...
Pedro Castilhos de Freitas Crivelaro +8 more
wiley +1 more source