Results 281 to 290 of about 59,328 (312)
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Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor
Expert Review of Anticancer Therapy, 2007P-glycoprotein actively transports structurally unrelated compounds out of cells, conferring the multidrug resistance phenotype in cancer. Tariquidar is a potent, specific, noncompetitive inhibitor of P-glycoprotein. Tariquidar inhibits the ATPase activity of P-glycoprotein, suggesting that the modulating effect is derived from the inhibition of ...
Elizabeth, Fox, Susan E, Bates
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Multidrug Efflux Pumps Attenuate the Effect of MGMT Inhibitors
Molecular Pharmaceutics, 2015Various mechanisms of drug resistance attenuate the effectiveness of cancer therapeutics, including drug transport and DNA repair. The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) is a key factor determining the resistance against alkylating anticancer drugs inducing the genotoxic DNA lesions O(6)-methylguanine and O(6 ...
Karl-Heinz, Tomaszowski +2 more
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Substituted dihydronaphthalenes as efflux pump inhibitors of Staphylococcus aureus
European Journal of Medicinal Chemistry, 2010A new series of 3-(substituted-3,4-dihydronaphthyl)-2-propenoic acid amides has been prepared through convergent synthetic strategies and tested in combination with ciprofloxacin against NorA overexpressing Staphylococcus aureus 1199B as test strain for potentiating of the drug activity.
Thota, Niranjan +7 more
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Efflux pump inhibitors of clinically relevant multidrug resistant bacteria
Medicinal Research Reviews, 2019AbstractBacterial infections are an increasingly serious issue worldwide. The inability of existing therapies to treat multidrug‐resistant pathogens has been recognized as an important challenge of the 21st century. Efflux pumps are important in both intrinsic and acquired bacterial resistance and identification of small molecule efflux pump inhibitors
Andraž Lamut +3 more
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Current Microbiology, 2009
In gram negative bacteria, fluoroquinolone resistance is acquired by target mutations in topoisomerase genes or by reducing the permeation of drugs due to the increase in expression of endogenous multidrug efflux pumps that expel structurally unrelated antimicrobial agents.
Abolghasem, Tohidpour +3 more
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In gram negative bacteria, fluoroquinolone resistance is acquired by target mutations in topoisomerase genes or by reducing the permeation of drugs due to the increase in expression of endogenous multidrug efflux pumps that expel structurally unrelated antimicrobial agents.
Abolghasem, Tohidpour +3 more
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Tackling multi-drug resistant fungi by efflux pump inhibitors
Biochemical PharmacologyThe emergence of multidrug-resistant fungi is of grave concern, and its infections are responsible for significant deaths among immunocompromised patients. The treatment of fungal infections primarily relies on a clinical class of antibiotics, including azoles, polyenes, echinocandins, polyketides, and a nucleotide analogue.
Kritika Engle, Gautam Kumar
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Polymeric Efflux Pump Inhibitors in Oral Drug Delivery
American Journal of Drug Delivery, 2006Drug efflux pump transporters of the ATP-binding cassette family such as P-glycoprotein and multidrug resistance proteins 1 and 2 are believed to confer multidrug resistance to tumor cells and affect overall absorption, distribution, metabolism, and elimination of orally administered clinically important therapeutic substances.
Andreas Bernkop-Schn??rch +1 more
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Microbial Efflux of Antibiotics and Inhibitors of Efflux Pumps
2014Detergent-like bile salts kill bacterial cells by destroying bacterial multidrug resistance (MDR) efflux systems. These not only play an important role in antibacterial resistance but also contribute to bacterial pathogenesis. Reserpine and H+/K+ ATPase inhibitors can significantly reduce MICs, increase killing activity, and prolong the postantibiotic ...
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ปั๊มขับยาปฏิชีวนะและสารยับยั้ง Antibiotic Efflux Pumps and Inhibitors
มค.-ธค., 2, ไทยไภษัชยนิพนธ์openaire +1 more source
Natural Product as Efflux Pump Inhibitors Against MRSA Efflux Pumps: An Update
2022Pallavi Ahirrao +2 more
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