Results 151 to 160 of about 54,733 (297)

Targeting the Mapk13‐Tcf1‐Slc7a5 Axis via One‐Carbon Metabolic Regulation to Prevent Chronic Allograft Vasculopathy

Advanced Science, EarlyView.
This study emphasizes the role of the Mapk13‐Tcf1‐Slc7a5‐methionine metabolism axis in stem‐like CD4+ T cells. Moreover, it uncovers the mechanism through which limiting one‐carbon metabolism in CD4+ stem‐like T cells suppresses the tide of chronic allograft vasculopathy, offering potential targets to promote long‐term graft survival.
Wang Yi, Di Wu, Jing Liu, Shi Chen, Liu Song, Bin Xie, Aini Xie, Peixiang Lan, Zhishui Chen   +8 more
wiley   +1 more source

Evaluation of ellagic acid and gallic acid as efflux pump inhibitors in strains of Staphylococcus aureus. [PDF]

Biol Open, 2022
Macêdo NS, Barbosa CRDS, Bezerra AH, Silveira ZS, da Silva L, Coutinho HDM, Dashti S, Kim B, da Cunha FAB, da Silva MV.   +9 more
europepmc   +1 more source

Broad blocking of MDR efux pumps by acetylshikonin and acetoxyisovalerylshikonin to generate hypersensitive phenotype of malignant carcinoma cells [PDF]

, 2018
Cytotoxic activities of acetylshikonin and acetoxyisovalerylshikonin alone and in combination with chemotherapeutic agents against parental and drug resistant cell lines were determined using the MTT assay.
Aliakbari, Fatemeh., Azadfallah, Elahe., Elahian, Fatemeh., Ghiasi Tabari, Parmida., Mirzaei, Seyed Abbas., Reiisi, Somayeh., Shekari, Abolfazl.   +6 more
core  

A Cascade Recognition of Activatable Probe for Fluorescence Navigation Glioblastoma Surgery: Overcoming Blood‐Brain Barrier and Off‐Target Limitations

Advanced Science, EarlyView.
A cascade recognition of activatable probe ANG‐hCy‐MC is used for high‐precision depiction of glioblastoma (GBM) margin. This probe crosses the blood‐brain barrier (BBB) through LRP1 receptor‐mediated transport and provides excellent fluorescence signal contrast between the tumor and normal tissues, thereby enabling ultra‐selective imaging and precise ...
Xinru An, Yu Guo, Yongning Bian, Yanli Tan, Chuan Fang, Hengzhu Zhang, Xueqian Chen, Lin Yuan, Dongdong Su   +8 more
wiley   +1 more source

Derivatives of Trimethoxybenzoic Acid and Gallic Acid as Potential Efflux Pump Inhibitors: In Silico and In Vitro Studies. [PDF]

Int J Mol Sci, 2022
Neves AR, Durães F, Freitas-Silva J, Szemerédi N, Martins-da-Costa P, Pinto E, Correia-da-Silva M, Spengler G, Sousa E.   +8 more
europepmc   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy

Hepatology, EarlyView., 2022
Serum bile acid levels predict outcomes in patients with biliary atresia who achieve normalized bilirubin levels after Kasai portoenterostomy. Abstract Background and Aims In biliary atresia, serum bilirubin is commonly used to predict outcomes after Kasai portoenterostomy (KP).
Sanjiv Harpavat, Kieran Hawthorne, Kenneth D. R. Setchell, Monica Narvaez Rivas, Lisa Henn, Charlotte A. Beil, Saul J. Karpen, Vicky L. Ng, Estella M. Alonso, Jorge A. Bezerra, Stephen L. Guthery, Simon Horslen, Kathy M. Loomes, Patrick McKiernan, John C. Magee, Robert M. Merion, Jean P. Molleston, Philip Rosenthal, Richard J. Thompson, Kasper S. Wang, Ronald J. Sokol, Benjamin L. Shneider, for Childhood Liver Disease Research Network (ChiLDReN)   +22 more
wiley   +1 more source

Evaluating the ciprofloxacin potentiation efficacy of repurposed drug flupentixol through efflux pump inhibition of pathogenic bacteria

Scientific Reports
Antimicrobial resistance concerning burdens is increasing day by day. Efflux pump upregulation is one of the mechanisms through which bacteria develop resistance to antibiotics.
Md. Momin-Reza, Rafat Hossain Rafi, Rukunuzzaman Mia, Md. Jonaid Tawfiq, Md. Rafiqul Islam Khan, Md. Omar Faruqe, Sitelbanat Yassin Ehaimir, Md. Abdul Alim Al-Bari   +7 more
doaj   +1 more source

Plant Secondary Metabolites on Efflux-Mediated Antibiotic Resistant Stenotrophomonas Maltophilia: Potential of Herbal-Derived Efflux Pump Inhibitors. [PDF]

Antibiotics (Basel), 2023
Nguyen THT, Nguyen NAT, Nguyen HD, Nguyen TTH, Le MH, Pham MQ, Do HN, Hoang KC, Michalet S, Dijoux-Franca MG, Pham HN.   +10 more
europepmc   +1 more source

Electrochemical Nitrate Reduction Reaction to Ammonia at Industrial‐Level Current Densities

Advanced Science, EarlyView.
This review starts from the mechanism and theoretical basis of electrochemical nitrate reduction reaction (NO3−RR), and systematically summarizes and discusses the design strategies of industrial‐level current density catalysts. In addition, the progress of industrial‐level NO3−RR‐based electrolyzers, including flow reactor and membrane electrode ...
Zhijie Cui, Honghai Wang, Chunli Li, Wenchao Peng, Jiapeng Liu   +4 more
wiley   +1 more source