Results 251 to 260 of about 54,728 (292)

Detecting Antibiotic Resistance in Strains of Selected Gram‐Negative Bacterial Species Using Raman Spectroscopy

Journal of Raman Spectroscopy, EarlyView.
Raman spectroscopy successfully identified antibiotic‐resistant Gram‐negative strains. Resistant strains of four bacterial species were discriminated from sensitive ones with 99.1% accuracy using PLS regression. The method allows for rapid, label‐free detection of antibiotic resistance.
Fernanda Sant Ana de Siqueira e Oliveira, Adriano Moraes da Silva, Marcos Tadeu T. Pacheco, Landulfo Silveira Jr.   +3 more
wiley   +1 more source

Microbial communities and functional diversity in seafood

JSFA reports, EarlyView.
Abstract Functional diversity encompasses ecosystem processes that enhance adaptability to environmental change. This study explores the diversity of microorganisms associated with seafood. In this paper, we present our knowledge of microbial diversity in relation to seafood.
Christian Larbi Ayisi, Samuel Ayeh Osei, Grace Afumwaa Boamah, Gertrude Dzifa Mensah   +3 more
wiley   +1 more source

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Efflux pump inhibitors of clinically relevant multidrug resistant bacteria

Medicinal Research Reviews, 2019
AbstractBacterial infections are an increasingly serious issue worldwide. The inability of existing therapies to treat multidrug‐resistant pathogens has been recognized as an important challenge of the 21st century. Efflux pumps are important in both intrinsic and acquired bacterial resistance and identification of small molecule efflux pump inhibitors
Andraž Lamut, Lucija Peterlin Mašič, Danijel Kikelj, Tihomir Tomašič   +3 more
openaire   +4 more sources

Efflux pump inhibitors: new updates

Pharmacological Reports, 2020
The discovery of antibiotics ought to have ended the issue of bacterial infections, but this was not the case as it has led to the evolution of various mechanisms of bacterial resistance against various antibiotics. The efflux pump remains one of the mechanisms through which organisms develop resistance against antibiotics; this is because organisms ...
Manaf AlMatar, Osman Albarri, Essam A. Makky, Fatih Köksal   +3 more
openaire   +2 more sources

New-generation efflux pump inhibitors

Expert Review of Clinical Pharmacology, 2008
The development of novel efflux pump inhibitors is an emerging and challenging research field. Besides the use of such excipients in cancer therapy, efflux pump inhibitors are gaining increasing interest with regards to drug delivery. In particular, inhibition of efflux pumps located in the intestine and the blood-brain barrier offers promising ...
Martin, Werle, Hirofumi, Takeuchi, Andreas, Bernkop-Schnürch   +2 more
openaire   +2 more sources

Efflux pump inhibitors in bacteria

Expert Opinion on Therapeutic Patents, 2007
The efficacy of antibiotherapy of infectious diseases is strongly compromised by the advent and spread of antibiotic resistance. Active efflux of cytotoxic drugs mediated by multi-drug transporters is the basis of multi-drug resistance in prokaryotic cells.
Sandrine Alibert, Jean-Marie Pagès
openaire   +1 more source

Computational modelling of efflux pumps and their inhibitors [PDF]

Essays in Biochemistry, 2017
Antimicrobial resistance is based on the multifarious strategies that bacteria adopt to face antibiotic therapies, making it a key public health concern of our era. Among these strategies, efflux pumps (EPs) contribute significantly to increase the levels and profiles of resistance by expelling a broad range of unrelated compounds – buying time for the
RAMASWAMY, VENKATA KRISHNAN, CACCIOTTO, PIERPAOLO, MALLOCI, GIULIANO, VARGIU, ATTILIO VITTORIO, RUGGERONE, PAOLO   +4 more
openaire   +2 more sources

Bacterial Efflux Pump Inhibitors

2008
Infections caused by multidrug-resistant Gram-negative pathogens play a major role in the morbidity and mortality of hospitalized patients. The rise of resistance to current antibiotic therapies has made the discovery of new agents urgent. One of the major antibiotic resistance mechanisms utilized by more than 15 species of Gram-negative bacterial ...
Barbara J, Kamicker, Michael T, Sweeney, Frank, Kaczmarek, Fadia, Dib-Hajj, Wenchi, Shang, Kim, Crimin, Joan, Duignan, Thomas D, Gootz   +7 more
openaire   +2 more sources

Bacterial efflux systems and efflux pumps inhibitors

Biochimie, 2005
It is now well established that bacterial resistance to antibiotics has become a serious problem of public health that concerns almost all antibacterial agents and that manifests in all fields of their application. Among the three main mechanisms involved in bacterial resistance (target modification, antibiotic inactivation or default of its ...
openaire   +2 more sources

An Overview of Bacterial Efflux Pumps and Computational Approaches to Study Efflux Pump Inhibitors

Future Medicinal Chemistry, 2016
Micro-organisms express a wide range of transmembrane pumps known as multidrug efflux pumps that improve the micro-organism's ability to survive in severe environments and contribute to resistance against antibiotic and antimicrobial agents. There is significant interest in developing efflux inhibitors as an adjunct to treatment with current and next ...
Jamshidi, Shirin, Sutton, Mark, Rahman, Khondaker Mirazur   +2 more
openaire   +3 more sources