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Current Microbiology, 2009
In gram negative bacteria, fluoroquinolone resistance is acquired by target mutations in topoisomerase genes or by reducing the permeation of drugs due to the increase in expression of endogenous multidrug efflux pumps that expel structurally unrelated antimicrobial agents.
Abolghasem, Tohidpour +3 more
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In gram negative bacteria, fluoroquinolone resistance is acquired by target mutations in topoisomerase genes or by reducing the permeation of drugs due to the increase in expression of endogenous multidrug efflux pumps that expel structurally unrelated antimicrobial agents.
Abolghasem, Tohidpour +3 more
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Tackling multi-drug resistant fungi by efflux pump inhibitors
Biochemical PharmacologyThe emergence of multidrug-resistant fungi is of grave concern, and its infections are responsible for significant deaths among immunocompromised patients. The treatment of fungal infections primarily relies on a clinical class of antibiotics, including azoles, polyenes, echinocandins, polyketides, and a nucleotide analogue.
Kritika Engle, Gautam Kumar
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Polymeric Efflux Pump Inhibitors in Oral Drug Delivery
American Journal of Drug Delivery, 2006Drug efflux pump transporters of the ATP-binding cassette family such as P-glycoprotein and multidrug resistance proteins 1 and 2 are believed to confer multidrug resistance to tumor cells and affect overall absorption, distribution, metabolism, and elimination of orally administered clinically important therapeutic substances.
Andreas Bernkop-Schn??rch +1 more
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Microbial Efflux of Antibiotics and Inhibitors of Efflux Pumps
2014Detergent-like bile salts kill bacterial cells by destroying bacterial multidrug resistance (MDR) efflux systems. These not only play an important role in antibacterial resistance but also contribute to bacterial pathogenesis. Reserpine and H+/K+ ATPase inhibitors can significantly reduce MICs, increase killing activity, and prolong the postantibiotic ...
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ปั๊มขับยาปฏิชีวนะและสารยับยั้ง Antibiotic Efflux Pumps and Inhibitors
มค.-ธค., 2, ไทยไภษัชยนิพนธ์openaire +1 more source
Natural Product as Efflux Pump Inhibitors Against MRSA Efflux Pumps: An Update
2022Pallavi Ahirrao +2 more
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Bacterial Drug Efflux Pump Inhibitors from Plants
2022Armel Jackson Seukep +8 more
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