Using cellular fitness to map the structure and function of a major facilitator superfamily effluxer. [PDF]
, 2017 The major facilitator superfamily (MFS) effluxers are prominent mediators of antimicrobial resistance. The biochemical characterization of MFS proteins is hindered by their complex membrane environment that makes in vitro biochemical analysis challenging.
Bennett, Matthew R +5 more
core +2 more sources
Synthesis of Berberine—Efflux Pump Inhibitor Hybrid Antibacterials [PDF]
Synthetic Communications, 2010 This paper reports the compact synthesis of two isomeric dual-action hybrid antimicrobials where the 13-position of the antibacterial berberine has been linked via 3'- and 4'-methylene bridges to INF55 (5-nitro-2-phenylindole), an inhibitor of the bacterial NorA multidrug-resistance pump.
Bremner, J. B., Kelso, Michael J
openaire +3 more sources
RND-type Drug Efflux Pumps from Gram-negative bacteria: Molecular Mechanism and Inhibition
Frontiers in Microbiology, 2015 Drug efflux protein complexes confer multidrug resistance on bacteria by transporting a wide spectrum of structurally diverse antibiotics. Moreover, organisms can only acquire resistance in the presence of an active efflux pump.
Henrietta eVenter +3 more
doaj +1 more source
Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions [PDF]
, 2014 Antimicrobials targeting cell wall biosynthesis are generally considered inactive against nonreplicating bacteria. Paradoxically, we found that under nonpermissive growth conditions, exposure of Mycobacterium bovis BCG bacilli to such antimicrobials ...
Andrew, Peter W +12 more
core +2 more sources
Antibiotics, 2023 Pseudomonas aeruginosa is a significant pathogen identified with healthcare-associated infections. The present study evaluates the role of biofilm and efflux pump activities in influencing high-level resistance in virulent P.
Paul A. Akinduti +11 more
doaj +1 more source
Mechanism Underlying the Reversal of Drug Resistance in P-Glycoprotein-Expressing Leukemia Cells by Pinoresinol and the Study of a Derivative [PDF]
, 2017 P-glycoprotein (P-gp) is a membrane protein associated with multidrug resistance (MDR) due to its key role in mediating the traffic of chemotherapeutic drugs outside cancer cells, leading to a cellular response that hinders efforts toward successful ...
Carpinella, Maria Cecilia +10 more
core +2 more sources
Evaluation of the Blue-Carba test for rapid detection of carbapenemases in gram-negative Bacilli [PDF]
, 2015 The Blue-Carba test (BCT) is a biochemical test for rapid (2 h)detection of carbapenemase production in Gram-negative bacillidirectly from bacterial culture .
Albornoz, Ezequiel Pablo +7 more
core +1 more source
Efflux pump inhibitors: targeting mycobacterial efflux systems to enhance TB therapy [PDF]
Journal of Antimicrobial Chemotherapy, 2015 The emergence of drug resistance continues to plague TB control, with a global increase in the prevalence of MDR-TB. This acts as a gateway to XDR-TB and thus emphasizes the urgency for drug development and optimal treatment options. Bedaquiline is the first new anti-TB drug approved by the FDA in 40 years and has been shown to be an effective ...
Caroline M, Pule +6 more
openaire +2 more sources
Open Veterinary Journal, 2023 Background: Antibiotic resistant pathogens became a real global threat for human and animal health. This needs to concentrate the efforts to minimise and control these organisms.
Dhama Alsallami +3 more
doaj +1 more source
Dynamic energy budget approach to evaluate antibiotic effects on biofilms [PDF]
, 2017 Quantifying the action of antibiotics on biofilms is essential to devise therapies against chronic infections. Biofilms are bacterial communities attached to moist surfaces, sheltered from external aggressions by a polymeric matrix.
Birnir, Bjorn +3 more
core +3 more sources