Results 51 to 60 of about 54,733 (297)

Management of imatinib-resistant CML patients [PDF]

, 2007
Imatinib has had marked impact on outcomes in chronic myelogenous leukemia (CML) patients for all stages of the disease and is endorsed by international treatment guidelines as the first line option.
Branford S, Burger H, Burgess MR, Cortes J, Crossman LC, Donato NJ, Druker BJ, Gambacorti-Passerini C, Giles F, Hochhaus A, Hughes TP, Iacobucci I, Kantarjian H, Lahaye T, Mahon FX, Melo JV, O'Hare T, Quintas-Cardama A, Rousselot P, Sleijfer S, Soverini S, Weisberg E   +21 more
core   +1 more source

Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2012
Multidrug resistant (MDR) tuberculosis is caused by Mycobacterium tuberculosis resistant to isoniazid and rifampicin, the two most effective drugs used in tuberculosis therapy.
Diana Machado, Isabel Couto, João Perdigão, Liliana Rodrigues, Isabel Portugal, Pedro Baptista, Bruno Veigas, Leonard Amaral, Miguel Viveiros   +8 more
doaj   +1 more source

New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in Bacteria [PDF]

, 2017
Multidrug resistance (MDR) has appeared in response to selective pressures resulting from the incorrect use of antibiotics and other antimicrobials.
Amaral, Leonard, Gajdács, Márió, Kincses, Annamária, Spengler, Gabriella   +3 more
core   +2 more sources

The 1,8-naphthyridines sulfonamides are NorA efflux pump inhibitors

Journal of Global Antimicrobial Resistance, 2021
Efflux pumps are transmembrane proteins associated with bacterial resistance mechanisms. Bacteria use these proteins to actively transport antibiotics to the extracellular medium, preventing the pharmacological action of these drugs. This study aimed to evaluate in vitro the antibacterial activity of 1,8-naphthyridines sulfonamides, as well as their ...
Cícera Datiane de Morais Oliveira-Tintino, Débora Feitosa Muniz, Cristina Rodrigues dos Santos Barbosa, Raimundo Luiz Silva Pereira, Iêda Maria Begnini, Ricardo Andrade Rebelo, Luiz Everson da Silva, Sandro Lucio Mireski, Michele Caroline Nasato, Maria Isabel Lacowicz Krautler, Pedro Silvino Pereira, José Galberto Martins da Costa, Fabiola Fernandes Galvão Rodrigues, Alexandre Magno Rodrigues Teixeira, Jaime Ribeiro-Filho, Saulo Relison Tintino, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Teresinha Gonçalves da Silva   +18 more
openaire   +3 more sources

Enhanced Efficacy of Ciprofloxacin and Tobramycin against Staphylococcus aureus When Combined with Corydalis Tuber and Berberine through Efflux Pump Inhibition

Antibiotics
One way that bacteria develop antibiotic resistance is by reducing intracellular antibiotic concentrations through efflux pumps. Therefore, enhancing the efficacy of antibiotics using efflux pump inhibitors provides a way to overcome this type of ...
Yena Seo, Minjun Kim, Tae-Jong Kim
doaj   +1 more source

Prevalence of QoI resistance and mtDNA diversity in the Irish Zymoseptoria tritici population [PDF]

, 2019
peer-reviewedThe emergence and spread of Quinone outside Inhibitor (QoI) fungicide resistance in the Irish Zymoseptoria tritici population in the early 2000s had immediate impacts on the efficacy of the entire group of fungicides for the control of ...
Bucar, D.E., Hutton, F., Kildea, Steven, Phelan, S., Rosa, S. de la, Welch, T.E.   +5 more
core   +1 more source

Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates

Frontiers in Microbiology
Antibiotic-resistant Gram-negative bacteria are an increasing threat to human health. Strategies to restore antibiotic efficacy include targeting multidrug efflux pumps by competitive efflux pump inhibitors. These could be derived from natural substrates
Léna Mazza, Léna Mazza, Alexandre Bory, Alexandre Bory, Alexandre Luscher, Alexandre Luscher, Joachim Kloehn, Jean-Luc Wolfender, Jean-Luc Wolfender, Christian van Delden, Christian van Delden, Thilo Köhler, Thilo Köhler   +12 more
doaj   +1 more source

Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice [PDF]

, 2017
Introduction : Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development.
De Lombaerde, Stef, De Vos, Filip, Devisscher, Lindsey, Kersemans, Ken, Neyt, Sara, Van Vlierberghe, Hans, Vanhove, Christian, Verhoeven, Jeroen   +7 more
core   +3 more sources

Ethidium bromide transport across Mycobacterium smegmatis cell-wall: correlation with antibiotic resistance

BMC Microbiology, 2011
Background Active efflux systems and reduced cell-wall permeability are considered to be the main causes of mycobacterial intrinsic resistance to many antimicrobials.
Couto Isabel, Ramos Jorge, Rodrigues Liliana, Amaral Leonard, Viveiros Miguel   +4 more
doaj   +1 more source

Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli [PDF]

PeerJ, 2017
Efflux pump inhibitors are of great interest since their use as adjuvants of bacterial chemotherapy can increase the intracellular concentrations of the antibiotics and assist in the battle against the rising of antibiotic-resistant bacteria.
Diana Machado, Laura Fernandes, Sofia S. Costa, Rolando Cannalire, Giuseppe Manfroni, Oriana Tabarrini, Isabel Couto, Stefano Sabatini, Miguel Viveiros   +8 more
doaj   +2 more sources