Open Veterinary Journal, 2023 Background: Antibiotic resistant pathogens became a real global threat for human and animal health. This needs to concentrate the efforts to minimise and control these organisms.
Dhama Alsallami +3 more
doaj +1 more source
Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors [PDF]
, 2014 Efflux pumps of the resistance nodulation division (RND) superfamily, such as AcrB, make a major contribution to multidrug resistance in Gram-negative bacteria. The development of inhibitors of the RND pumps would improve the efficacy of current and next-
Nguyen, ST +4 more
core +2 more sources
Journal of Infection in Developing Countries, 2023 Introduction: Enterococcus faecium is a major cause of community and hospital-acquired infections. Due to limited options for infection with fluoroquinolones-resistant Enterococci, novel therapeutics are urgently needed.
Mehdi Mirzaii +7 more
doaj +1 more source
Using cellular fitness to map the structure and function of a major facilitator superfamily effluxer. [PDF]
, 2017 The major facilitator superfamily (MFS) effluxers are prominent mediators of antimicrobial resistance. The biochemical characterization of MFS proteins is hindered by their complex membrane environment that makes in vitro biochemical analysis challenging.
Bennett, Matthew R +5 more
core +2 more sources
Journal of Infection in Developing Countries, 2016 Introduction: Multidrug resistance in Pseudomonas aeruginosa may be due to efflux pump overexpression. This study phenotypically examined the role of efflux pump inhibitors in decreasing antibiotic cross-resistance between beta-lactams, fluoroquinolones,
Mahshid Talebi-Taher +4 more
doaj +1 more source
Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2012 Multidrug resistant (MDR) tuberculosis is caused by Mycobacterium tuberculosis resistant to isoniazid and rifampicin, the two most effective drugs used in tuberculosis therapy.
Diana Machado +8 more
doaj +1 more source
Dynamic energy budget approach to evaluate antibiotic effects on biofilms [PDF]
, 2017 Quantifying the action of antibiotics on biofilms is essential to devise therapies against chronic infections. Biofilms are bacterial communities attached to moist surfaces, sheltered from external aggressions by a polymeric matrix.
Birnir, Bjorn +3 more
core +3 more sources
Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against gram-positive pathogenic bacteria. [PDF]
PLoS ONE, 2011 BACKGROUND:Traditional antibiotics are increasingly suffering from the emergence of multidrug resistance amongst pathogenic bacteria leading to a range of novel approaches to control microbial infections being investigated as potential alternative ...
Yiannis C Fiamegos +8 more
doaj +1 more source
Mechanism Underlying the Reversal of Drug Resistance in P-Glycoprotein-Expressing Leukemia Cells by Pinoresinol and the Study of a Derivative [PDF]
, 2017 P-glycoprotein (P-gp) is a membrane protein associated with multidrug resistance (MDR) due to its key role in mediating the traffic of chemotherapeutic drugs outside cancer cells, leading to a cellular response that hinders efforts toward successful ...
Carpinella, Maria Cecilia +10 more
core +2 more sources
The 1,8-naphthyridines sulfonamides are NorA efflux pump inhibitors
Journal of Global Antimicrobial Resistance, 2021 Efflux pumps are transmembrane proteins associated with bacterial resistance mechanisms. Bacteria use these proteins to actively transport antibiotics to the extracellular medium, preventing the pharmacological action of these drugs. This study aimed to evaluate in vitro the antibacterial activity of 1,8-naphthyridines sulfonamides, as well as their ...
Cícera Datiane de Morais Oliveira-Tintino +18 more
openaire +3 more sources