Results 91 to 100 of about 54,202 (287)

Functional analysis and NMR studies of multi-drug efflux pumps

Efflux pumps play an important role in bacterial multi-drug resistance by actively expelling antibiotics and toxic compounds from the cell. We describe an integrated workflow for the characterisation of inner membrane efflux pumps, consisting of an in ...
Bonev, Boyan B., Goode, Alice, Ralph, Dominic, Blair, Jessica M.A., Yeh, Vivien, Williams, Paul   +5 more
core   +2 more sources

Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii

, 2018
Antibiotic-resistant Acinetobacter baumannii causes infections that are extremely difficult to treat. A significant role in these resistance profiles is attributed to multidrug efflux pumps, especially those belonging to the ...
Jon W. Weeks, Inga V. Leus, Helen I. Zgurskaya, Vincent Bonifay, Lauren Smith, Sophie Richardson   +5 more
core   +1 more source

Multidrug efflux pumps in Staphylococcus aureus: an update. [PDF]

, 2013
The emergence of infections caused by multi- or pan-resistant bacteria in the hospital or in the community settings is an increasing health concern. Albeit there is no single resistance mechanism behind multiresistance, multidrug efflux pumps, proteins ...
Couto, Isabel Maria dos Santos Leitão, Amaral, Leonard, Bettencourt, Miguel Viveiros, Costa, SS   +3 more
core   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Synthetic feedback loop model for increasing microbial biofuel production using a biosensor

Frontiers in Microbiology, 2012
Current biofuel production methods use engineered bacteria to break down cellulose and convert it to biofuel. A major challenge in microbial fuel production is that increasing biofuel yields can be limited by the toxicity of the biofuel to the organism ...
Mary eHarrison, Mary eDunlop
doaj   +1 more source

Overproduction of efflux pumps caused reduced susceptibility to carbapenem under consecutive imipenem-selected stress in Acinetobacter baumannii

, 2018
Yanpeng Zhang,1,2 Zhuocheng Li,2 Xiaolong He,1 Fanglin Ding,2 Weiqing Wu,2 Yong Luo,2 Bing Fan,2 Hong Cao1 1Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University,
Ding F, Li Z, Cao H, Zhang Y, He X, Luo Y, Wu W, Fan B   +7 more
core  

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Is the efflux pump inhibitor Verapamil a potential booster for isoniazid against Mycobacterium tuberculosis?

Brazilian Journal of Pharmaceutical Sciences, 2020
The membrane-based efflux pump systems are recognized to have an important role in pathogenicity and drug resistance in Mycobacterium tuberculosis by the extrusion of toxic substrates and drugs from the inner bacillus. This study aimed to investigate the
Renata Claro Ribeiro do Amaral, Katiany Rizzieri Caleffi-Ferracioli, Fernanda de Oliveira Demitto, Aryadne Larissa de Almeida, Vera Lucia Dias Siqueira, Regiane Bertin de Lima Scodro, Clarice Queico Fujimura Leite, Fernando Rogério Pavan, Rosilene Fressatti Cardoso   +8 more
doaj   +1 more source

Mycobacterium tuberculosis efflux pumps: an update

, 2013
The selection and diffusion of Mycobacterium tuberculosis multidrug-resistant (MDR-TB), extensively drug-resistant (XDR-TB) and, more recently, totally drug-resistant (TDR) strains constitute a serious threat for tuberculosis global control. Mycobacteria,
PASCA, MARIA ROSALIA, BURONI, SILVIA, RICCARDI, GIOVANNA   +2 more
core  

Crystal Facet‐Polysaccharide Matching in CFS‐P Nanocrystals Drives Fungal Uptake, Vacuole Destruction, and Selective Antifungal Activity

Advanced Science, EarlyView.
Facet‐engineered PVP‐capped CuFeSe2 nanocrystals exhibit potent, selective antifungal activity by strongly binding cell‐wall mannan, enabling vacuolar entry and organelle disruption. High‐index facets show superior mannan affinity, validated by theoretical calculations and experiments. CFS‐P induces vacuolar cavitation, mitochondrial abnormalities, and
Zhaohui Wang, Xiaojin Deng, Xujuan Huang, Yuhang Pan, Yao Qin, Lu Zhang, Le Xu, Tianyi Qin, Deteng Zhang, Yi Ma, Yalong Wang   +10 more
wiley   +1 more source