Results 221 to 230 of about 985,633 (279)
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Microbial Pathogenesis, 2021
Acinetobacter baumannii is an ESKAPE pathogen known to cause fatal nosocomial infections. With the surge of multidrug resistance (MDR) in the bacterial system, effective treatment measures have become very limited. The MDR in A.
Monalisa Tiwari, Vishvanath Tiwari
exaly +2 more sources
Acinetobacter baumannii is an ESKAPE pathogen known to cause fatal nosocomial infections. With the surge of multidrug resistance (MDR) in the bacterial system, effective treatment measures have become very limited. The MDR in A.
Monalisa Tiwari, Vishvanath Tiwari
exaly +2 more sources
Leishmaniasis: efflux pumps and chemoresistance
International Journal of Antimicrobial Agents, 2003Resistance of parasitic protozoa such as Leishmania to therapeutic drugs continues to escalate in developing countries. Treatment programs for human leishmaniasis are still based on pentavalent antimonials but resistance to these compounds has been a persistent problem.
Clara Leandro, Lenea Campino
exaly +3 more sources
Mycobacterial efflux pumps and chemotherapeutic implications
International Journal of Antimicrobial Agents, 2003The demonstration of the existence of active efflux pumps in mycobacteria raises the question of whether or not these can increase in number and activity rendering wild-type mycobacteria increasingly resistant to a given antibiotic. This could be a mechanism by which mutated resistant strains become better fit to the selective environment ...
MIGUEL Viveiros +2 more
exaly +3 more sources
Multidrug efflux pumps: structure, function and regulation
Nature Reviews Microbiology, 2018Klaas Pos, Dijun Du, Xuan Wang-Kan
exaly +2 more sources
Microbial Pathogenesis, 2021
Resistance-Nodulation-Division (RND) efflux pumps are responsible for multidrug resistance in Pseudomonas aeruginosa. The present study aimed to evaluate the overexpression of RND efflux pumps and its role in the antibiotic resistance of P.
Abed Zahedi bialvaei +5 more
semanticscholar +1 more source
Resistance-Nodulation-Division (RND) efflux pumps are responsible for multidrug resistance in Pseudomonas aeruginosa. The present study aimed to evaluate the overexpression of RND efflux pumps and its role in the antibiotic resistance of P.
Abed Zahedi bialvaei +5 more
semanticscholar +1 more source
Biochemical Pharmacology, 2000
Active efflux from procaryotic as well as eucaryotic cells strongly modulates the activity of a large number of antibiotics. Effective antibiotic transport has now been observed for many classes of drug efflux pumps. Thus, within the group of primary active transporters, predominant in eucaryotes, six families belonging to the ATP-binding cassette ...
F, Van Bambeke, E, Balzi, P M, Tulkens
openaire +2 more sources
Active efflux from procaryotic as well as eucaryotic cells strongly modulates the activity of a large number of antibiotics. Effective antibiotic transport has now been observed for many classes of drug efflux pumps. Thus, within the group of primary active transporters, predominant in eucaryotes, six families belonging to the ATP-binding cassette ...
F, Van Bambeke, E, Balzi, P M, Tulkens
openaire +2 more sources
Efflux pumps in Mycobacterium tuberculosis and their inhibition to tackle antimicrobial resistance.
Trends in Microbiology, 2021Tuberculosis (TB), an infectious disease caused by the bacterium Mycobacterium tuberculosis, was the leading cause of mortality worldwide in 2019 due to a single infectious agent. The growing threat of strains of M.
Mark Laws, Peiqin Jin, K. Rahman
semanticscholar +1 more source
European Journal of Pharmacology, 2021
The potential for the build-up of resistance to a particular antibiotic endangers its therapeutic application over time. In recent decades, antibiotic resistance has become one of the most severe threats to public health.
Vaibhav Thakur, Ankit Uniyal, V. Tiwari
semanticscholar +1 more source
The potential for the build-up of resistance to a particular antibiotic endangers its therapeutic application over time. In recent decades, antibiotic resistance has become one of the most severe threats to public health.
Vaibhav Thakur, Ankit Uniyal, V. Tiwari
semanticscholar +1 more source