Results 241 to 250 of about 985,633 (279)

Multidrug Efflux Pumps in the Genus Erwinia: Physiology and Regulation of Efflux Pump Gene Expression

2016
Plant pathogens belonging to the genus Erwinia cause diseases in several economically important plants. Plants respond to bacterial infection with a powerful chemical arsenal and signaling molecules to rid themselves of the microbes. Although our understanding of how Erwinia initiate infections in plants has become clear, a comprehensive understanding ...
J, Thekkiniath, R, Ravirala, M, San Francisco   +2 more
openaire   +2 more sources

Efflux pumps of Gram-negative bacteria in brief

, 2020
The development of multidrug resistance in Gram-negative bacteria is a major problem faced antimicrobial therapy and management of infectious diseases.
I. G. Auda, I. Salman, Jameelah Gh. Odah
semanticscholar   +1 more source

New-generation efflux pump inhibitors

Expert Review of Clinical Pharmacology, 2008
The development of novel efflux pump inhibitors is an emerging and challenging research field. Besides the use of such excipients in cancer therapy, efflux pump inhibitors are gaining increasing interest with regards to drug delivery. In particular, inhibition of efflux pumps located in the intestine and the blood-brain barrier offers promising ...
Martin, Werle, Hirofumi, Takeuchi, Andreas, Bernkop-Schnürch   +2 more
openaire   +2 more sources

Inhibition of the multidrug resistance efflux pump

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1993
An ATP-dependent efflux pump is found in the plasma membrane of certain multidrug resistant (MDR) cancer cells. Drug resistance is due to decreased intracellular drug levels that have been reduced to subcytotoxic concentrations. Inhibition of the MDR efflux pump with a reversal agent may 'trap' the cytotoxic drug inside the cell; thus, cellular drug ...
P W, Wigler, F K, Patterson
openaire   +2 more sources

Epidemiology of efflux pumps genes mediating resistance among Staphylococcus aureus; A systematic review.

Microbial Pathogenesis, 2019
BACKGROUND Efflux of antibiotics is an effective resistance mechanism among antibiotic-resistant Staphylococcus aureus. This systematic review aims to evaluate the frequency and expression of efflux pump genes in S.aureus around the world.
Sepideh Hassanzadeh, Sara Ganjloo, M. Pourmand, R. Mashhadi, K. Ghazvini   +4 more
semanticscholar   +1 more source

Efflux pump activity in Enchytraeidae

2019
Enchytraeids are ecologically relevant soil organisms, which play an important role in organic matter decomposition and soil bioturbation. They live in close contact with the pore water fraction of soil which makes them vulnerable to xenobiotics exposure.
Hackenberger Kutuzović, Davorka, Lončarić, Željka, Hackenberger Kutuzović, Branimir, Kovačević, Marija   +3 more
openaire   +1 more source

Inhibitors of Efflux Pumps

Multidrug-resistant bacteria are a major public health threat. MDR efflux pump overexpression and enzymatic changes are major antibiotic resistance mechanisms. Many drug and biofilm resistance strategies involve efflux pumps. Natural substrate and inhibitor identification is a new study. Efflux pump inhibition allows medication buildup inside bacterial
Neeraj Kumar, Sudeshna Bhattacharjee, Rama Tyagi   +2 more
openaire   +1 more source

Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii

Journal of Bacteriology, 2018
Antibiotic-resistant Acinetobacter baumannii causes infections that are extremely difficult to treat. A significant role in these resistance profiles is attributed to multidrug efflux pumps, especially those belonging to the resistance-nodulation-cell ...
I. V. Leus, Jon W. Weeks, Vincent Bonifay, Lauren Smith, Sophie Richardson, H. Zgurskaya   +5 more
semanticscholar   +1 more source

Microbial Efflux of Antibiotics and Inhibitors of Efflux Pumps

2014
Detergent-like bile salts kill bacterial cells by destroying bacterial multidrug resistance (MDR) efflux systems. These not only play an important role in antibacterial resistance but also contribute to bacterial pathogenesis. Reserpine and H+/K+ ATPase inhibitors can significantly reduce MICs, increase killing activity, and prolong the postantibiotic ...
openaire   +1 more source

A genetic platform to investigate the functions of bacterial drug efflux pumps

Nature Chemical Biology, 2022
Tanisha Teelucksingh, Laura K. Thompson, Shawna Zhu, Noah M. Kuehfuss, James A. Goetz, S. Gilbert, C. MacNair, J. Geddes-McAlister, E. Brown, G. Cox   +9 more
semanticscholar   +1 more source