Results 231 to 240 of about 985,633 (279)

Focused review on dual inhibition of quorum sensing and efflux pumps: A potential way to combat multi drug resistant Staphylococcus aureus infections.

International Journal of Biological Macromolecules, 2021
Staphylococcus aureus is a common cause of skin infections, food poisoning and severe life-threatening infections. Methicillin-Resistant Staphylococcus aureus (MRSA) is known to cause chronic nosocomial infections by virtue of its multidrug resistance ...
Bawandeep Kaur, J. Gupta, Saurabh Sharma, D. Sharma, Sandeep Sharma   +4 more
semanticscholar   +1 more source

An Overview of Bacterial Efflux Pumps and Computational Approaches to Study Efflux Pump Inhibitors

Future Medicinal Chemistry, 2016
Micro-organisms express a wide range of transmembrane pumps known as multidrug efflux pumps that improve the micro-organism's ability to survive in severe environments and contribute to resistance against antibiotic and antimicrobial agents. There is significant interest in developing efflux inhibitors as an adjunct to treatment with current and next ...
Jamshidi, Shirin, Sutton, Mark, Rahman, Khondaker Mirazur   +2 more
openaire   +3 more sources

Efflux pump inhibitors: new updates

Pharmacological Reports, 2020
The discovery of antibiotics ought to have ended the issue of bacterial infections, but this was not the case as it has led to the evolution of various mechanisms of bacterial resistance against various antibiotics. The efflux pump remains one of the mechanisms through which organisms develop resistance against antibiotics; this is because organisms ...
Manaf AlMatar, Osman Albarri, Essam A. Makky, Fatih Köksal   +3 more
openaire   +2 more sources

Computational modelling of efflux pumps and their inhibitors [PDF]

Essays in Biochemistry, 2017
Antimicrobial resistance is based on the multifarious strategies that bacteria adopt to face antibiotic therapies, making it a key public health concern of our era. Among these strategies, efflux pumps (EPs) contribute significantly to increase the levels and profiles of resistance by expelling a broad range of unrelated compounds – buying time for the
RAMASWAMY, VENKATA KRISHNAN, CACCIOTTO, PIERPAOLO, MALLOCI, GIULIANO, VARGIU, ATTILIO VITTORIO, RUGGERONE, PAOLO   +4 more
openaire   +2 more sources

Bacterial Efflux Pump Inhibitors

2008
Infections caused by multidrug-resistant Gram-negative pathogens play a major role in the morbidity and mortality of hospitalized patients. The rise of resistance to current antibiotic therapies has made the discovery of new agents urgent. One of the major antibiotic resistance mechanisms utilized by more than 15 species of Gram-negative bacterial ...
Barbara J, Kamicker, Michael T, Sweeney, Frank, Kaczmarek, Fadia, Dib-Hajj, Wenchi, Shang, Kim, Crimin, Joan, Duignan, Thomas D, Gootz   +7 more
openaire   +2 more sources

Bacterial efflux systems and efflux pumps inhibitors

Biochimie, 2005
It is now well established that bacterial resistance to antibiotics has become a serious problem of public health that concerns almost all antibacterial agents and that manifests in all fields of their application. Among the three main mechanisms involved in bacterial resistance (target modification, antibiotic inactivation or default of its ...
openaire   +2 more sources

RND efflux pumps in Gram-negative bacteria; regulation, structure and role in antibiotic resistance.

Future Microbiology, 2020
Rresistance-nodulation-division (RND) efflux pumps in Gram-negative bacteria remove multiple, structurally distinct classes of antimicrobials from inside bacterial cells therefore directly contributing to multidrug resistance.
A. Colclough, Ilyas Alav, Emily E. Whittle, Hannah L. Pugh, Elizabeth M. Darby, S. Legood, Helen Mcneil, J. Blair   +7 more
semanticscholar   +1 more source

Efflux Pumps in Drug Resistance of Candida

Infectious Disorders - Drug Targets, 2006
The incidences of human pathogenic yeast Candida albicans and its related species acquiring resistance to antifungals have increased considerably, which poses serious problems towards its successful chemotherapy. The resistance of these pathogenic fungi is not restricted to the commonly used triazole compounds but is even encountered, though not often,
R, Prasad, N A, Gaur, M, Gaur, S S, Komath   +3 more
openaire   +2 more sources

Efflux pumps and mutation

Science, 2018
Antibiotic Resistance Antibiotic resistance is an alarming and growing challenge. Bacteria show great heterogeneity in growth and mutation rates. Such variability allows some cells to persist during transient antibiotic exposure. During this persistent phase, mutations accumulate, which can result in selection for full-blown antibiotic resistance.
openaire   +1 more source

Efflux pumps as interventions to control infection caused by drug-resistance bacteria.

Drug Discovery Today, 2020
Bacterial multidrug resistance (MDR) has become a major public health threat. Along with enzymatic modifications, overexpression of MDR efflux pumps is a significant antibiotic resistance mechanism.
Nabeela Farhat, A. Ali, R. Bonomo, Asad U. Khan   +3 more
semanticscholar   +1 more source