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Bacterial Multidrug Efflux Pumps: Much More Than Antibiotic Resistance Determinants [PDF]
Microorganisms, 2016 Bacterial multidrug efflux pumps are antibiotic resistance determinants present in all microorganisms. With few exceptions, they are chromosomally encoded and present a conserved organization both at the genetic and at the protein levels.
Alejandra Bernardini +2 more
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How resistance-nodulation-division (RND) efflux pumps contribute to virulence. [PDF]
PLoS PathogensIn Gram-negative bacteria, multi-subunit efflux pumps transport molecules across the inner membrane, periplasm, and outer membrane to the extracellular environment.
Corrella S Detweiler, Ilyas Alav
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Efflux pumps: gatekeepers of antibiotic resistance in Staphylococcus aureus biofilms [PDF]
Microbial CellStaphylococcus aureus, a versatile human pathogen, poses a significant challenge in healthcare settings due to its ability to develop antibiotic resistance and form robust biofilms.
Shweta Sinha +2 more
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Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
Frontiers in Microbiology, 2021 Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug
Martijn Zwama +2 more
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Biofilm Formation and the Role of Efflux Pumps in ESKAPE Pathogens [PDF]
MicroorganismsNosocomial infections caused by ESKAPE pathogens represent a significant burden to global health. These pathogens may exhibit multidrug resistance (MDR) mechanisms, of which mechanisms such as efflux pumps and biofilm formation are gaining significant ...
Trent R. Sorenson +2 more
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Versatility of Stenotrophomonas maltophilia: Ecological roles of RND efflux pumps
Heliyon, 2023 S. maltophilia is a widely distributed bacterium found in natural, anthropized and clinical environments. The genome of this opportunistic pathogen of environmental origin includes a large number of genes encoding RND efflux pumps independently of the ...
Amandine Chauviat +2 more
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Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview
Antibiotics, 2022 Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by decreasing the intracellular concentration of drugs. This protective barrier consists of a series of transporter proteins, which are located in the bacterial ...
Xu Wang, Menghong Dai, Lingli Huang
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Antibiotics, 2023 Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections.
Asiyeh Avakh +4 more
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Functional interplay between RND efflux pumps and GacS in Pseudomonas aeruginosa [PDF]
Applied and Environmental MicrobiologyPseudomonas aeruginosa is an opportunistic human pathogen that is ubiquitous in the environment. The environmental versatility of P. aeruginosa is often attributed to a large arsenal of active efflux pumps, low permeability of the outer membrane, and ...
Justyna W. Adamiak +6 more
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Flavonoids as Inhibitors of Bacterial Efflux Pumps [PDF]
Molecules, 2021 Flavonoids are widely occurring secondary plant constituents, and are abundant in vegetable and fruit diets as well as herbal medicines. Therapeutic treatment options for bacterial infections are limited due to the spread of antimicrobial resistances.
Franz Bucar
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