Results 31 to 40 of about 180,666 (287)

Role of efflux pumps, their inhibitors, and regulators in colistin resistance

Frontiers in Microbiology, 2023
Colistin is highly promising against multidrug-resistant and extensively drug-resistant bacteria clinically. Bacteria are resistant to colistin mainly through mcr and chromosome-mediated lipopolysaccharide (LPS) synthesis-related locus variation. However,
Yinhuan Ding, Jingchen Hao, Weijia Xiao, Caihong Ye, Xue Xiao, Chunxia Jian, Min Tang, Guangrong Li, Jinbo Liu, Zhangrui Zeng   +9 more
doaj   +1 more source

Microbial Primer: Multidrug efflux pumps [PDF]

, 2023
Multidrug efflux pumps are molecular machines that sit in the bacterial cell membrane and pump molecules out from either the periplasm or cytoplasm to outside the cell.
Blair, Jessica M A; id_orcid, Jessica M. A. Blair, Siasat, Pauline Ann; id_orcid, Pauline Ann Siasat   +3 more
core   +1 more source

Plant Metabolites as Potential Agents That Potentiate or Block Resistance Mechanisms Involving β-Lactamases and Efflux Pumps. [PDF]

Int J Mol Sci
The dramatic increase in antimicrobial resistance (AMR) in recent decades has created an urgent need to develop new antimicrobial agents and compounds that can modify and/or block bacterial resistance mechanisms.
Zai MJ, Cock IE, Cheesman MJ.
europepmc   +2 more sources

The Two-Component System RstA/RstB Regulates Expression of Multiple Efflux Pumps and Influences Anaerobic Nitrate Respiration in Pseudomonas fluorescens

mSystems, 2021
Multidrug resistance (MDR) efflux pumps are involved in bacterial intrinsic resistance to multiple antimicrobials. Expression of MDR efflux pumps can be either constitutive or transiently induced by various environmental signals, which are typically ...
Di-Yin Li, Jian-Ting Han, Meng-Yuan Zhang, Xu Yan, Nannan Zhang, Honghua Ge, Zhiping Wang, Yong-Xing He   +7 more
doaj   +1 more source

efflux-pumps inhibitors

, 2022
Archive of efflux-pumps inhibitors containing sub-folders named after each compound and its net charge. Every compound's folder contains a total of 20 files distributed into three sub-directories reporting QM (QM/), FF (FF/), and MD (MD ...
Giuliano Malloci (2060875), Silvia Gervasoni (6169202), Andrea Bosin (6743129), Helen I. Zgurskaya (3093648), Attilio Vittorio Vargiu (2358538), Paolo Ruggerone (247673)   +5 more
core   +1 more source

Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence

Frontiers in Microbiology, 2016
Multidrug efflux pumps can be involved in bacterial resistance to antibiotics at different levels. Some efflux pumps are constitutively expressed at low levels and contribute to intrinsic resistance.
Manuel Alcalde-Rico, Sara Hernando-Amado, Paula Blanco, Jose L Martinez   +3 more
doaj   +1 more source

Ever-Adapting RND Efflux Pumps in Gram-Negative Multidrug-Resistant Pathogens: A Race against Time

Antibiotics, 2021
The rise in multidrug resistance (MDR) is one of the greatest threats to human health worldwide. MDR in bacterial pathogens is a major challenge in healthcare, as bacterial infections are becoming untreatable by commercially available antibiotics. One of
Martijn Zwama, Kunihiko Nishino
doaj   +1 more source

Antimicrobial and Efflux Pump Inhibitory Activity of Caffeoylquinic Acids from Artemisia absinthium against Gram-Positive Pathogenic Bacteria [PDF]

, 2010
Background: Traditional antibiotics are increasingly suffering from the emergence of multidrug resistance amongst pathogenic bacteria leading to a range of novel approaches to control microbial infections being investigated as potential alternative ...
Han Haley, Jacques Vervoort, Alexandre M. J. J. Bonvin, George P Tegos, Lewis Kim, Panagiotis L. Kastritis, Vervoort, J., NMR Spectroscopy, Michael R. Hamblin, Kastritis, P., Vervoort Jacques, Exarchou, Vassiliki, Vervoort, Jacques, Bonvin, A.M., Kastritis Panagiotis L., Hamblin, Michael, Tegos, George, Tegos, George P., Lewis, K., Kim Lewis, George P. Tegos, Bonvin, Alexandre M. J. J., Panagiotis L Kastritis, Bonvin Alexandre M. J. J., Sub NMR Spectroscopy, Han, H., Tegos, G.P., Alexandre M J J Bonvin, Fiamegos Yiannis C., Fiamegos, Y.C., Yiannis C Fiamegos, Kastritis, P.L., Hamblin, Michael R., Exarchou Vassiliki, Lewis, Kim, Exarchou, V., Han, Haley, Hamblin Michael R., Tegos George P., Michael R Hamblin, Fiamegos, Yiannis C., Haley Han, Yiannis C. Fiamegos, Kastritis, Panagiotis L., Vassiliki Exarchou, Bonvin, A.M.J.J., Hamblin, M.R., Vervoort, J.J.M.   +47 more
core   +3 more sources

The Varied Role of Efflux Pumps of the MFS Family in the Interplay of Bacteria with Animal and Plant Cells

Microorganisms, 2019
Efflux pumps represent an important and large group of transporter proteins found in all organisms. The importance of efflux pumps resides in their ability to extrude a wide range of antibiotics, resulting in the emergence of multidrug resistance in many
Martina Pasqua, Milena Grossi, Alessandro Zennaro, Giulia Fanelli, Gioacchino Micheli, Frederic Barras, Bianca Colonna, Gianni Prosseda   +7 more
doaj   +1 more source

Nanoparticles as Efflux Pump and Biofilm Inhibitor to Rejuvenate Bactericidal Effect of Conventional Antibiotics

Nanoscale Research Letters, 2017
The universal problem of bacterial resistance to antibiotic reflects a serious threat for physicians to control infections. Evolution in bacteria results in the development of various complex resistance mechanisms to neutralize the bactericidal effect of
Divya Gupta, Ajeet Singh, Asad U. Khan
doaj   +1 more source