Results 141 to 150 of about 54,202 (287)

Current Advances in Developing Inhibitors of Bacterial Multidrug Efflux Pumps

, 2016
Antimicrobial resistance represents a significant challenge to future healthcare provision. An acronym ESKAPEE has been derived from the names of the organisms recognised as the major threats although there are a number of other organisms, notably ...
Mahmood, Hannah Y., Sutton, J. Mark, Rahman, Khondaker M.; id_orcid, Jamshidi, Shirin; id_orcid   +3 more
core   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Understanding the role of multidrug efflux pumps in Shigella

, 2018
The efflux pumps represent an important and consistent group of proteins involved in transport process present in all living cells. The importance of efflux pumps in bacteria has always been associated to their ability to extrude a wide range of ...
Milena Grossi, Sara Scinicariello, Bianca Colonna, Laurent Aussel, Gianni Prosseda, Martina Pasqua, Frederic Barras   +6 more
core  

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Bioinspired Passive Flow Routing to Mitigate Thrombosis in Prosthetic Heart Valves and Cardiovascular Devices

Advanced Science, EarlyView.
Bioinspired passive flow routing mitigates thrombosis in cardiovascular devices by redirecting a small fraction of forward flow into stagnation‐prone regions. Inspired by avian alula and aircraft slat mechanisms, strategically placed routing channels restore washout around mechanical heart valves, reducing low‐shear exposure by four orders of magnitude
Yevgeniy Kreinin, Mark Epshtein, Yahel Talmon, Tirosh Mekler, Itay Or, Mahli Raad, Gil Bolotin, Josué Sznitman, Netanel Korin   +8 more
wiley   +1 more source

Expression profile of EmrKY efflux pumps during Shigella's intracellular life

, 2017
Backgrounds In several bacterial pathogens, efflux pumps, besides exporting antimicrobial agents, play a role in bacterial pathogenicity. Shigella, the causative agent of bacillary dysentery, has conserved 14 out of 20 operons encoding efflux pumps ...
Milena Grossi, Maria Letizia Di Martino, Bianca Colonna, Laurent Aussel, Gianni Prosseda, Martina Pasqua, Frederic Barras   +6 more
core  

Self‐Sustaining Lactate Depletion Nanoplatform Remodels Tumor Microenvironment and Augments Synergistic Photodynamic/Photothermal/Chemodynamic/Starvation Therapy for Eradication of Colon Cancer

Advanced Science, EarlyView.
The HILA nanoplatform integrates HMnO2, LOX, and ICG to orchestrate multimodal therapy (starvation, chemodynamic, photodynamic, and photothermal) for achieving efficient colon cancer eradication. The established HMnO2‐LOX catalytic cycle continuously consumes lactate, acidifys microenvironment, relieves hypoxia, and generats reactive oxygen species ...
Yu‐E. Wang, Shibo Zhao, Wenying Wu, Zhiwei Duan, Yuan Li, Xiangyu Zeng, Liang Hong, Yan Chen, Ling Tao, Kewu Zeng, Chaoda Xiao, Xiangchun Shen   +11 more
wiley   +1 more source

Efflux pumps of Mycobacterium tuberculosis play a significant role in antituberculosis activity of potential drug candidates

, 2012
Active efflux of drugs mediated by efflux pumps that confer drug resistance is one of the mechanisms developed by bacteria to counter the adverse effects of antibiotics and chemicals.
A Nair (13729120), N Dinesh (13729117), U Sharma (13309755), S Sharma (7065461), S Kuruppath (13662376), M Balganesh (13729114)   +5 more
core  

Curvature‐Controlled Field Effect Enables Thermal Localization for Low‐Temperature C─F Bond Activation

Advanced Science, EarlyView.
High‐curvature γ‐Al2O3 nanoneedles concentrate heat into nanoscale hotspots under identical external heating, amplifying local temperature and accelerating CF4 decomposition. By linking curvature‐induced thermal localization to lower apparent activation barriers and enhanced intermediate formation, this work reveals geometry as a powerful design ...
Hang Zhang, Jialin Zheng, Xiaojian Wang, Hao Yu, Diya Xie, Wenjie Luo, Minghui Yang, Kang Liu, Yuxia Duan, Zhang Lin, Liyuan Chai, Emiliano Cortés, Min Liu   +12 more
wiley   +1 more source

Evaluation of the Phenotypic and Molecular Pattern of Efflux Pumps in Clinical Isolates of Methicillin-resistant Staphylococcus aureus

پزشکی بالینی ابن سینا, 2017
Background and Objective: Efflux pumps are regarded as one of the most important mechanisms of antibiotic resistance in this era. Staphylococcus aureus is one of the bacterial groups with efflux pumps. The pumps’ activity is coded by specific genes.
J Ghaderkhani, H Tahmasebi, B Zeyni, S Dehbashi, MR Arabestani   +4 more
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