Results 181 to 190 of about 90,161 (342)

Traceless Regulation of Genetic Circuitry

Advanced Science, EarlyView.
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Sarothrin from Alkanna orientalis Is an Antimicrobial Agent and Efflux Pump Inhibitor [PDF]

, 2013
Jessica Bame, Tyler N. Graf, Hiyas A. Junio, RO Bussey, Scott A. Jarmusch, Tamam El‐Elimat, Joseph O. Falkinham, Nicholas H. Oberlies, Richard A Cech, Nadja B. Cech   +9 more
openalex   +1 more source

Gut Microbe‐Driven Resistance Mechanisms in Propylea Japonica: Insights from Horizontal Gene Transfer and Oxidative Phosphorylation

Advanced Science, EarlyView.
Acinetobacter regulates dinotefuran tolerance in Propylea japonica by mediating the expression of the horizontally transferred gene PjDUF1. Abstract Insect–microbial symbiont relationships are widespread in nature and often involve lateral gene transfer.
Ningbo HuangFu, Xiangzhen Zhu, Zhijuan Tang, Li Wang, Kaixin Zhang, Dongyang Li, Jichao Ji, Jinjie Cui, Zhaojiang Guo, Junyu Luo, Xueke Gao   +10 more
wiley   +1 more source

Reconstructing Coherent Functional Landscape From Multi‐Modal Multi‐Slice Spatial Transcriptomics by a Variational Spatial Gaussian Process

Advanced Science, EarlyView.
This study introduces stVGP, a variational spatial Gaussian process framework for multi‐modal, multi‐slice spatial transcriptomics. By integrating histological and genomic data through hybrid alignment and attention‐based fusion, stVGP reconstructs coherent 3D functional landscapes.
Zedong Wang, Bowen Fu, Chuanchao Zhang, Xiaoping Liu   +3 more
wiley   +1 more source

Antibiotic-potentiation activities of four Cameroonian dietary plants against multidrug-resistant Gram-negative bacteria expressing efflux pumps [PDF]

, 2014
Francesco K. Touani, Armel Jackson Seukep, Doriane E. Djeussi, Aimé G. Fankam, Jaurès A. K. Noumedem, Victor Kuete   +5 more
openalex   +1 more source

Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps

, 2022
Coline Plé, Heng-Keat Tam, Anaïs Vieira Da Cruz, Nina Compagne, Juan-Carlos Jiménez-Castellanos, Reinke T. Müller, Elizabeth Pradel, Wuen Ee Foong, Giuliano Malloci, Alexia Ballée, Moritz A Kirchner, Parisa Moshfegh, Adrien Herlédan, Andrea Herrmann, Benoît Déprez, Nicolas Willand, Attilio V. Vargiu, Klaas M. Pos, Marion Flipo, Ruben C. Hartkoorn   +19 more
openalex   +1 more source

Polyoxometalate as Hydrogen–Electron Hub in Metal–Organic Complex for Electrocatalytic Nitrate Reduction to Ammonia

Advanced Science, EarlyView.
To tackle low electrocatalytic nitrate reduction to ammonia efficiency in neutral media, this work designs chain‐like dinuclear/trinuclear polyoxometalate‐based metal‐organic complexes. Metal clusters provide nitrate adsorption/activation sites, while polyoxometalates (POMs) drive water dissociation to generate active hydrogen (*H) that migrates to ...
Qiushuang Jiang, Xinming Wang, Shengji Tian, Haijun Pang, Yongbin Song, Huiyuan Ma   +5 more
wiley   +1 more source

Beyond antibiotic resistance: evidence for resistance-nodulation-division (RND) efflux pumps as virulence determinants. [PDF]

Microbiol Mol Biol Rev
Detweiler CS, Alav I.
europepmc   +1 more source

AcrAB Efflux Pump Plays a Crucial Role in Bile Salts Resistance and Pathogenesis of Klebsiella pneumoniae [PDF]

Rundong Shu, Ge Liu, Yayun Xu, Bojun Liu, Zhi Huang, Hui Wang   +5 more
openalex   +1 more source