Results 221 to 230 of about 54,202 (287)

Effect of temperature on the activity of efflux pumps in selected species of human opportunistic bacterial pathogens. [PDF]

Mem Inst Oswaldo Cruz
Hurton D, Hleba L, Petrová J, Laho M, Koren J, Liptáková A.   +5 more
europepmc   +1 more source

Waste activated sludge high‐rate treatment of septage: Stabilization phase trials and comparison with winery wastewater treatment

The Canadian Journal of Chemical Engineering, EarlyView.
Performance evaluation of the waste activated sludge high‐rate (WASHR) process for septic wastewater treatment. Abstract The waste‐activated sludge high‐rate (WASHR) process is evaluated as a batch‐mode pre‐treatment for actual septage using a high‐rate contact stabilization (HRCS) approach.
Arman Shirali, Melody Blythe Johnson, Mehrab Mehrvar   +2 more
wiley   +1 more source

Inhibition of efflux pumps by FDA-approved drugs oxiconazole and sertaconazole restores antibiotic susceptibility in multidrug-resistant <i>S. aureus</i>. [PDF]

Antimicrob Agents Chemother
Ojha S, Chatterjee P, Beuria TK.
europepmc   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Whole-Genome Sequence Analysis to Assess Mutations in Efflux Pumps in <i>Mycobacterium tuberculosis</i>: The Influence in Drug Resistance. [PDF]

Microorganisms
Chimal-Muñoz M, Pérez-Martínez DE, Bermúdez Hernández GA, Mejía-Ponce PM, Licona-Cassani C, Muñiz-Salazar R, Montero H, Zenteno-Cuevas R.   +7 more
europepmc   +1 more source

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

Targeting efflux pumps prevents the multi-step evolution of high-level resistance to fluoroquinolone in Pseudomonas aeruginosa. [PDF]

Microbiol Spectr
Yu X-Q, Yang H, Feng H-Z, Hou J, Tian J-Q, Niu S-M, You C-G, Tao X-Y, Zhang S-P, Wang Z-P, He Y-X.   +10 more
europepmc   +1 more source

Dynamic manipulation of multiphase fluid in microgravity using photoresponsive surfactant

Droplet, EarlyView.
Photo‐surfactant‐driven bubble migration experiment was conducted onboard the International Space Station to isolate Marangoni flow from gravity and natural convection. The experiment identifies an optimal bubble size leading to the highest migration velocity, which is validated with a comprehensive numerical model. Abstract Control of bubble motion is
Xichen Liang, Kseniia M. Karnaukh, Qixuan Cao, Marielle Cooper, Hao Xu, Ian Maskiewicz, Olivia Wander, Javier Read de Alaniz, Yangying Zhu, Paolo Luzzatto‐Fegiz   +9 more
wiley   +1 more source

Helicobacter pylori Efflux Pumps: A Double-Edged Sword in Antibiotic Resistance and Biofilm Formation. [PDF]

Int J Mol Sci
Krzyżek P.
europepmc   +1 more source

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source