Results 241 to 250 of about 54,202 (287)

C7-Substituted Quinolines as Potent Inhibitors of AdeG Efflux Pumps in <i><i>Acinetobacter baumannii</i></i>. [PDF]

ACS Infect Dis
Zhu Y, Hind CK, Al-Adhami T, Wand ME, Clifford M, Sutton JM, Rahman KM.   +6 more
europepmc   +1 more source

Natural Inhibitors of Salmonella MDR Efflux Pumps AcrAB and AcrD: An Integrated In Silico, Molecular, and In Vitro Investigation. [PDF]

Int J Mol Sci
El-Demerdash AS, Kamel SA, Elariny EYT, Henidi H, Mahran Y, Alahdal H, Saleh AM, Ibrahim RA.   +7 more
europepmc   +1 more source

Contribution of RND superfamily multidrug efflux pumps AdeABC, AdeFGH, and AdeIJK to antimicrobial resistance and virulence factors in multidrug-resistant <i>Acinetobacter baumannii</i> AYE. [PDF]

Antimicrob Agents Chemother
Xie L, Li J, Peng Q, Liu X, Lin F, Dai X, Ling B.   +6 more
europepmc   +1 more source

Antibiotic efflux pumps

Biochemical Pharmacology, 2000
Active efflux from procaryotic as well as eucaryotic cells strongly modulates the activity of a large number of antibiotics. Effective antibiotic transport has now been observed for many classes of drug efflux pumps. Thus, within the group of primary active transporters, predominant in eucaryotes, six families belonging to the ATP-binding cassette ...
F, Van Bambeke, E, Balzi, P M, Tulkens
openaire   +3 more sources

An Overview of Bacterial Efflux Pumps and Computational Approaches to Study Efflux Pump Inhibitors

Future Medicinal Chemistry, 2016
Micro-organisms express a wide range of transmembrane pumps known as multidrug efflux pumps that improve the micro-organism's ability to survive in severe environments and contribute to resistance against antibiotic and antimicrobial agents. There is significant interest in developing efflux inhibitors as an adjunct to treatment with current and next ...
Jamshidi, Shirin, Sutton, Mark, Rahman, Khondaker Mirazur   +2 more
openaire   +4 more sources

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Mycobacterial efflux pumps and chemotherapeutic implications

International Journal of Antimicrobial Agents, 2003
The demonstration of the existence of active efflux pumps in mycobacteria raises the question of whether or not these can increase in number and activity rendering wild-type mycobacteria increasingly resistant to a given antibiotic. This could be a mechanism by which mutated resistant strains become better fit to the selective environment ...
MIGUEL Viveiros, Clara Leandro, Leonard Amaral   +2 more
exaly   +3 more sources

Leishmaniasis: efflux pumps and chemoresistance

International Journal of Antimicrobial Agents, 2003
Resistance of parasitic protozoa such as Leishmania to therapeutic drugs continues to escalate in developing countries. Treatment programs for human leishmaniasis are still based on pentavalent antimonials but resistance to these compounds has been a persistent problem.
Clara, Leandro, Lenea, Campino
openaire   +2 more sources

Antimicrobial Resistance: Two-Component Regulatory Systems and Multidrug Efflux Pumps

Antibiotics, 2023
The number of multidrug-resistant bacteria is rapidly spreading worldwide. Among the various mechanisms determining resistance to antimicrobial agents, multidrug efflux pumps play a noteworthy role because they export extraneous and noxious substrates ...
Giuseppe Valerio de Gaetano, Germana Lentini, Francesco Coppolino   +2 more
exaly   +2 more sources

Computational modelling of efflux pumps and their inhibitors [PDF]

Essays in Biochemistry, 2017
Antimicrobial resistance is based on the multifarious strategies that bacteria adopt to face antibiotic therapies, making it a key public health concern of our era. Among these strategies, efflux pumps (EPs) contribute significantly to increase the levels and profiles of resistance by expelling a broad range of unrelated compounds – buying time for the
RAMASWAMY, VENKATA KRISHNAN, CACCIOTTO, PIERPAOLO, MALLOCI, GIULIANO, VARGIU, ATTILIO VITTORIO, RUGGERONE, PAOLO   +4 more
openaire   +2 more sources