Results 261 to 270 of about 54,202 (287)

Determination of the Efflux Pump-Mediated Resistance Prevalence in Pseudomonas aeruginosa, Using an Efflux Pump Inhibitor

Current Microbiology, 2009
In gram negative bacteria, fluoroquinolone resistance is acquired by target mutations in topoisomerase genes or by reducing the permeation of drugs due to the increase in expression of endogenous multidrug efflux pumps that expel structurally unrelated antimicrobial agents.
Abolghasem, Tohidpour, Shahin, Najar Peerayeh, Jalil F, Mehrabadi, Hadi, Rezaei Yazdi   +3 more
openaire   +2 more sources

Efflux pump activity in Enchytraeidae

2019
Enchytraeids are ecologically relevant soil organisms, which play an important role in organic matter decomposition and soil bioturbation. They live in close contact with the pore water fraction of soil which makes them vulnerable to xenobiotics exposure.
Hackenberger Kutuzović, Davorka, Lončarić, Željka, Hackenberger Kutuzović, Branimir, Kovačević, Marija   +3 more
openaire   +1 more source

Inhibitors of Efflux Pumps

Multidrug-resistant bacteria are a major public health threat. MDR efflux pump overexpression and enzymatic changes are major antibiotic resistance mechanisms. Many drug and biofilm resistance strategies involve efflux pumps. Natural substrate and inhibitor identification is a new study. Efflux pump inhibition allows medication buildup inside bacterial
Neeraj Kumar, Sudeshna Bhattacharjee, Rama Tyagi   +2 more
openaire   +1 more source

Cholestasis and the Role of Basolateral Efflux Pumps

Zeitschrift für Gastroenterologie, 2011
ATP-dependent transport of biliary constituents, such as bile acids, reduced glutathione, and bilirubin glucuronosides across the hepatocyte canalicular membrane into bile represents the decisive driving force for the formation of biliary fluid. Functional characterization, cloning, and localization of hepatocellular transporter proteins has provided a
openaire   +2 more sources

Microbial Efflux of Antibiotics and Inhibitors of Efflux Pumps

2014
Detergent-like bile salts kill bacterial cells by destroying bacterial multidrug resistance (MDR) efflux systems. These not only play an important role in antibacterial resistance but also contribute to bacterial pathogenesis. Reserpine and H+/K+ ATPase inhibitors can significantly reduce MICs, increase killing activity, and prolong the postantibiotic ...
openaire   +1 more source

Natural Product as Efflux Pump Inhibitors Against MRSA Efflux Pumps: An Update

2022
Pallavi Ahirrao, Ritu Kalia, Sanjay M. Jachak   +2 more
openaire   +1 more source

Strategies to Overcome Efflux Pumps

2009
Intestinal efflux pumps such as P-glycoprotein play a significant role in altering the absorption of a wide range of drugs. Anticancer agents, antibiotics, antivirals, calcium channel blockers, immunosuppressive agents, peptide drugs and several other therapeutic compounds have been reported to be substrates of one or more transmembrane efflux ...
openaire   +1 more source

Update on Multidrug Resistance Efflux Pumps in Acinetobacter spp.

Antimicrobial Agents and Chemotherapy, 2021
Vanessa Kornelsen, Ayush Kumar
exaly  

Efflux Pumps

RCSB Protein Data Bank
Steven Arnold, Shuchismita Dutta
openaire   +1 more source

Efflux pumps in multidrug-resistant Acinetobacter baumannii: Current status and challenges in the discovery of efflux pumps inhibitors

Microbial Pathogenesis, 2021
Monalisa Tiwari, Vishvanath Tiwari
exaly