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Bacterial Efflux Pump Inhibitors
2008Infections caused by multidrug-resistant Gram-negative pathogens play a major role in the morbidity and mortality of hospitalized patients. The rise of resistance to current antibiotic therapies has made the discovery of new agents urgent. One of the major antibiotic resistance mechanisms utilized by more than 15 species of Gram-negative bacterial ...
Barbara J, Kamicker +7 more
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Bacterial efflux systems and efflux pumps inhibitors
Biochimie, 2005It is now well established that bacterial resistance to antibiotics has become a serious problem of public health that concerns almost all antibacterial agents and that manifests in all fields of their application. Among the three main mechanisms involved in bacterial resistance (target modification, antibiotic inactivation or default of its ...
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An Overview of Bacterial Efflux Pumps and Computational Approaches to Study Efflux Pump Inhibitors
Future Medicinal Chemistry, 2016Micro-organisms express a wide range of transmembrane pumps known as multidrug efflux pumps that improve the micro-organism's ability to survive in severe environments and contribute to resistance against antibiotic and antimicrobial agents. There is significant interest in developing efflux inhibitors as an adjunct to treatment with current and next ...
Jamshidi, Shirin +2 more
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Science, 2018
Antibiotic Resistance Antibiotic resistance is an alarming and growing challenge. Bacteria show great heterogeneity in growth and mutation rates. Such variability allows some cells to persist during transient antibiotic exposure. During this persistent phase, mutations accumulate, which can result in selection for full-blown antibiotic resistance.
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Antibiotic Resistance Antibiotic resistance is an alarming and growing challenge. Bacteria show great heterogeneity in growth and mutation rates. Such variability allows some cells to persist during transient antibiotic exposure. During this persistent phase, mutations accumulate, which can result in selection for full-blown antibiotic resistance.
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Efflux pump inhibitors in bacteria
Expert Opinion on Therapeutic Patents, 2007The efficacy of antibiotherapy of infectious diseases is strongly compromised by the advent and spread of antibiotic resistance. Active efflux of cytotoxic drugs mediated by multi-drug transporters is the basis of multi-drug resistance in prokaryotic cells.
Sandrine Alibert, Jean-Marie Pagès
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2016
Plant pathogens belonging to the genus Erwinia cause diseases in several economically important plants. Plants respond to bacterial infection with a powerful chemical arsenal and signaling molecules to rid themselves of the microbes. Although our understanding of how Erwinia initiate infections in plants has become clear, a comprehensive understanding ...
J, Thekkiniath +2 more
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Plant pathogens belonging to the genus Erwinia cause diseases in several economically important plants. Plants respond to bacterial infection with a powerful chemical arsenal and signaling molecules to rid themselves of the microbes. Although our understanding of how Erwinia initiate infections in plants has become clear, a comprehensive understanding ...
J, Thekkiniath +2 more
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Multidrug-resistant bacteria are a major public health threat. MDR efflux pump overexpression and enzymatic changes are major antibiotic resistance mechanisms. Many drug and biofilm resistance strategies involve efflux pumps. Natural substrate and inhibitor identification is a new study. Efflux pump inhibition allows medication buildup inside bacterial
Neeraj Kumar +2 more
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Neeraj Kumar +2 more
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Antimicrobial Drug Efflux Pump Inhibitors
2016Bacterial multidrug resistance is on the rise, and bacterial efflux pumps make a major contributor to this development. Efflux pump inhibitors (EPIs) may be a solution to this problem, since they can reverse resistance to clinically administered antimicrobial agents. Multiple EPIs with activity against Gram-positive and Gram-negative bacteria have been
Jürgen A. Bohnert, Winfried V. Kern
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Efflux Pumps in Drug Resistance of Candida
Infectious Disorders - Drug Targets, 2006The incidences of human pathogenic yeast Candida albicans and its related species acquiring resistance to antifungals have increased considerably, which poses serious problems towards its successful chemotherapy. The resistance of these pathogenic fungi is not restricted to the commonly used triazole compounds but is even encountered, though not often,
R, Prasad +3 more
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