Results 291 to 300 of about 90,161 (342)
The importance of heteroresistance and efflux pumps in bedaquiline-resistant Mycobacterium tuberculosis isolates from Iran. [PDF]
Ann Clin Microbiol AntimicrobMadadi-Goli N +9 more
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Inside-out, antimicrobial resistance mediated by efflux pumps in clinical strains of Acinetobacter baumannii isolated from burn wound infections. [PDF]
Braz J MicrobiolHernández-Durán M +10 more
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Anti-virulence and anti-efflux pump activity of synthetic defensins and histatin in Candida auris
Siham Shaban, Mrudula Patel, Aijaz Ahmad
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Inhibition of P-GP efflux pumps and supramaximal effect (SPMX) on in vitro dioxin bioassay
, 2012 Mauricio Montaño +3 more
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Biochemical Pharmacology, 2000
Active efflux from procaryotic as well as eucaryotic cells strongly modulates the activity of a large number of antibiotics. Effective antibiotic transport has now been observed for many classes of drug efflux pumps. Thus, within the group of primary active transporters, predominant in eucaryotes, six families belonging to the ATP-binding cassette ...
F, Van Bambeke, E, Balzi, P M, Tulkens
openaire +2 more sources
Active efflux from procaryotic as well as eucaryotic cells strongly modulates the activity of a large number of antibiotics. Effective antibiotic transport has now been observed for many classes of drug efflux pumps. Thus, within the group of primary active transporters, predominant in eucaryotes, six families belonging to the ATP-binding cassette ...
F, Van Bambeke, E, Balzi, P M, Tulkens
openaire +2 more sources
Efflux pump inhibitors: new updates
Pharmacological Reports, 2020The discovery of antibiotics ought to have ended the issue of bacterial infections, but this was not the case as it has led to the evolution of various mechanisms of bacterial resistance against various antibiotics. The efflux pump remains one of the mechanisms through which organisms develop resistance against antibiotics; this is because organisms ...
Manaf AlMatar +3 more
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New-generation efflux pump inhibitors
Expert Review of Clinical Pharmacology, 2008The development of novel efflux pump inhibitors is an emerging and challenging research field. Besides the use of such excipients in cancer therapy, efflux pump inhibitors are gaining increasing interest with regards to drug delivery. In particular, inhibition of efflux pumps located in the intestine and the blood-brain barrier offers promising ...
Martin, Werle +2 more
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Leishmaniasis: efflux pumps and chemoresistance
International Journal of Antimicrobial Agents, 2003Resistance of parasitic protozoa such as Leishmania to therapeutic drugs continues to escalate in developing countries. Treatment programs for human leishmaniasis are still based on pentavalent antimonials but resistance to these compounds has been a persistent problem.
Clara, Leandro, Lenea, Campino
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Bacterial Efflux Pump Inhibitors
2008Infections caused by multidrug-resistant Gram-negative pathogens play a major role in the morbidity and mortality of hospitalized patients. The rise of resistance to current antibiotic therapies has made the discovery of new agents urgent. One of the major antibiotic resistance mechanisms utilized by more than 15 species of Gram-negative bacterial ...
Barbara J, Kamicker +7 more
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Bacterial efflux systems and efflux pumps inhibitors
Biochimie, 2005It is now well established that bacterial resistance to antibiotics has become a serious problem of public health that concerns almost all antibacterial agents and that manifests in all fields of their application. Among the three main mechanisms involved in bacterial resistance (target modification, antibiotic inactivation or default of its ...
openaire +2 more sources