Results 31 to 40 of about 54,202 (287)
Nanoscale Research Letters, 2017 The universal problem of bacterial resistance to antibiotic reflects a serious threat for physicians to control infections. Evolution in bacteria results in the development of various complex resistance mechanisms to neutralize the bactericidal effect of
Divya Gupta, Ajeet Singh, Asad U. Khan
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Evaluation of Delafloxacin against a Burkholderia pseudomallei Efflux Mutant Panel
Microbiology Spectrum, 2022 In vitro activities of delafloxacin and ciprofloxacin were evaluated against Burkholderia pseudomallei mutants expressing or lacking defined resistance-nodulation-cell division (RND) efflux pumps using CLSI methodology at pHs of 5.8 and 7.2. Delafloxacin
Sandra P. McCurdy +2 more
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Antibiotics, 2023 The aim of this work was to (i) evaluate the efficacy of a combination treatment of pentamidine with ciprofloxacin against Galleria mellonella larvae infected with an MDR strain of P.
Megan Fletcher +3 more
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Detection of tetracyclines and efflux pump inhibitors [PDF]
Antimicrobial Agents and Chemotherapy, 1993 Screening assays for the detection of tetracyclines and inhibitors of tetracycline efflux pumps are described. The tetracycline assay is based on the observation that the tetA(B) gene encoding the efflux pump of transposon Tn10 is induced by tetracycline.
D M, Rothstein +6 more
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Mechanisms of RND multidrug efflux pumps [PDF]
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2009 RND (Resistance-Nodulation-Division) family transporters are widespread especially among Gram-negative bacteria, and catalyze the active efflux of many antibiotics and chemotherapeutic agents. They have very large periplasmic domains, and form tripartite complexes with outer membrane channels and periplasmic adaptor proteins.
Hiroshi, Nikaido, Yumiko, Takatsuka
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Role of efflux pumps in reduced susceptibility to tigecycline in Acinetobacter baumannii
New Microbes and New Infections, 2019 Acinetobacter baumannii is an important human pathogen responsible for a various type of infections. These bacterial strains are generally resistant to numerous antibiotics.
S.H. Ardehali +5 more
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Number of detected peptides from efflux pumps.
, 2023 Number of detected peptides from efflux pumps.
Holger C. Scholz (9118844) +5 more
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The Role of Efflux Pumps in the Transition from Low-Level to Clinical Antibiotic Resistance
Antibiotics, 2020 Antibiotic resistance is on the rise and has become one of the biggest public health challenges of our time. Bacteria are able to adapt to the selective pressure exerted by antibiotics in numerous ways, including the (over)expression of efflux pumps ...
Anna Elisabeth Ebbensgaard +2 more
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Efflux pump proteins in antifungal resistance [PDF]
Frontiers in Pharmacology, 2014 It is now well-known that the enhanced expression of ATP binding cassette (ABC) and major facilitator superfamily (MFS) proteins contribute to the development of tolerance to antifungals in yeasts. For example, the azole resistant clinical isolates of the opportunistic human fungal pathogen Candida albicans show an overexpression of Cdr1p and/or ...
Prasad, Rajendra, Rawal, Manpreet K.
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Frontiers in Microbiology, 2015 The era of antibiotics as a cure-all for bacterial infections appears to be coming to an end. The emergence of multidrug resistance in many hospital-associated pathogens has resulted in superbugs that are effectively untreatable.
Karl A Hassan +9 more
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