Multidrug Efflux Pumps at the Crossroad between Antibiotic Resistance and Bacterial Virulence [PDF]
Frontiers in Microbiology, 2016 Multidrug efflux pumps can be involved in bacterial resistance to antibiotics at different levels. Some efflux pumps are constitutively expressed at low levels and contribute to intrinsic resistance.
Manuel Alcalde-Rico +2 more
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The Varied Role of Efflux Pumps of the MFS Family in the Interplay of Bacteria with Animal and Plant Cells [PDF]
Microorganisms, 2019 Efflux pumps represent an important and large group of transporter proteins found in all organisms. The importance of efflux pumps resides in their ability to extrude a wide range of antibiotics, resulting in the emergence of multidrug resistance in many
Milena Grossi +2 more
exaly +7 more sources
Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
Frontiers in Microbiology, 2021 Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug
Kunihiko Nishino +2 more
exaly +3 more sources
The putative drug efflux systems of the Bacillus cereus group. [PDF]
PLoS ONE, 2017 The Bacillus cereus group of bacteria includes seven closely related species, three of which, B. anthracis, B. cereus and B. thuringiensis, are pathogens of humans, animals and/or insects.
Karl A Hassan +11 more
doaj +18 more sources
Biofilm Formation and the Role of Efflux Pumps in ESKAPE Pathogens [PDF]
MicroorganismsNosocomial infections caused by ESKAPE pathogens represent a significant burden to global health. These pathogens may exhibit multidrug resistance (MDR) mechanisms, of which mechanisms such as efflux pumps and biofilm formation are gaining significant ...
Trent R. Sorenson +2 more
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Bacterial Multidrug Efflux Pumps: Much More Than Antibiotic Resistance Determinants
Microorganisms, 2016 Bacterial multidrug efflux pumps are antibiotic resistance determinants present in all microorganisms. With few exceptions, they are chromosomally encoded and present a conserved organization both at the genetic and at the protein levels.
Paula Blanco +2 more
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Functional interplay between RND efflux pumps and GacS in Pseudomonas aeruginosa [PDF]
Applied and Environmental MicrobiologyPseudomonas aeruginosa is an opportunistic human pathogen that is ubiquitous in the environment. The environmental versatility of P. aeruginosa is often attributed to a large arsenal of active efflux pumps, low permeability of the outer membrane, and ...
Justyna W. Adamiak +6 more
doaj +2 more sources
Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates [PDF]
Frontiers in MicrobiologyAntibiotic-resistant Gram-negative bacteria are an increasing threat to human health. Strategies to restore antibiotic efficacy include targeting multidrug efflux pumps by competitive efflux pump inhibitors. These could be derived from natural substrates
Léna Mazza +12 more
doaj +2 more sources
Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview
Antibiotics, 2022 Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by decreasing the intracellular concentration of drugs. This protective barrier consists of a series of transporter proteins, which are located in the bacterial ...
Menghong Dai, Haihong Hao, Xu Wang
exaly +3 more sources
Efflux pumps: gatekeepers of antibiotic resistance in Staphylococcus aureus biofilms [PDF]
Microbial CellStaphylococcus aureus, a versatile human pathogen, poses a significant challenge in healthcare settings due to its ability to develop antibiotic resistance and form robust biofilms.
Shweta Sinha +2 more
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