Results 71 to 80 of about 86,304 (284)

Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions [PDF]

, 2016
The expression of polyspecific membrane transporters is one important mechanism by which cells can obtain resistance to structurally different antibiotics and cytotoxic agents.

core   +2 more sources

Indole contributes to tetracycline resistance via the outer membrane protein OmpN in Vibrio splendidus [PDF]

, 2020
As an interspecies and interkingdom signaling molecule, indole has recently received attention for its diverse effects on the physiology of both bacteria and hosts. In this study, indole increased the tetracycline resistance of Vibrio splendidus.
Guo, Ming, Li, Chenghua, Lv, Zhimeng, Shao, Yina, Zhang, Shanshan, Zhang, Weiwei, Zhao, Xuelin   +6 more
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy

Antibiotics, 2023
Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections.
Asiyeh Avakh, Gary D. Grant, Matthew J. Cheesman, Tejaswini Kalkundri, Susan Hall   +4 more
doaj   +1 more source

Raman Microscopy at the Organic–Inorganic Interfaces in Human Calcified Aortic Valves Shows the Co‐Existence of Whitlockite Crystals and Carbonated Hydroxyapatite‐Mineralized Collagen Fibrils

Advanced Functional Materials, EarlyView.
This study advances our understanding of aortic valve stenosis by capturing spatially resolved chemical and structural changes at the nanoscale. The findings highlight the potential of combined Raman and electron microscopy for understanding calcification mechanisms across diverse tissue types.
Robin H. M. Van der Meijden, Carolien T. A Kuster, Amber van Broekhoven, Raphaela Allgayer, Luco Rutten, Rona Roverts, Marta Cerruti, Elena Macías‐Sánchez, Jan Hein Cornel, Salloua el Messaoudi, Anat Akiva, Nico Sommerdijk   +11 more
wiley   +1 more source

Types and Mechanisms of Efflux Pump Systems and the Potential of Efflux Pump Inhibitors in the Restoration of Antimicrobial Susceptibility, with a Special Reference to Acinetobacter baumannii

Pathogens
Bacteria express a plethora of efflux pumps that can transport structurally varied molecules, including antimicrobial agents and antibiotics, out of cells.
Kira M. Zack, Trent Sorenson, Suresh G. Joshi   +2 more
doaj   +1 more source

Global analyses of TetR family transcriptional regulators in mycobacteria indicates conservation across species and diversity in regulated functions [PDF]

, 2015
BACKGROUND: Mycobacteria inhabit diverse niches and display high metabolic versatility. They can colonise both humans and animals and are also able to survive in the environment.
A Mitchell, AA Alatoom, AJ Pompeani, AM McGuire, Ashima Singla, C Cole, D Goeke, F Frenois, F Frenois, G Beckers, J Engohang-Ndong, JA Ibarra, JD Thompson, JE Galagan, JR Bolla, K Rutherford, L Aravind, L Cuthbertson, L Cuthbertson, L Liu, L McMurry, LG Dover, M de la Paz Santangelo, M Weigoldt, MA Behr, MA Schumacher, Mahmudul Hasan Sikder, Mike Withers, MP Santangelo, NK Dutta, NM Nesbitt, P Golby, R Brosch, R Geize Van der, Ricardo J. C. Balhana, RJ Balhana, S Hirano, S Moller, Sharon L. Kendall, SK Ahn, SL Kendall, SL Kendall, TC Galvao, TL Bailey, V Vindal, Z Yu   +45 more
core   +3 more sources

Bacterial efflux pump inhibitors from natural sources [PDF]

Journal of Antimicrobial Chemotherapy, 2006
The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the discovery of new antibacterials and resistance-modifying agents. Since the initial discovery of bacterial efflux pumps in the 1980s, many have been characterized in community- and hospital-acquired Gram-positive and Gram-negative pathogens, such as Staphylococcus ...
Stavri, Michael, Piddock, Laura J. V., Gibbons, Simon   +2 more
openaire   +3 more sources

Meta‐Rod Mechanical Metamaterials With Programmable Reconfiguration

Advanced Functional Materials, EarlyView.
Existing mechanical metamaterials achieve programmable large deformations in planar square or cubic configurations, restricted by required complex boundary conditions. This research proposes a 1D metamaterial, Meta‐rod, with linear, bending, twisting, area, and volume deformation modes.
Atharva Pande, Lyes Kadem, Hang Xu
wiley   +1 more source

RND Efflux Systems Contribute to Resistance and Virulence of Aliarcobacter butzleri

Antibiotics, 2021
Aliarcobacter butzleri is an emergent enteropathogen that can be found in a range of environments. This bacterium presents a vast repertoire of efflux pumps, such as the ones belonging to the resistance nodulation cell division family, which may be ...
Cristiana Mateus, Ana Rita Nunes, Mónica Oleastro, Fernanda Domingues, Susana Ferreira   +4 more
doaj   +1 more source