Results 71 to 80 of about 54,202 (287)
Advanced Functional Materials, EarlyView.Mucoadhesive amphiphilic block and statistical copolymers were synthesized via Reversible Addition–Fragmentation Chain Transfer polymerization from bio‐sourced myrcene and polyethylene glycol methacrylate. The resulting polymers exhibit narrow molar‐mass distributions, high regioselectivity, well‐defined microstructures, and tend to self‐assemble into ...
David Gintsburg +9 more
wiley +1 more source
Structure of the AcrAB–TolC multidrug efflux pump [PDF]
Nature, 2014 The capacity of numerous bacterial species to tolerate antibiotics and other toxic compounds arises in part from the activity of energy-dependent transporters. In Gram-negative bacteria, many of these transporters form multicomponent 'pumps' that span both inner and outer membranes and are driven energetically by a primary or secondary transporter ...
Du, Dijun +8 more
openaire +2 more sources
Multifunctional Bacterial Multi-Drug Efflux Pumps – not just for resistance
, 2006 It is well established that multidrug-resistance efflux pumps encoded by bacteria can confer clinically relevant resistance to antibiotics. It is now understood that these efflux pumps also have a physiological role(s).
Piddock, Laura, Laura J. V. Piddock
core +1 more source
Advanced Healthcare Materials, EarlyView.The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley +1 more source
Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy
Advanced Materials, EarlyView.Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa +3 more
wiley +1 more source
The putative drug efflux systems of the Bacillus cereus group. [PDF]
PLoS ONE, 2017 The Bacillus cereus group of bacteria includes seven closely related species, three of which, B. anthracis, B. cereus and B. thuringiensis, are pathogens of humans, animals and/or insects.
Karl A Hassan +11 more
doaj +1 more source
Mechanism and Interactions of Inner and Outer Membrane Components of RND Efflux Pumps [PDF]
, 2016 Since the discovery of antibiotics, an ongoing race commenced between society’s ability to develop drugs and resistant bacteria. The combat has led to many drug discoveries, but it has also led to different mechanisms of the pathogens to evade cell ...
Ntreh, Abigail
core
Role of Efflux Pumps on Antimicrobial Resistance in Pseudomonas aeruginosa
, 2022 Antimicrobial resistance is an old and silent pandemic. Resistant organisms emerge in parallel with new antibiotics, leading to a major global public health crisis over time.
Felipe Francisco Tuon +9 more
core +1 more source
Advanced Materials, EarlyView.Elephant‐skin‐inspired crack networks are programmed in porous diatomaceous earth (DE)‐cement composites using substrate‐guided, stress‐concentration induced fracture. The resulting crack lattices act as capillary conduits that redistribute water, while the porous matrix stores moisture.
Qingya Huang +5 more
wiley +1 more source
Role of H- and D- MATE-type transporters from multidrug resistant clinical isolates of Vibrio fluvialis in conferring fluoroquinolone resistance. [PDF]
PLoS ONE, 2012 BACKGROUND: The study seeks to understand the role of efflux pumps in multidrug resistance displayed by the clinical isolates of Vibrio fluvialis, a pathogen known to cause cholera-like diarrhoea.
Priyabrata Mohanty +2 more
doaj +1 more source