Results 61 to 70 of about 86,304 (284)

Fighting back against bacterial resistance: Harnessing nanocarrier strategies to counter antibiotic efflux pumps

Next Materials
The global rise of multidrug-resistant (MDR) bacterial infections poses a significant threat to public health, mainly driven by antibiotic efflux pumps that actively expel drugs from bacterial cells and lower intracellular antibiotic concentrations below
Kingsley Chimaeze Mbara, Yvonne Ngcobo, Betty Chivasa, Lethabo Masemola, Refilwe Mashamaite, Kopang Clemendi Mokhetho, Motsi Phuthi, Mandisa Mangisa, Poloko Stephen Kheoane, Shoeshoe Lydia Mokhele, Lorato Mmaoratwe Marakalala, Claudine Mbeb, Rosalinda Pepita Emeyene, Carmen Myrna Leonard, Vuyelwa Jacqueline Tembu, Clemence Tarirai   +15 more
doaj   +1 more source

Beyond Antimicrobial Resistance: Evidence for a Distinct Role of the AcrD Efflux Pump in Salmonella Biology

mBio, 2016
For over 20 years, bacterial multidrug resistance (MDR) efflux pumps have been studied because of their impact on resistance to antimicrobials. However, critical questions remain, including why produce efflux pumps under non-antimicrobial treatment ...
Michelle M. C. Buckner, Jessica M. A. Blair, Roberto M. La Ragione, Jane Newcombe, Daniel J. Dwyer, Alasdair Ivens, Laura J. V. Piddock   +6 more
doaj   +1 more source

Effect of β-lactamase inhibitors on in vitro activity of β-lactam antibiotics against Burkholderia cepacia complex species [PDF]

, 2016
Background: Bacteria belonging to the Burkholderia cepacia complex (Bcc) are an important cause of chronic respiratory tract infections in cystic fibrosis patients. Intrinsic resistance to a wide range of antimicrobial agents, including a variety of beta-
Coenye, Tom, Everaert, Annelien
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2012
Multidrug resistant (MDR) tuberculosis is caused by Mycobacterium tuberculosis resistant to isoniazid and rifampicin, the two most effective drugs used in tuberculosis therapy.
Diana Machado, Isabel Couto, João Perdigão, Liliana Rodrigues, Isabel Portugal, Pedro Baptista, Bruno Veigas, Leonard Amaral, Miguel Viveiros   +8 more
doaj   +1 more source

Microbial Communities of the Providence River [PDF]

, 2015
The Providence River has been industrialized for over one-hundred years. Industries such as oil storage and metal recycling facilities have left high levels of pollutant metals, including lead (Pb), in the soil and water.
Kratch, Jacqueline
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Clinical Status of Efflux Resistance Mechanisms in Gram-Negative Bacteria

Antibiotics, 2021
Antibiotic efflux is a mechanism that is well-documented in the phenotype of multidrug resistance in bacteria. Efflux is considered as an early facilitating mechanism in the bacterial adaptation face to the concentration of antibiotics at the infectious ...
Anne Davin-Regli, Jean-Marie Pages, Aurélie Ferrand   +2 more
doaj   +1 more source

Dynamic energy budget approach to evaluate antibiotic effects on biofilms [PDF]

, 2017
Quantifying the action of antibiotics on biofilms is essential to devise therapies against chronic infections. Biofilms are bacterial communities attached to moist surfaces, sheltered from external aggressions by a polymeric matrix.
Birnir, Bjorn, Carpio, Ana, Cebrian, Elena, Vidal, Perfecto   +3 more
core   +3 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source