Results 111 to 120 of about 4,990,704 (352)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Europe's Journal of Psychology, 2012 This study examined the structural relationships among cognitive constructs (intelligence and achievement) and affective constructs (perceived parental help, effort and self-concept). It was proposed that the relationships are not invariant across gender.
Maher Abu-Hilal, Intisar Nasser
doaj +1 more source
Vigor of reaching movements: reward discounts the cost of effort.
Journal of Neurophysiology, 2018 Making a movement may be thought of as an economic decision in which one spends effort to acquire reward. Time discounts reward, which predicts that the magnitude of reward should affect movement vigor: we should move faster, spending greater effort ...
Erik M. Summerside +2 more
semanticscholar +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Welfare Costs of Sticky Wages When Effort Can Respond [PDF]
We examine the impact of wage stickiness when employment has an effort as well as hours dimension. Despite wages being predetermined, the labor market clears through the effort margin.
Mark Bils, Yongsung Chang
core
A specific role for serotonin in overcoming effort cost
eLife, 2016 Serotonin is implicated in many aspects of behavioral regulation. Theoretical attempts to unify the multiple roles assigned to serotonin proposed that it regulates the impact of costs, such as delay or punishment, on action selection.
Florent Meyniel +8 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Effort and comparison income: experimental and survey evidence [PDF]
The authors test the hypothesis that individual effort on the job depends both on one's own income and on the individual's position in the relevant income distribution.
Marie-Claire Villeval +2 more
core
Brazilian Journal of BiologyNestedness, the pattern in which the species of a species-poor community are a subset of species-rich communities, can provide information regarding species order of extinction, which is vital knowledge for conservation biology.
JFS. Menezes, FAS. Fernandez
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source