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Preclinical Evaluation of the Efficacy of α-Difluoromethylornithine and Sulindac Against SARS-CoV-2 Infection. [PDF]
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Journal of the Dermatology Nurses' Association, 2021
ABSTRACT Drugs are substances that exert effects in the body in order to alter an existing physiological or biochemical process. There are several methods of administering drugs, including the use of creams, ointments, liquids, skin patches, capsules, and injections.
Ana Carolina Chen, Janiene D. Luke
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ABSTRACT Drugs are substances that exert effects in the body in order to alter an existing physiological or biochemical process. There are several methods of administering drugs, including the use of creams, ointments, liquids, skin patches, capsules, and injections.
Ana Carolina Chen, Janiene D. Luke
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American Journal of Clinical Dermatology, 2001
Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase which is thought to slow hair growth by inhibiting this enzyme in hair follicles. Percutaneous absorption of eflornithine in women with unwanted facial hair (hirsutism) was < 1% when the 15% cream was applied twice daily to a shaved 50 cm2 area of skin under the ...
J A, Balfour, K, McClellan
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Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase which is thought to slow hair growth by inhibiting this enzyme in hair follicles. Percutaneous absorption of eflornithine in women with unwanted facial hair (hirsutism) was < 1% when the 15% cream was applied twice daily to a shaved 50 cm2 area of skin under the ...
J A, Balfour, K, McClellan
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Pharmaceutisch Weekblad, 1989
Eflornithine (alpha-difluoromethylornithine; DFMO) is a recently developed drug against African trypanosomiasis (sleeping sickness). After a short description of trypanosomiasis and the current treatment, the mechanism of action of eflornithine is discussed, some clinical data is given and attention is paid to recently discovered analogues of ...
I, Van Bogaert, A, Haemers
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Eflornithine (alpha-difluoromethylornithine; DFMO) is a recently developed drug against African trypanosomiasis (sleeping sickness). After a short description of trypanosomiasis and the current treatment, the mechanism of action of eflornithine is discussed, some clinical data is given and attention is paid to recently discovered analogues of ...
I, Van Bogaert, A, Haemers
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Treatment of Recurrent Gliomas With Eflornithine
JNCI Journal of the National Cancer Institute, 1992Oral eflornithine in combination with intravenous mitoguazone (methylbisguanylhydrazone) has shown activity against recurrent anaplastic gliomas. Eflornithine alone, however, has not been evaluated against recurrent gliomas.This study compared the antitumor activity of oral eflornithine with that of oral eflornithine combined with intravenous ...
V A, Levin +5 more
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Eflornithine for the treatment of human African trypanosomiasis
Parasitology Research, 2003Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. The most commonly used dosage regimen for the treatment of T. b.
Christian, Burri, Reto, Brun
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Late-Stage African Trypanosomiasis and Eflornithine
Annals of Internal Medicine, 1986Excerpt To the editor: Human trypanosomiasis is a major public health problem in many African countries. At present, there is alarm at the recrudescence of this disease in its historical habitats.
CESARE DI BARI +4 more
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