Results 1 to 10 of about 1,217 (167)

EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways [PDF]

Advanced Science
Elongation Factor Tu GTP‐Binding Domain Containing 2 (EFTUD2), a core spliceosomal GTPase associated with Mandibulofacial Dysostosis with Microcephaly (MFDM), plays a mechanistically undefined role in cerebral development.
Liping Chen, Ying Li, Yan Yu, Mingze Cai, Hao Li, Minghe Huang, Guochao Yang, Jiageng Guo, Huailin Wang, Zhihong Song, Wei Shen, Huihui Jiang, Haitao Wu   +12 more
doaj   +7 more sources

EFTUD2 is a promising diagnostic and prognostic indicator involved in the tumor immune microenvironment and glycolysis of lung adenocarcinoma [PDF]

Frontiers in Oncology
BackgroundElongation Factor Tu GTP Binding Domain Containing 2 (EFTUD2), a conserved spliceosomal GTPase, is involved in craniofacial development and various cancers, but its role in lung adenocarcinoma (LUAD) remains unclear.MethodsEFTUD2 expression in ...
Yufan Xu
exaly   +8 more sources

The Spliceosome Factor EFTUD2 Promotes IFN Anti-HBV Effect through mRNA Splicing [PDF]

Mediators of Inflammation, 2023
Background/Aims. The underlying mechanisms of differential responsiveness to IFN remain poorly understood. The elongation factor Tu GTP binding domain-containing protein 2 (EFTUD2), involved in RNA splicing and pre-mRNA processing, was recognized as a ...
Pingping Hu, Yuwen Li, Wen Zhang, Rui Liu, Linya Peng, Ruirui Xu, Jinyuan Cai, Hui Yuan, Tiantong Feng, Anran Tian, Ming Yue, Jun Li, Wenting Li, Chuanlong Zhu   +13 more
doaj   +5 more sources

Interaction of Newcastle disease virus V protein with EFTUD2 modulates MDA5 pathway to suppress viral replication [PDF]

Poultry Science
Elongation factor Tu GTP-binding domain-containing protein 2 (EFTUD2), a core component of U5 small nuclear ribonucleoprotein particles (snRNPs), recently emerged as a novel innate immune regulator.
Yin Han, Fan Zhang, Ziqing Zhou, Yufang Huang, Ruiai Chen   +4 more
doaj   +5 more sources

The Core Splicing Factors EFTUD2, SNRPB and TXNL4A Are Essential for Neural Crest and Craniofacial Development

Journal of Developmental Biology, 2022
Mandibulofacial dysostosis (MFD) is a human congenital disorder characterized by hypoplastic neural-crest-derived craniofacial bones often associated with outer and middle ear defects.
Byung-Yong Park, Jean-Pierre Saint-Jeannet, Chibuike J N Ihewulezi   +2 more
exaly   +6 more sources

LncRNA CA13/EFTUD2/CA13 caused crossed beak by regulating the mandibular calcification in chicken [PDF]

Poultry Science
Crossed beak is a beak deformity that reduces feeding and drinking in affected chickens, thereby diminishing chicken production performance. Previous studies have shown that long non-coding RNA CA13 (lncRNA CA13), as an upstream regulator of carbonic ...
Min Wu, Dan Su, Xinxin Li, Junjie Xu, Yihao Fan, Xinglin Wu, Xuelu Liu, Bofei Su, Dehe Wang, Yifan Chen, Erying Hao, Hao Bai, Hui Chen, Jilan Chen, Lei Shi   +14 more
doaj   +4 more sources

The feedback loop of EFTUD2/c-MYC impedes chemotherapeutic efficacy by enhancing EFTUD2 transcription and stabilizing c-MYC protein in colorectal cancer [PDF]

Journal of Experimental & Clinical Cancer Research
Background Chemoresistance presents a significant obstacle in the treatment of colorectal cancer (CRC), yet the molecular basis underlying CRC chemoresistance remains poorly understood, impeding the development of new therapeutic interventions ...
Xiaojian Zhu, Changxue Li, Yunfei Gao, Qingyuan Zhang, Tao Wang, Huaixiang Zhou, Fanqin Bu, Jia Chen, Xinjun Mao, Yulong He, Kaiming Wu, Ningning Li, Hongliang Luo   +12 more
doaj   +4 more sources

Loss of function mutation of Eftud2, the gene responsible for mandibulofacial dysostosis with microcephaly (MFDM), leads to pre-implantation arrest in mouse

PLoS ONE, 2019
Mutations in EFTUD2 are responsible for the autosomal dominant syndrome named MFDM (mandibulofacial dysostosis with microcephaly). However, it is not clear how reduced levels of EFTUD2 cause abnormalities associated with this syndrome.
Loydie Anne Jerome-Majewska, Anissa Djedid, Jacek Majewski   +2 more
exaly   +3 more sources

Recurrent mandibulofacial dysostosis, Guion-Almeida type in consecutive pregnancies due to maternal mosaicism of a novel EFTUD2 variant: a case report and review of the literature [PDF]

Journal of Medical Case Reports
Background Mandibulofacial dysostosis, Guion-Almeida type is an autosomal dominant disorder characterized by craniofacial malformations and intellectual disability.
Bing Wang, Chunxiao Hua, Qimeng Liu, Dajun Cai   +3 more
doaj   +2 more sources

Addressing the tissue specificity of U5 snRNP spliceosomopathies [PDF]

Frontiers in Cell and Developmental Biology
Precursor mRNA (pre-mRNA) must undergo splicing to remove intron sequences and join exons. This splicing process is catalysed by an RNA/protein complex called the spliceosome.
Rahmat Azhari Kemal, Rahmat Azhari Kemal, Raymond T. O’Keefe   +2 more
doaj   +2 more sources