EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways [PDF]
Advanced ScienceElongation Factor Tu GTP‐Binding Domain Containing 2 (EFTUD2), a core spliceosomal GTPase associated with Mandibulofacial Dysostosis with Microcephaly (MFDM), plays a mechanistically undefined role in cerebral development.
Liping Chen +12 more
doaj +3 more sources
EFTUD2 is a promising diagnostic and prognostic indicator involved in the tumor immune microenvironment and glycolysis of lung adenocarcinoma [PDF]
Frontiers in OncologyBackgroundElongation Factor Tu GTP Binding Domain Containing 2 (EFTUD2), a conserved spliceosomal GTPase, is involved in craniofacial development and various cancers, but its role in lung adenocarcinoma (LUAD) remains unclear.MethodsEFTUD2 expression in ...
Zebin Zhang, Guoxiang Fu, Zhang Zebin
exaly +4 more sources
Spliceosomal GTPase Eftud2 regulates microglial activation and polarization [PDF]
Neural Regeneration Research, 2023 Elongation factor Tu GTP binding domain protein 2 (Eftud2) is a spliceosomal GTPase that serves as an innate immune modulator restricting virus infection.
Haitao Wu
exaly +4 more sources
Interaction of Newcastle disease virus V protein with EFTUD2 modulates MDA5 pathway to suppress viral replication [PDF]
Poultry ScienceElongation factor Tu GTP-binding domain-containing protein 2 (EFTUD2), a core component of U5 small nuclear ribonucleoprotein particles (snRNPs), recently emerged as a novel innate immune regulator.
Yin Han +4 more
doaj +2 more sources
The Spliceosome Factor EFTUD2 Promotes IFN Anti-HBV Effect through mRNA Splicing [PDF]
Mediators of Inflammation, 2023 Background/Aims. The underlying mechanisms of differential responsiveness to IFN remain poorly understood. The elongation factor Tu GTP binding domain-containing protein 2 (EFTUD2), involved in RNA splicing and pre-mRNA processing, was recognized as a ...
Pingping Hu +13 more
doaj +2 more sources
Journal of Developmental Biology, 2022 Mandibulofacial dysostosis (MFD) is a human congenital disorder characterized by hypoplastic neural-crest-derived craniofacial bones often associated with outer and middle ear defects.
Byung-Yong Park +2 more
exaly +3 more sources
LncRNA CA13/EFTUD2/CA13 caused crossed beak by regulating the mandibular calcification in chicken [PDF]
Poultry ScienceCrossed beak is a beak deformity that reduces feeding and drinking in affected chickens, thereby diminishing chicken production performance. Previous studies have shown that long non-coding RNA CA13 (lncRNA CA13), as an upstream regulator of carbonic ...
Min Wu +14 more
doaj +2 more sources
Recurrent mandibulofacial dysostosis, Guion-Almeida type in consecutive pregnancies due to maternal mosaicism of a novel EFTUD2 variant: a case report and review of the literature [PDF]
Journal of Medical Case ReportsBackground Mandibulofacial dysostosis, Guion-Almeida type is an autosomal dominant disorder characterized by craniofacial malformations and intellectual disability.
Bing Wang +3 more
doaj +2 more sources
The feedback loop of EFTUD2/c-MYC impedes chemotherapeutic efficacy by enhancing EFTUD2 transcription and stabilizing c-MYC protein in colorectal cancer [PDF]
Journal of Experimental & Clinical Cancer ResearchBackground Chemoresistance presents a significant obstacle in the treatment of colorectal cancer (CRC), yet the molecular basis underlying CRC chemoresistance remains poorly understood, impeding the development of new therapeutic interventions ...
Xiaojian Zhu +12 more
doaj +2 more sources
Addressing the tissue specificity of U5 snRNP spliceosomopathies [PDF]
Frontiers in Cell and Developmental BiologyPrecursor mRNA (pre-mRNA) must undergo splicing to remove intron sequences and join exons. This splicing process is catalysed by an RNA/protein complex called the spliceosome.
Rahmat Azhari Kemal +2 more
doaj +2 more sources