Results 101 to 110 of about 1,902 (167)
Advanced Science, Volume 12, Issue 13, April 3, 2025.HCETSR, derived from tRNA‐Glu/TTC, binds to SPTBN1, promoting the dissociation of SPTBN1 from the catenin complex and facilitating the translocation of the catenin complex from the cell membrane to the nucleus. Meanwhile, HCETSR reduces proteasomal degradation of β‐catenin and synthesis of nascent β‐catenin.
Tao Rui +13 more
wiley +1 more source
Long non-coding RNA SENCR is a positive regulator of ETV2 [PDF]
, 2017 Department of Biological SciencesAlthough long non-coding RNAs (lncRNAs) have emerged as novel regulator of cell fate and gene expression, the regulation of vascular specific transcription factor by lncRNA in generation of induced endothelial cells ...
Jeong, Yujin
core
Advanced Science, Volume 12, Issue 12, March 27, 2025.Targeting mesothelin (MSLN) improved neoantigen vaccine efficacy in pancreatic cancer by reducing apCAFs, which disrupted the conversion of naive CD4+ T cells into Tregs and enhanced the infiltration of IFN‐γ+CD4+ and GZMK+CD8+ T cells. This combination strengthened neoantigen‐specific T cell response to overcome the immunosuppressive tumor ...
Zhixiong Cai +11 more
wiley +1 more source
Understanding GEMIN5 Interactions: From Structural and Functional Insights to Selective Translation
WIREs RNA, Volume 16, Issue 2, March/April 2025.GEMIN5 structural domains. Overview of GEMIN5's role in snRNP assembly and translation regulatory events. ABSTRACT GEMIN5 is a predominantly cytoplasmic protein, initially identified as a member of the survival of motor neurons (SMN) complex. In addition, this abundant protein modulates diverse aspects of RNA‐dependent processes, executing its ...
Encarnacion Martinez‐Salas +2 more
wiley +1 more source
Molecular Genetics &Genomic Medicine, Volume 13, Issue 1, January 2025.ABSTRACT Background Chromosome 3q29 duplication syndrome is a rare chromosomal disorder with a frequency of 1:5000 in patients with a neurodevelopmental phenotype. The syndrome is characterized by phenotypic polymorphism and reduced penetrance. Methods Patients were investigated by performing a cytogenetic analysis of GTG‐banded metaphases, aCGH with ...
A. A. Kashevarova +16 more
wiley +1 more source
Identifying biological pathways that underlie primordial short stature using network analysis [PDF]
, 2014 Mutations in CUL7, OBSL1 and CCDC8, leading to disordered ubiquitination, cause one of the commonest primordial growth disorders, 3-M syndrome. This condition is associated with i) abnormal p53 function, ii) GH and/or IGF1 resistance, which may relate to
Black, Graeme C M +4 more
core +1 more source
Inhibition of SNW1 association with spliceosomal proteins promotes apoptosis in breast cancer cells [PDF]
, 2015 名古屋大学Nagoya University博士(医学)doctoral ...
58790 +3 more
core
Identification of Novel Oncogenes Activated by Enhancer Hijacking [PDF]
Genome instability is a hallmark of cancer, resulting in the accumulation of various types of alterations. Somatic structural variations (SVs) in cancer can shuffle DNA content in the genome, relocate regulatory elements, and alter genome organization ...
Yu, Anqi
core +1 more source
Taiwanese Journal of Obstetrics & GynecologyObjective: To assess the combined role of prenatal imaging and stepwise genetic testing in diagnosing fetal congenital heart defects (CHDs) over a 30-year period, focusing on CHD subtypes, extracardiac anomalies, and diagnostic yield.
Jenn-Jhy Tseng, Shen-Ling Jan
doaj +1 more source
Prenatal Ultrasound and Genetic Diagnosis of EFTUD2 Haploinsufficiency in Two Fetuses: A Case Series
The Application of Clinical GeneticsAgata Kucińska,1 Lech Dudarewicz,1 Beata Anna Nowakowska,2 Maciej Geremek,2 Urszula Wysocka,1 Łukasz Przesór,1 Dobromiła Barańska,3 Piotr Grzelak,3 Agnieszka Gach1 1Department of Genetics, Polish Mother’s ...
Kucińska A +8 more
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