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Biochemical Pharmacology, 2021 International audienceEg5, the product of Kif11 gene, also known as kinesin spindle protein, is a motor protein involved in the proper establishment of a bipolar mitotic spindle.
Isabel García-Sáez +1 more
exaly +2 more sources
The structure of the ternary Eg5–ADP–ispinesib complex [PDF]
Acta Crystallographica Section D: Biological Crystallography, 2012 The human kinesin Eg5 is responsible for bipolar spindle formation during early mitosis. Inhibition of Eg5 triggers the formation of monoastral spindles, leading to mitotic arrest that eventually causes apoptosis.
Talapatra, S.K. +2 more
exaly +2 more sources
New chemical tools for investigating human mitotic kinesin Eg5
Bioorganic and Medicinal Chemistry, 2007 We have designed and synthesized a series of monastrol derivatives, an allosteric inhibitor of Eg5, a motor protein responsible for the formation and maintenance of the bipolar spindle in mitotic cells.
Emmanuel Klein +2 more
exaly +2 more sources
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Eg5 as a Prognostic Biomarker and Potential Therapeutic Target for Hepatocellular Carcinoma
Cells, 2021Yu-Yun Shao +2 more
exaly