Involvement of C-terminal truncation mutation of kinesin-5 in resistance to kinesin-5 inhibitor. [PDF]
PLoS ONE, 2018 Cultured cells easily develop resistance to kinesin-5 inhibitors (K5Is) often by overexpressing a related motor protein, kinesin-12/KIF15, or by acquiring mutations in the N-terminal motor domain of kinesin-5/KIF11 itself.
Eri Saeki +6 more
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Correction: Involvement of C-terminal truncation mutation of kinesin-5 in resistance to kinesin-5 inhibitor. [PDF]
PLoS ONE, 2019 [This corrects the article DOI: 10.1371/journal.pone.0209296.].
Eri Saeki +6 more
doaj +4 more sources
Kinesin-5 inhibition improves neural regeneration in experimental autoimmune neuritis [PDF]
Journal of Neuroinflammation, 2023 Background Autoimmune neuropathies can result in long-term disability and incomplete recovery, despite adequate first-line therapy. Kinesin-5 inhibition was shown to accelerate neurite outgrowth in different preclinical studies.
Felix Kohle +9 more
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Plasmodium berghei Kinesin-5 Associates With the Spindle Apparatus During Cell Division and Is Important for Efficient Production of Infectious Sporozoites [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 Kinesin-5 motors play essential roles in spindle apparatus assembly during cell division, by generating forces to establish and maintain the spindle bipolarity essential for proper chromosome segregation.
Mohammad Zeeshan +5 more
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Intracellular functions and motile properties of bi-directional kinesin-5 Cin8 are regulated by neck linker docking [PDF]
eLife, 2021 In this study, we analyzed intracellular functions and motile properties of neck-linker (NL) variants of the bi-directional S. cerevisiae kinesin-5 motor, Cin8. We also examined – by modeling – the configuration of H-bonds during NL docking.
Alina Goldstein-Levitin +4 more
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How Essential Kinesin-5 Becomes Non-Essential in Fission Yeast: Force Balance and Microtubule Dynamics Matter [PDF]
Cells, 2020 The bipolar mitotic spindle drives accurate chromosome segregation by capturing the kinetochore and pulling each set of sister chromatids to the opposite poles.
Masashi Yukawa +2 more
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Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development [PDF]
Cell Death Discovery, 2022 Chromosome stability relies on bipolar spindle assembly and faithful chromosome segregation during cell division. Kinesin-5 Eg5 is a plus-end-directed kinesin motor protein, which is essential for spindle pole separation and chromosome alignment in ...
Wen-Xin Yu +6 more
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Kinesin-5 Is Dispensable for Bipolar Spindle Formation and Elongation in
mSphere, 2019 Mitotic spindles assume a bipolar architecture through the concerted actions of microtubules, motors, and cross-linking proteins. In most eukaryotes, kinesin-5 motors are essential to this process, and cells will fail to form a bipolar spindle without ...
Irsa Shoukat +2 more
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Kinesin-5 is a microtubule polymerase. [PDF]
Nat Commun, 2015 AbstractKinesin-5 slides antiparallel microtubules during spindle assembly, and regulates the branching of growing axons. Besides the mechanical activities enabled by its tetrameric configuration, the specific motor properties of kinesin-5 that underlie its cellular function remain unclear.
Chen Y, Hancock WO.
europepmc +4 more sources
A 'molecular guillotine' reveals the interphase function of Kinesin-5. [PDF]
J Cell Sci, 2018 Abstract Motor proteins are important for transport and force generation in a variety of cellular processes and morphogenesis. Here we design a general strategy for conditional motor mutants by inserting a protease cleavage site at the “neck” between the head domain and the stalk of the motor protein, making the protein susceptible to ...
Lv Z +3 more
europepmc +4 more sources