Results 1 to 10 of about 3,049 (133)
Development of Styryl-Modified 3,4-Dihydropyrimidin-2(1H)-ones as Potential Antitumor Agents. [PDF]
ChemMedChemStyryl‐modified 3,4‐dihydropyrimidin‐2(1H)‐ones (DHPMs), designed from the Eg5 inhibitor monastrol, show markedly enhanced antiproliferative activity in HeLa and MCF‐7 cancer cells. Lead compounds 16 and 17 trigger apoptosis through cell‐line‐specific pathways and downregulate c‐Myc, emerging as promising anticancer candidates.
Panagoulias K +10 more
europepmc +2 more sources
Insights into the Molecular Mechanisms of Eg5 Inhibition by (+)-Morelloflavone
Pharmaceuticals, 2019 (+)-Morelloflavone (MF) is an antitumor biflavonoid that is found in the Garcinia species. Recently, we reported MF as a novel inhibitor of ATPase and microtubules-gliding activities of the kinesin spindle protein (Eg5) in vitro.
Tomisin Happy Ogunwa +2 more
exaly +3 more sources
The NLS3 Motif in TPX2 Regulates Spindle Architecture in Xenopus Egg Extracts. [PDF]
Cytoskeleton (Hoboken)ABSTRACT A bipolar spindle composed of microtubules and many associated proteins functions to segregate chromosomes during cell division in all eukaryotes, yet both spindle size and architecture vary dramatically across different species and cell types.
Pena GE +4 more
europepmc +2 more sources
Eg5 and Diseases: From the Well-Known Role in Cancer to the Less-Known Activity in Noncancerous Pathological Conditions [PDF]
Biochemistry Research InternationalEg5 is a protein encoded by KIF11 gene and is primarily involved in correct mitotic cell division. It is also involved in nonmitotic processes such as polypeptide synthesis, protein transport, and angiogenesis.
Alessia Ricci +3 more
doaj +2 more sources
Eg5 UFMylation promotes spindle organization during mitosis [PDF]
Cell Death and DiseaseUFMylation is a highly conserved ubiquitin-like post-translational modification that catalyzes the covalent linkage of UFM1 to its target proteins. This modification plays a critical role in the maintenance of endoplasmic reticulum proteostasis, DNA ...
Guangxu Li +9 more
doaj +2 more sources
Aryl-Substituted Dihydro-Pyrimidines Effecting Kinesin Eg5 as Novel Approach for Cancer Treatment [PDF]
MoleculesCancer is one of the most lethal diseases of this century. Unfortunately, many anticancer agents have harsh side effects or fail to work against cancer any longer due to tolerance.
Dialekti Chlorou, Eleni Pontiki
doaj +2 more sources
Frontiers in Oncology, 2022 Tumor necrosis factor receptor associated factor 4 (TRAF4) is a RING domain E3 ubiquitin ligase that mediates the ubiquitination of various proteins and plays an important role in driving tumor progression.
Miaomiao Hao +9 more
doaj +1 more source
Frontiers in Oncology, 2022 The mitotic kinesin Eg5 has emerged as a potential anti-mitotic target for the purposes of cancer chemotherapy. Whether clinical resistance to these inhibitors can arise is unclear.
Rose-Laure Indorato +3 more
doaj +1 more source
Eg5 as a Prognostic Biomarker and Potential Therapeutic Target for Hepatocellular Carcinoma
Cells, 2021 Background: The kinesin Eg5, a mitosis-associated protein, is overexpressed in many cancers. Here we explored the clinical significance of Eg5 in hepatocellular carcinoma (HCC). Methods: HCC tissues from surgical resection were collected.
Yu-Yun Shao +8 more
doaj +1 more source
Tourism as a driver of economic and social development in underdeveloped regions
Regional Science Policy &Practice, EarlyView., 2023 Abstract Cross‐border cooperations have been usually approached by developing trade agreements between international regions to upgrade their socioeconomic conditions and promote international tourism flows in territories. However, little attention has been paid to the role that tourist companies play in underprivileged territories highly dependent on ...
Rafael Robina‐Ramírez +3 more
wiley +1 more source