Results 21 to 30 of about 3,876 (171)

Khám phá các phân tử thuốc từ cơ sở dữ liệu Drugbank như là hợp chất ức chế Kinesin Eg5 ở người bằng docking phân tử

Tạp chí Khoa học Đại học Cần Thơ, 2022
Kinesin Eg5 đóng một vai trò quan trọng trong giai đoạn đầu của quá trình nguyên phân và là một mục tiêu thú vị để thiết kế các loại chất ức chế. Trong nghiên cứu này, sự kết hợp giữa mô hình nghiên cứu 2D-QSAR và docking  phân tử đã được thực hiện trên
Nguyễn Ngọc Lê, Nguyễn Cường Quốc, Trần Quang Đệ   +2 more
doaj   +1 more source

Overexpression of the NEK9–EG5 axis is a novel metastatic marker in pathologic stage T3 colon cancer

Scientific Reports, 2023
NEK9 is a key player in the NEK9–EG5 axis for microtubule polymerization, chromosome alignment, and mitosis. In present study, we investigated the altered expression of the NEK9, EG5 and acetyl-α-tubulin as well as common epithelial–mesenchymal ...
Meejeong Kim, Hui Jeong Jeong, Hyun-min Ju, Ji-young Song, Se Jin Jang, Jene Choi   +5 more
doaj   +1 more source

The kinesin-12 Kif15 is a processive track-switching tetramer [PDF]

, 2014
Kinesin-12 motors are a little studied branch of the kinesin superfamily with the human protein (Kif15) implicated in spindle mechanics and chromosome movement.
McHugh, Toni, Singleton, Martin R., Carter, Nicholas J., Toni McHugh, Hauke Drechsler, Nicholas J Carter, Drechsler, Hauke, McAinsh, Andrew D., Martin R Singleton, Andrew D McAinsh   +9 more
core   +1 more source

Negative Modulation of the Angiogenic Cascade Induced by Allosteric Kinesin Eg5 Inhibitors in a Gastric Adenocarcinoma In Vitro Model

Molecules, 2022
Eg5 is a kinesin essential in bipolar spindle formation, overexpressed in tumours, thus representing a new target in cancer therapy. We aimed at evaluating the anti-cancer activity of Eg5 thiadiazoline inhibitors 2 and 41 on gastric adenocarcinoma cells (
Alessia Ricci, Marialucia Gallorini, Donatella Del Bufalo, Amelia Cataldi, Ilaria D’Agostino, Simone Carradori, Susi Zara   +6 more
doaj   +1 more source

Solvothermal Synthesis of Multiple Dihydropyrimidinones at a Time as Inhibitors of Eg5

Molecules, 2021
Solvothermal synthesis of multiple dihydropyrimidinones at a time has been developed in inexpensive and green bio-based solvent lactic acid without any additional catalysts or additives.
Xiao-Qiang Jiang, Shi-Quan Chen, Yan-Fei Liu, Xin-Guang Pan, Dan Chen, Shi-Fan Wang   +5 more
doaj   +1 more source

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors

Cell Reports, 2015
Novel therapeutic approaches are urgently required for multiple myeloma (MM). We used a phenotypic screening approach using co-cultures of MM cells with bone marrow stromal cells to identify compounds that overcome stromal resistance.
Shrikanta Chattopadhyay, Alison L. Stewart, Siddhartha Mukherjee, Cherrie Huang, Kimberly A. Hartwell, Peter G. Miller, Radhika Subramanian, Leigh C. Carmody, Rushdia Z. Yusuf, David B. Sykes, Joshiawa Paulk, Amedeo Vetere, Sonia Vallet, Loredana Santo, Diana D. Cirstea, Teru Hideshima, Vlado Dančík, Max M. Majireck, Mahmud M. Hussain, Shambhavi Singh, Ryan Quiroz, Jonathan Iaconelli, Rakesh Karmacharya, Nicola J. Tolliday, Paul A. Clemons, Malcolm A.S. Moore, Andrew M. Stern, Alykhan F. Shamji, Benjamin L. Ebert, Todd R. Golub, Noopur S. Raje, David T. Scadden, Stuart L. Schreiber   +32 more
doaj   +1 more source

The Functional Antagonism between Eg5 and Dynein in Spindle Bipolarization Is Not Compatible with a Simple Push-Pull Model

Cell Reports, 2012
During cell division, the molecular motor Eg5 crosslinks overlapping antiparallel microtubules and pushes them apart to separate mitotic spindle poles. Dynein has been proposed as a direct antagonist of Eg5 at the spindle equator, pulling on antiparallel
Stefan Florian, Thomas U. Mayer
doaj   +1 more source

ProHSO4: An efficient catalyst for solvent-free synthesis of bis(indolyl)methanes and their in silico screening for potential biological activity

Results in Chemistry, 2023
A simple, mild, and efficient protocol has been developed for the synthesis of 3,3′-bis(indolyl)methanes (BIMs) using prolinium hydrogen sulfate (ProHSO4) as a catalyst under solvent-free and support-free conditions. This mechanochemical method undergoes
Vikrant Kumbhar, Rutik Raskar, Radha Chafle, Vandana Nikam, Avinash Kumbhar, Ramdas Pawar, Manohar Chaskar, Gulab Gugale, Bhushan Khairnar   +8 more
doaj   +1 more source

Effect of Expanded Graphite on Mechanical and Tribological Properties of Polyamide 6/Glass Fibre Composites

Advances in Polymer Technology, 2022
The quality of plastic gears, especially their durability, is becoming increasingly important due to advances in electric mobility. Therefore, new materials are being developed that must have better mechanical properties, high thermal conductivity for ...
Dajana Japić, Simon Kulovec, Mitjan Kalin, Janez Slapnik, Blaž Nardin, Miroslav Huskić   +5 more
doaj   +1 more source

Eg5 orchestrates porcine oocyte maturational progression by maintaining meiotic organelle arrangement

Cell Division, 2018
Background Kinesin superfamily proteins are microtubule-based molecular motors essential for the intracellular transport of various cargos, including organelles, proteins, and RNAs. However, their exact roles during mammalian oocyte meiosis have not been
Yan Xie, Minghui Cheng, Shan Lu, Qilong Yuan, Dongyu Yang, Ying Chen, Chen Pan, Yurong Qiu, Bo Xiong   +8 more
doaj   +1 more source