Results 11 to 20 of about 3,876 (171)
Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression
Scientific Reports, 2017 EG5 (KIF11) is a member of the kinesin-like protein family involved in centrosome separation and bipolar spindle formation. When a cell enters mitosis, CDK1 phosphorylates EG5 at Thr926 and promotes EG5 localization on the mitotic spindle which drives ...
Yang Liu +9 more
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Fbxo30 Regulates Mammopoiesis by Targeting the Bipolar Mitotic Kinesin Eg5
Cell Reports, 2016 Fbxo30 is an orphan member of the F-box protein family with no known substrate or function. Here we report that, while Fbxo30−/− mice exhibit normal development, growth, lifespan, and fertility, the females fail to nurture their offspring as a result of ...
Yan Liu +5 more
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Cell Division, 2006 Understanding how molecular motors generate force and move microtubules in mitosis is essential to understanding the physical mechanism of cell division.
Fordyce Polly M +2 more
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Dual pathway spindle assembly increases both the speed and the fidelity of mitosis [PDF]
Biology Open, 2011 Summary Roughly half of all animal somatic cell spindles assemble by the classical prophase pathway, in which the centrosomes separate ahead of nuclear envelope breakdown (NEBD).
Kuniyoshi Kaseda +2 more
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Computational and Structural Biotechnology Journal, 2022 Kinesins are microtubule-based motor proteins that play important roles ranging from intracellular transport to cell division. Human Kinesin-5 (Eg5) is essential for mitotic spindle assembly during cell division.
Wenhan Guo +9 more
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Cell Death Discovery, 2022 Chromosome stability relies on bipolar spindle assembly and faithful chromosome segregation during cell division. Kinesin-5 Eg5 is a plus-end-directed kinesin motor protein, which is essential for spindle pole separation and chromosome alignment in ...
Wen-Xin Yu +6 more
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Kinesin-5 Eg5 is essential for spindle assembly and chromosome alignment of mouse spermatocytes
Cell Division, 2020 Background Microtubule organization is essential for bipolar spindle assembly and chromosome segregation, which contribute to genome stability. Kinesin-5 Eg5 is known to be a crucial regulator in centrosome separation and spindle assembly in mammalian ...
Zhen-Yu She +7 more
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Results in Chemistry, 2023 Breast cancer and gliobalstoma are the most aggressive types of diseases causing serious health issues. Potent anticancer molecules are facing serious side effects which arouse the need for newer molecules with significant clinical efficacy and safety ...
Dhirajkumar Nikam, Anurekha Jain
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Fermentation, 2023 Thermophilic endoglucanases have become of significant interest for effectively catalyzing the hydrolysis of cellulose. Myceliophthora thermophila is an ideal source of thermophilic enzymes.
Wenyuan Zhou +5 more
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Phosphorylation by Cdk1 increases the binding of Eg5 to microtubules in vitro and in Xenopus egg extract spindles. [PDF]
PLoS ONE, 2008 BACKGROUND:Motor proteins from the kinesin-5 subfamily play an essential role in spindle assembly during cell division of most organisms. These motors crosslink and slide microtubules in the spindle.
Julie Cahu +8 more
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