Results 31 to 40 of about 3,876 (171)

Granule-Dependent NK Cell Killing of Cryptococcus Requires Kinesin to Reposition the Cytolytic Machinery for Directed Cytotoxicity

Cell Reports, 2018
Summary: Cryptococcus is the most important cause of fungal meningitis in immunocompromised individuals. Host defense against Cryptococcus involves direct killing by NK cells.
Henry Ogbomo, Martina Timm-McCann, Tavish Barnes, Richard F. Xiang, Khusraw Jamil, Anutosh Ganguly, Danuta Stack, Shaunna M. Huston, Shu Shun Li, Pina Colarusso, Christopher H. Mody   +10 more
doaj   +1 more source

New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy

, 2006
The treatment of malignant brain tumors poses a basic challenge in todays cancer therapy. Since the quantitative resection is hardly possible due to the invasive growth of the tumor, prevention of relapse after resection by concomitant irradiation ...
Gross, Dietmar
core   +1 more source

Kinesin Eg5 Targeting Inhibitors as a New Strategy for Gastric Adenocarcinoma Treatment

Molecules, 2019
The Kinesins are proteins involved in several biological processes such as mitosis, intracellular transport, and microtubule movement. The mitotic process is allowed by the correct formation of the mitotic spindle which consists of microtubules ...
Guya Diletta Marconi, Simone Carradori, Alessia Ricci, Paolo Guglielmi, Amelia Cataldi, Susi Zara   +5 more
doaj   +1 more source

Tetrazine-Induced Bioorthogonal Activation of Vitamin E-Modified siRNA for Gene Silencing

Molecules, 2022
The temporal activation of siRNA provides a valuable strategy for the regulation of siRNA activity and conditional gene silencing. The bioorthogonal bond-cleavage reaction of benzonorbonadiene and tetrazine is a promising trigger in siRNA temporal ...
Xueli Zhang, Amu Gubu, Jianfei Xu, Ning Yan, Wenbo Su, Di Feng, Qian Wang, Xinjing Tang   +7 more
doaj   +1 more source

Beyond Percolation: Graphene‐Enabled Network Reinforcement Enhances Thermal Transport in Paraffin Phase‐Change Composites

Advanced Science, EarlyView.
Expanded‐graphite/graphene‐nanoplatelet hybrids deliver a near‐order‐of‐magnitude thermal‐conductivity enhancement in paraffin phase‐change materials. A microCT‐informed 3D modeling framework resolves the percolating EG backbone and captures sub‐voxel GNP enrichment, quantitatively linking microstructure to heat flow and revealing a graphene‐enabled ...
Thomas Hoke, Jackson Hoke, Shucheng Guo, Brittany Chan, Xi Chen   +4 more
wiley   +1 more source

Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression

Advanced Science, EarlyView.
Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu, Yalin Liu, Rongyi Wang, Wenwen Xu, Hao Shi, Ning Huang, Junlin Teng, Jin Meng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

CDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following Mitosis. [PDF]

PLoS ONE, 2016
Cell proliferation is driven by cyclical activation of cyclin-dependent kinases (CDKs), which produce distinct biochemical cell cycle phases. Mitosis (M phase) is orchestrated by CDK-1, complexed with mitotic cyclins.
A Sophia Gayek, Ryoma Ohi
doaj   +1 more source

Integrated Machine Learning and Chemoinformatics-Based Screening of Mycotic Compounds against Kinesin Spindle ProteinEg5 for Lung Cancer Therapy

Molecules, 2022
Among the various types of cancer, lung cancer is the second most-diagnosed cancer worldwide. The kinesin spindle protein, Eg5, is a vital protein behind bipolar mitotic spindle establishment and maintenance during mitosis.
Priyanka Maiti, Priyanka Sharma, Mahesha Nand, Indra D. Bhatt, Muthannan Andavar Ramakrishnan, Shalini Mathpal, Tushar Joshi, Ragini Pant, Shafi Mahmud, Jesus Simal-Gandara, Sultan Alshehri, Mohammed M. Ghoneim, Maha Alruwaily, Ahmed Abdullah Al Awadh, Mohammed Merae Alshahrani, Subhash Chandra   +15 more
doaj   +1 more source

TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle [PDF]

, 2011
Mitotic spindle assembly requires the regulated activity of numerous spindle-associated proteins. In mammalian cells, the Kinesin-5 motor Eg5 interacts with the spindle assembly factor TPX2, but how this interaction contributes to spindle formation and ...
Janel Titus, Nan Ma, Alyssa Gable, Jennifer L. Ross, Patricia Wadsworth   +4 more
core   +1 more source

3D-QSAR Studies of Dihydropyrazole and Dihydropyrrole Derivatives as Inhibitors of Human Mitotic Kinesin Eg5 Based on Molecular Docking

Molecules, 2012
Human mitotic kinesin Eg5 plays an essential role in mitoses and is an interesting drug target against cancer. To find the correlation between Eg5 and its inhibitors, structure-based 3D-quantitative structure–activity relationship (QSAR) studies were ...
Wenjuan Yang, Zhihua Lin, Yuanqiang Wang, Jin Liu, Mao Shu, Xingyan Luo   +5 more
doaj   +1 more source