Results 51 to 60 of about 3,876 (171)
Kinesin molecular motor Eg5 functions during polypeptide synthesis
, 2011 The kinesin-related molecular motor Eg5 plays roles in cell division, promoting spindle assembly. We show that during interphase Eg5 is associated with ribosomes and is required for optimal nascent polypeptide synthesis. When Eg5 was inhibited, ribosomes
Jelena Jakovljevic +3 more
core +1 more source
The role of Eg5 in EML4-ALK driven lung cancer
, 2023 EML4-ALK fusions are found in approximately 5% of lung cancer patients. Multiple variants of the EML4-ALK fusion exist due to alternate breakpoints in the EML4 gene.
Sarah L. Pashley (17058616)
core +1 more source
Effectiveness of Nursing Program in Preparing Nurses for the Care of Patients with Epsilon Gamma5 [PDF]
Egyptian Journal of Health CareThe emergence of the EG5 variant, a sub-lineage of the Omicron variant, has posed significant challenges, placing nurses at the forefront of managing the outbreak through bedside care, hospital unit management, and contact tracing.
Zeinab Mohamed Ahmed +3 more
doaj +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, Volume 600, Issue 10, Page 1491-1518, May 2026.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
MECHANISM OF REGULATION OF KINESINS EG5 AND KIF15 BY TPX2
, 2018 Cell division is the fundamental process by which the replicated genetic material is faithfully segregated to form two identical daughter cells. The mitotic spindle is the macromolecular cytoskeletal structure that is built during every round of cell ...
Balchand, Sai Keshavan
core +1 more source
Interplay of RNA m6A/m1A/m5C/m7G/ψ Regulators Predicting the Prognosis of Pancreatic Cancer
FASEB BioAdvances, Volume 8, Issue 5, May 2026.In this study, we comprehensively analyze the 64 RNA modification regulators, including 24 m6A regulators, 13 m1A regulators, 12 m5C regulators, 9 m7G regulators, and 12 pseudouridine regulators in pancreatic cancer in TCGA, GTEx, and HPA databases. We investigate their RNA and protein expression, their association with patients' clinical significance,
Shiyin Chen +4 more
wiley +1 more source
Regulation of Eg5 and TPX2 During Mammalian Mitosis
, 2013 During mitosis, the microtubule cytoskeleton is completely rearranged to form a bipolar spindle that functions to congress and segregate a complete set of genetic material into two nascent daughter cells.
Titus, Janel
core +1 more source
Nature Communications, 2016 Eg5 has a role in spindle assembly and has been associated with tumorigenesis but it is not clear how its activity is regulated. Here, the authors show that the E3 ligase RNF20/40 regulates mitotic spindle assembly by regulating the stability of Eg5 ...
Yang Duan +15 more
doaj +1 more source
Generation cycles in experimental populations of a multivoltine insect
Journal of Animal Ecology, Volume 95, Issue 5, Page 782-794, May 2026.Although theory suggests various mechanisms by which environmental and ecological factors may drive generational fluctuations, our field‐cage experiment is the first to demonstrate how internal dynamics and external disturbances jointly produce synchronised, large‐scale outbreak cycles.
Takehiko Yamanaka +3 more
wiley +1 more source
Small-Molecule and Mutational Analysis of Allosteric Eg5 Inhibition by Monastrol [PDF]
, 2006 Background: A recent crystal structure of monastrol in a ternary complex with the kinesin Eg5 motor domain highlights a novel, induced-fit drug binding site at atomic resolution.
Mitchison, Timothy +3 more
core +1 more source