Results 41 to 50 of about 3,876 (171)

Projecting future damage costs of non‐native species using combined dynamical and cost–density equations

Ecological Applications, Volume 36, Issue 5, July 2026.
Abstract Biological invasions threaten biodiversity, economic stability, and public health, exacerbated by intensive global trade and transport. The economic costs of these invasions have exceeded US$2 trillion globally and continue to increase. Although past invasion costs have been described across various contexts, there are few robust projections ...
Danish A. Ahmed, Corey J. A. Bradshaw, Noor Tahat, Emma J. Hudgins, Pierre Courtois, Philip E. Hulme, Yuya Watari, Ali Serhan Tarkan, Ismael Soto, Phillip J. Haubrock, Paride Balzani, Ross N. Cuthbert   +11 more
wiley   +1 more source

Interaction of the mitotic inhibitor monastrol with human kinesin Eg5 [PDF]

, 2003
The microtubule-dependent kinesin-like protein Eg5 from Homo sapiens is involved in the assembly of the mitotic spindle. It shows a three-domain structure with an N-terminal motor domain, a central coiled coil, and a C-terminal tail domain. In vivo HsEg5
DeBonis, S, Gans, Pierre, Simorre, Jean-Pierre, Ebel, Christine, Cross, Robert, Hackney, DD, Lebeau, Luc, Cross, R, Hackney, David, Blangy, A, Gans, P, Wade, RH, Ebel, C, Wade, Richard,, Crevel, Isabelle, Debonis, Salvatore, Skoufias, DA, Blangy, Anne, Wade, Richard, H., Crevel, I, Kozielski, F, Skoufias, Dimitrios, Kozielski, Frank, Lebeau, L, Simorre, JP   +24 more
core   +1 more source

Kinesin Eg5 Selective Inhibition by Newly Synthesized Molecules as an Alternative Approach to Counteract Breast Cancer Progression: An In Vitro Study

Biology, 2022
Breast cancer (BC) is one of the most diagnosed cancers in women. Recently, a promising target for BC treatment was found in kinesin Eg5, a mitotic motor protein that allows bipolar spindle formation and cell replication.
Alessia Ricci, Amelia Cataldi, Simone Carradori, Susi Zara   +3 more
doaj   +1 more source

Making Two out of One: Kinesin Motors Driving Plant Cell Division

Cytoskeleton, Volume 83, Issue 6, Page 384-393, June 2026.
ABSTRACT The Kinesin superfamily of microtubule dependent motors is present in all eukaryotes. Not all of the subfamilies are represented in all kingdoms, and the ones that are do not always show conserved functions. Tight control of the cytoskeleton is essential for proper progression and completion of mitosis and cytokinesis, and key functions are ...
Choy Kriechbaum, Sabine Müller
wiley   +1 more source

Mechanisms of action of Eg5 inhibitors

, 2015
Many inhibitors have now been described that bind specifically to Eg5. It is clear that inhibition is allosteric and that the binding of inhibitors influences motor activity largely by influencing the dynamics of nucleotide exchange, but surprisingly ...
Robert A. Cross, Cross, R. A.
core   +1 more source

Planejamento in silico de cumarinas potencialmente inibidoras da cinesina Eg5 [PDF]

, 2023
O planejamento racional de compostos bioativos desempenha um papel crucial na descoberta de novos agentes terapêuticos. A cinesina Eg5, uma proteína essencial no processo de divisão celular, é um alvo promissor para intervenção farmacológica no ...
Ribeiro, Carolina Monteiro
core  

Molecular and Cell Biological Characterization of Patient‐Derived Head and Neck Squamous Carcinoma Cell Lines

Cancer Science, Volume 117, Issue 6, Page 1623-1634, June 2026.
Patient‐derived head and neck squamous cell carcinoma (HNSCC) cells were genomically and cytogenetically characterized, revealing actionable alterations and chromosomal instability. Targeted therapies suppressed growth according to EGFR amplification or PIK3CA mutation status.
Kazue Ito, Noriko Ishida, Shin Ito, Norihisa Shindo, Satoshi Souma, Mai Mochizuki, Haruna Fujimori, Keiichi Tamai, Takayuki Imai, Tomoko Yamazaki, Kazunori Yamaguchi, Kento Sasaki, Yuya Miyakura, Shigekazu Murakami, Yuka Unno, Naoki Asano, Yukinori Asada, Jun Yasuda   +17 more
wiley   +1 more source

Kinesin molecular motor Eg5 functions during polypeptide synthesis.

, 2018
The kinesin-related molecular motor Eg5 plays roles in cell division, promoting spindle assembly. We show that during interphase Eg5 is associated with ribosomes and is required for optimal nascent polypeptide synthesis. When Eg5 was inhibited, ribosomes
Kristen M. Bartoli (5065571), William S. Saunders (248453), Jelena Jakovljevic (3886744), John Woolford (3887968)   +3 more
core   +1 more source

NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization

Nature Communications, 2018
NEK7 is a kinase known for its role in mitotic spindle assembly, driving centrosome separation in prophase through regulation of the kinesin Eg5. Here, the authors show that NEK7 and Eg5 also control dendrite morphogenesis in postmitotic neurons.
Francisco Freixo, Paula Martinez Delgado, Yasmina Manso, Carlos Sánchez-Huertas, Cristina Lacasa, Eduardo Soriano, Joan Roig, Jens Lüders   +7 more
doaj   +1 more source

The Long Haul: Microtubule Motors as the Essential Supply Line for Neuronal Longevity

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
To survive a lifetime, neurons depend on a high‐fidelity logistics network powered by microtubule motors. We explore how a broad spectrum of genetic defects in this machinery drive a devastating spectrum of neurodevelopmental and neurodegenerative diseases, including Hereditary Spastic Paraplegia (HSP), Charcot–Marie‐Tooth Type 2 (CMT2), and ...
Emma D. Turner, Alison E. Twelvetrees
wiley   +1 more source